4-Fluoro-2(3H)-Benzothiazolethione
- CAS No.
- 154327-24-9
- Chemical Name:
- 4-Fluoro-2(3H)-Benzothiazolethione
- Synonyms
- 2-mercapto-4-fluorobenzothiazole;4-Fluorobenzo[d]thiazole-2-thiol;4-Fluoro-2-mercaptobenzothiazole;4-Fluoro-2(3H)-Benzothiazolethione;4-Fluoro-1,3-benzothiazole-2-thiol;2(3H)-Benzothiazolethione, 4-fluoro-;4-Fluorobenzo[d]thiazole-2(3H)-thione;4-Fluorobenzo[d]thiazole-2-thiol
- CBNumber:
- CB02484604
- Molecular Formula:
- C7H4FNS2
- Molecular Weight:
- 185.24
- MDL Number:
- MFCD06408877
- MOL File:
- 154327-24-9.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| HS Code | 2934208090 |
4-Fluoro-2(3H)-Benzothiazolethione price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | F597003 | 4-Fluoro-2-mercaptobenzothiazole | 154327-24-9 | 25mg | $45 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0366324 | 4-FLUOROBENZO[D]THIAZOLE-2(3H)-THIONE 95.00% | 154327-24-9 | 1G | $257.25 | 2021-12-16 | Buy |
| Apolloscientific | PC902198 | 4-Fluoro-2-mercaptobenzothiazole 98% | 154327-24-9 | 5g | $646 | 2021-12-16 | Buy |
| Crysdot | CD11248323 | 4-Fluorobenzo[d]thiazole-2(3H)-thione 95+% | 154327-24-9 | 1g | $49 | 2021-12-16 | Buy |
| Absolute Chiral | O1067-00-N | 4-fluorobenzo[d]thiazole-2-thiol 95% | 154327-24-9 | 100mg | $108 | 2021-12-16 | Buy |
4-Fluoro-2(3H)-Benzothiazolethione Chemical Properties,Uses,Production
Synthesis
5509-65-9
140-89-6
154327-24-9
General method: GP3-1: 2,6-Difluoroaniline (1.0 eq.) was dissolved with potassium ethylxanthate (1.2 eq. or 2.2 eq., usually 2.2 eq. was used) in 10 volumes of anhydrous DMF and heated under nitrogen protection for 4 hrs. at 100°C or 120°C. The reaction progress was monitored by TLC. Upon completion of the reaction, the mixture was cooled to room temperature, diluted with 10 volumes of water and neutralized with 1 M HCl solution to pH 5. The resulting precipitate was collected by filtration, washed with water, dried by rotary evaporator and then further dried in an oil pump.GP3-2: Thionyl chloride (SO2Cl2, 1 volume) was slowly added to 10 volumes of anhydrous DMF containing 2-mercaptobenzothiazole (obtained in step GP3-1) under the cooling conditions of an ice bath. step) in 10 volumes of anhydrous DCM solution. The reaction mixture was stirred at room temperature for 1 h. The reaction progress was monitored by TLC. After complete consumption of raw materials, the reaction mixture was diluted with 30 volumes of ether and the reaction was quenched by careful addition of water. Stirring was continued for 1 hour to ensure complete consumption of SO2Cl2 and release of the product. The organic layer was separated, neutralized with saturated NaHCO3 solution, dried over Na2SO4 and finally purified by silica gel column chromatography to afford the pure 2-mercapto-4-fluorobenzothiazole. The structure of the product was confirmed by LC-MS and NMR.
References
[1] Synthetic Communications, 2007, vol. 37, # 3, p. 369 - 376
[2] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 24, p. 7661 - 7670
[3] Advanced Synthesis and Catalysis, 2017, vol. 359, # 11, p. 1837 - 1843
[4] Journal of the American Chemical Society, 2013, vol. 135, # 41, p. 15579 - 15584
4-Fluoro-2(3H)-Benzothiazolethione Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | 52513593@qq.com | CHINA | 2972 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29800 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| CR Corporation Limited | +8613062833949 | fred.wen@crcorporation.cn | China | 8647 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33338 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Energy Chemical | 021-021-58432009 400-005-6266 | sales8178@energy-chemical.com | China | 44733 | 61 |
View Lastest Price from 4-Fluoro-2(3H)-Benzothiazolethione manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![4-Fluorobenzo[d]thiazole-2(3H)-thione pictures](/ProductImageEN/2022-01/Small/5a698ecf-6ff8-42bd-95e1-77328afef11a.jpeg) |
2022-01-15 | 4-Fluorobenzo[d]thiazole-2(3H)-thione
154327-24-9
|
US $0.00 / KG | 1KG | 97.7% | 100 tons | Honest Joy Holdings Limited | |
 |
2020-01-14 | 4-Fluoro-2(3H)-Benzothiazolethione
154327-24-9
|
US $9.80 / KG | 1g | ≥99% | 100kg | Career Henan Chemical Co |
-
- 4-Fluorobenzo[d]thiazole-2(3H)-thione
154327-24-9
- US $0.00 / KG
- 97.7%
- Honest Joy Holdings Limited
-
- 4-Fluoro-2(3H)-Benzothiazolethione
154327-24-9
- US $9.80 / KG
- ≥99%
- Career Henan Chemical Co
