Amuvatinib
- CAS No.
- 850879-09-3
- Chemical Name:
- Amuvatinib
- Synonyms
- AMuvatinib;Mp470;HPK 56;CS-460;MP470;HPK 56;MP-470(MP 470);AMuvatinib (MP-470);MP-470 (Amuvatinib);MP470 AMUVATINIB (MP-470);Amuvatinib, 10 mM in DMSO
- CBNumber:
- CB02484967
- Molecular Formula:
- C23H21N5O3S
- Molecular Weight:
- 447.51
- MDL Number:
- MFCD16038298
- MOL File:
- 850879-09-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Amuvatinib ≥98% | 21461 | 1mg | $121 |
| Amuvatinib ≥98% | 21461 | 5mg | $240 |
| Amuvatinib ≥98% | 21461 | 10mg | $418 |
| Amuvatinib ≥98% | 21461 | 25mg | $894 |
| Amuvatinib ≥98% | 21461 | 1mg | $110 |
| More product size | |||
| Density | 1.443 |
|---|---|
| storage temp. | Store at -20°C |
| solubility | ≥22.4 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
| form | solid |
| color | White to off-white |
| CAS DataBase Reference | 850879-09-3 |
| NCI Dictionary of Cancer Terms | amuvatinib; MP470 |
| FDA UNII | SO9S6QZB4R |
| NCI Drug Dictionary | amuvatinib |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
Amuvatinib price More Price(76)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21461 | Amuvatinib ≥98% | 850879-09-3 | 1mg | $121 | 2026-04-30 | Buy |
| Cayman Chemical | 21461 | Amuvatinib ≥98% | 850879-09-3 | 5mg | $240 | 2026-04-30 | Buy |
| Cayman Chemical | 21461 | Amuvatinib ≥98% | 850879-09-3 | 10mg | $418 | 2026-04-30 | Buy |
| Cayman Chemical | 21461 | Amuvatinib ≥98% | 850879-09-3 | 25mg | $894 | 2026-04-30 | Buy |
| Cayman Chemical | 21461 | Amuvatinib ≥98% | 850879-09-3 | 1mg | $110 | 2024-03-01 | Buy |
Amuvatinib Chemical Properties,Uses,Production
Description
Amuvatinib (also known as MP-470 or 850879-09-3), is a multi-targeted inhibitor of receptor tyrosine kinases that inhibits c-Kit, platelet-derived growth factor receptor α (PDGFRα), and c-Met (IC50s = 10, 40, and 81 nM, respectively). It inhibits growth and induces apoptosis in prostate cancer cell lines, with additive effects achieved when combined with erlotinib . Amuvatinib sensitizes cancer cells to radiation and chemotherapeutic compounds, in part by inhibiting homologous recombination.
Uses
MP-470 (Amuvatinib) is a potent and multi-targeted inhibitor of c-KitD816H, PDGFαV561D and Flt3D835Y with IC50 of 10 nM, 40 nM and 81 nM, respectively.
Definition
ChEBI: N-(1,3-benzodioxol-5-ylmethyl)-4-(4-benzofuro[3,2-d]pyrimidinyl)-1-piperazinecarbothioamide is a N-arylpiperazine.
Clinical Use
Amivantamab is the first drug approved by the FDA for the treatment of patients with NSCLC and EGFR exon 20 insertion mutations.
Synthesis
![4-(piperazin-1-yl)benzofuro[3,2-d]pyrimidine](/CAS/20180703/GIF/380339-27-5.gif)
380339-27-5
1015482-56-0
850879-09-3
Example 21: 4-(Benzo[4,5]furo[3,2-d]pyrimidin-4-yl)piperazine-1-carbothioic acid (200 mg, 0.79 mmol) and pyridine (0.5 mL, 7.9 mmol) were dissolved in dichloromethane (20 mL), and N-(benzo[d][1,3]dioxol-5- ylmethyl)carbamoyl chloride was added slowly with stirring to a dichloromethane solution (20 mL). The reaction mixture was stirred overnight at room temperature. Upon completion of the reaction, methanol was added to quench the excess sulfur phosgene. The solvent was removed by concentration under reduced pressure and the residue was purified by silica gel column chromatography using 5% methanol/dichloromethane as eluent. The target fraction was collected and concentrated to give the crude product, which was further purified by recrystallization from dichloromethane/hexane to give a white solid product (150 mg, 37% yield). The structure of the product was confirmed by 1H NMR (CDCl3, 300 MHz) and FAB HRMS as expected. The results of elemental analysis were consistent with theoretical values.
target
c-KitD816H
Mode of action
Μechanisticly, amuvatinib inhibits tyrosine kinase receptor KIT through occupying its ATP binding domain (IC50 < 0.1 μM) and disrupts DNA repair through suppression of homologous recombination protein Rad51 as well as synergistic effects in combination with double stranded DNA damaging agents.
References
1. Effects of combining amuvatinib (MP-470) with DNA-damaging agents in osteosarcoma cell lines
2. Janssen submits supplemental biologics license application to the U.S. Food and Drug Administration seeking approval of RYBREVANT (amivantamab-vmjw) in combination with chemotherapy for the first-line treatment of patients with locally advanced or metastatic EGFR exon 20 insertion mutation-positive non-small cell lung cancer. News release.
3. Raoul Tibes, Gil Fine, Gavin Choy, Sanjeev Redkar, Pietro Taverna, Aram Oganesian, Amarpao Sahai, Mohammad Azab and Anthony W. Tolcher. A phase I, first-in-human dose-escalation study of amuvatinib, a multi-targeted tyrosine kinase inhibitor, in patients with advanced solid tumors. Cancer Chemother Pharmacol (2013) 71: 463-471
4. Gavin Choy, Rajashree Joshi-Hangal, Aram Oganesian, Gil Fine, Scott Rasmussen, Joanne Collier, James Kissling, Amarpal Sahai, Mohammad Azab and Sanjeev Redkar. Saftety, tolerability, and pharmacokinetics of amuvatinib from three phase 1 clinical studies in healthy volunteers. Cancer Chemother Pharmacol (2012) 70: 183-190
Amuvatinib Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 19827 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| changzhou huayang technology co., ltd | +8615250961469 | 2571773637@qq.com | China | 9653 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
View Lastest Price from Amuvatinib manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | Amuvatinib
850879-09-3
|
$44.00-93.00 | 99.94% | 10g | TargetMol Chemicals Inc. | ||
![N-(1,3-Benzodioxol-5-ylmethyl)-4-benzofuro[3,2-d]pyrimidin-4-yl-1-piperazinecarbothioamide pictures](https://img.chemicalbook.com/ProductImageEN/2018-8/Small/bbdb9265-b39c-4192-8b4c-075309dee9d7.gif) |
2019-07-06 | N-(1,3-Benzodioxol-5-ylmethyl)-4-benzofuro[3,2-d]pyrimidin-4-yl-1-piperazinecarbothioamide
850879-09-3
|
$500.00 | 1KG | 98% | 100kg | Career Henan Chemical Co |
-
- Amuvatinib
850879-09-3
- $44.00-93.00
- 99.94%
- TargetMol Chemicals Inc.
-
- N-(1,3-Benzodioxol-5-ylmethyl)-4-benzofuro[3,2-d]pyrimidin-4-yl-1-piperazinecarbothioamide
850879-09-3
- $500.00
- 98%
- Career Henan Chemical Co
