3-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoicacid
- CAS No.
- 1092400-82-2
- Chemical Name:
- 3-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoicacid
- Synonyms
- 3-(5-(Trifluoromethyl);-1,2,4-oxadiazol-3-yl);thiophene-2,5-diyldiMethanol;3-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoicacid;Benzoic acid, 3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]-
- CBNumber:
- CB02489654
- Molecular Formula:
- C10H5F3N2O3
- Molecular Weight:
- 258.15
- MDL Number:
- MFCD09907879
- MOL File:
- 1092400-82-2.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| HS Code | 2916399090 |
3-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoicacid price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC210001 | 3-[5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzoic acid 98% | 1092400-82-2 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC210001 | 3-[5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzoic acid 98% | 1092400-82-2 | 1g | $43 | 2026-06-04 | Buy |
| Apolloscientific | PC210001 | 3-[5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzoic acid 98% | 1092400-82-2 | 5g | $204 | 2026-06-04 | Buy |
| Apolloscientific | PC210001 | 3-[5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzoic acid 98% | 1092400-82-2 | 25g | $950 | 2026-06-04 | Buy |
| Matrix Scientific | 115212 | 3-[5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzoic acid | 1092400-82-2 | 500.00mg | $808 | 2026-05-18 | Buy |
3-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoicacid Chemical Properties,Uses,Production
Synthesis
![3-[(HYDROXYAMINO)IMINOMETHYL]-BENZOIC ACID](/CAS/GIF/199447-10-4.gif)
199447-10-4
407-25-0
1092400-82-2
3-(N-hydroxyformamidinyl)benzoic acid (1 g, 5.6 mmol) was dissolved in anhydrous pyridine (15 mL) and cooled to 0 °C. Trifluoroacetic anhydride (2.3 mL, 16.7 mmol) was added slowly and dropwise. After the reaction mixture was gradually warmed to room temperature, it was further heated to 50 °C and the reaction was maintained for 3 hours. After completion of the reaction, the mixture was poured into ice water and the pH was adjusted to 4 with 1.5 N HCl. The product was extracted with EtOAc and concentrated under reduced pressure to remove the solvent. The crude product was purified by column chromatography (silica gel 60-120 mesh, eluent: 10% EtOAc/petroleum ether) to afford the target compound 3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid (400 mg, 28% yield). The product was confirmed by 1H NMR (400 MHz, CDCl3): δ 13.44 (br s, 1H), 8.56 (s, 1H), 8.30 (d, J=7.9 Hz, 1H), 8.21 (d, J=7.9 Hz, 1H), 7.78 (t, J=7.8 Hz, 1H). Mass spectrometry (ESI) analysis: m/z calculated value of C10H5F3N2O3 was 258.03; measured value 257 (M-H).
References
[1] Patent: WO2013/6408, 2013, A1. Location in patent: Page/Page column 39; 40
[2] Patent: EP2533783, 2015, B1. Location in patent: Paragraph 0136-0137
[3] Patent: WO2017/112838, 2017, A1. Location in patent: Paragraph 87
3-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoicacid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| EnciPharmatech Co., Ltd | 025-52714267-66 13813902930 | stephen_shengll@hotmail.com | China | 231 | 64 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9336 | 55 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| Cochemical Ltd. | 029-86115547 17791676824 | sales@cochemical.com | China | 3014 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| DKMbiochem.Co. Ltd | 15901859516 | sales@DKMbiochem.com | China | 361 | 58 |
| Shanghai YuLue Chemical Co., Ltd. | 021-60345187 13671753212 | lzz841106@aliyun.com | China | 10244 | 55 |
View Lastest Price from 3-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoicacid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 3-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoicacid
1092400-82-2
|
$1.00 | 1KG | 99% | 20kg | Career Henan Chemical Co |
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- 3-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoicacid
1092400-82-2
- $1.00
- 99%
- Career Henan Chemical Co
