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4H-Pyrrolo [1,2-B] pyrazole -2-carboxylic acid , 5,6-dihydro -, Potassium Salt

4H-Pyrrolo [1,2-B] pyrazole -2-carboxylic acid , 5,6-dihydro -, Potassium Salt structure

CAS No.: 86477-09-0

Chemical Name:: 4H-Pyrrolo [1,2-B] pyrazole -2-carboxylic acid , 5,6-dihydro -, Potassium Salt

Synonyms: Ethyl 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylate;5,6-dihydro-4H-Pyrrolo[1,2-b]pyrazole-2-carboxylic acid ethyl ester;4H-Pyrrolo[1,2-b]pyrazole-2-carboxylic acid, 5,6-dihydro-, ethyl ester;4H-Pyrrolo [1,2-B] pyrazole -2-carboxylic acid , 5,6-dihydro -, Potassium Salt;4H-Pyrrolo [1,2-B] pyrazole -2-carboxylic acid , 5,6-dihydro -, Potassium Salt (1:1)

CBNumber:: CB02510280

Molecular Formula:: C9H12N2O2

Molecular Weight:: 180.2

MDL Number:: MFCD11975789

MOL File:: 86477-09-0.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:47

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4H-Pyrrolo [1,2-B] pyrazole -2-carboxylic acid , 5,6-dihydro -, Potassium Salt Properties

Melting point	61-63 °C
Boiling point	320.0±30.0 °C(Predicted)
Density	1.29±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
pka	0.56±0.20(Predicted)
Appearance	Light yellow to yellow Solid
InChI	InChI=1S/C9H12N2O2/c1-2-13-9(12)8-6-7-4-3-5-11(7)10-8/h6H,2-5H2,1H3
InChIKey	MGGGSJRWNQFCLE-UHFFFAOYSA-N
SMILES	N1=C(C(OCC)=O)C=C2CCCN12

SAFETY

Risk and Safety Statements

HS Code	2933998090

4H-Pyrrolo [1,2-B] pyrazole -2-carboxylic acid , 5,6-dihydro -, Potassium Salt price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Apolloscientific	OR930225	Ethyl 5,6-dihydro-4h-pyrrolo[1,2-b]pyrazole-2-carboxylate >99%	86477-09-0	100mg	$21	2026-06-04	Buy
Apolloscientific	OR930225	Ethyl 5,6-dihydro-4h-pyrrolo[1,2-b]pyrazole-2-carboxylate >99%	86477-09-0	250mg	$22	2026-06-04	Buy
Apolloscientific	OR930225	Ethyl 5,6-dihydro-4h-pyrrolo[1,2-b]pyrazole-2-carboxylate >99%	86477-09-0	1g	$82	2026-06-04	Buy
Apolloscientific	OR930225	Ethyl 5,6-dihydro-4h-pyrrolo[1,2-b]pyrazole-2-carboxylate >99%	86477-09-0	5g	$168	2026-06-04	Buy
Apolloscientific	OR930225	Ethyl 5,6-dihydro-4h-pyrrolo[1,2-b]pyrazole-2-carboxylate >99%	86477-09-0	25g	$697	2026-06-04	Buy

Product number	Packaging	Price	Buy
OR930225	100mg	$21	Buy
OR930225	250mg	$22	Buy
OR930225	1g	$82	Buy
OR930225	5g	$168	Buy
OR930225	25g	$697	Buy

4H-Pyrrolo [1,2-B] pyrazole -2-carboxylic acid , 5,6-dihydro -, Potassium Salt Chemical Properties, Uses, Production

Synthesis

3a,4,5,6-tetrahydro-3-oxo-3H-Pyrrolo[1,2-c][1,2,3]oxadiazol-7-
iuM inner salt

98262-66-9

623-47-2

4H-Pyrrolo [1,2-C][1,2,3] oxadiazol -7-ium, 5,6-Dihydro -3-Hydroxy -, inner Salt

86477-10-3

4H-Pyrrolo [1,2-B] pyrazole -2-carboxylic acid , 5,6-dihydro -, Potassium Salt

86477-09-0

A reaction was carried out with 3a,4,5,6-tetrahydro-3-oxo-3H-pyrrolo[1,2-c][1,2,3]oxadiazol-7-ium innerium salt (13.5 g, 0.107 mol, crude from Example 4) and ethyl propargylate (15.8 g, 16.3 ml, 0.16 mol) in anhydrous N,N-dimethylformamide (50 ml) under nitrogen The reaction was stirred under protection and heated to 120-122 °C for 12 hours. The course of the reaction was monitored by HPLC (using a Prodigy ODS3 4.6×150 mm column with 90:10 to 10:90 water/acetonitrile containing 0.02% trifluoroacetic acid as the mobile phase in a gradient elution for 10 min). Under these conditions, the retention time of ethyl 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylate (the more polar target isomer) was 2.6-2.7 min, whereas the retention time of ethyl 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-3-carboxylate (the less polar non-target isomer) was 2.8-2.9 min. The UV detector was set at 215 nm because the absorption difference between the two isomers is significant at 254 nm and the non-target isomer is almost undetectable. After completion of the reaction, the mixture was concentrated to a dark syrupy consistency using an oil pump vacuum at a bath temperature not exceeding 50 °C. The ratio of the two esters in the dark syrup was 2.13:1 in favor of the target product ethyl 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylate as determined by NMR. The dark syrup was diluted with toluene and up-sampled by washing with hexane to a silica gel column (500 mL) preloaded in hexane. The column was eluted first with hexane-ethyl acetate (4:1) followed by hexane-ethyl acetate (1:1). The elution process was monitored by HPLC (conditions as above). Fractions containing both esters were collected and separated again by column chromatography. Fractions containing only ethyl 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylate were combined and concentrated to give 11 g (57%) of the pure product in white crystalline form with a melting point of 35-37 °C. Similarly, 6.5 g (33.7%) of ethyl 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-3-carboxylate was obtained as white crystals with a melting point of 205 °C.

References

[1] Patent: US2004/242874, 2004, A1. Location in patent: Page 13-14
[2] Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1991, vol. 30, # 2, p. 169 - 175
[3] Patent: US2004/242874, 2004, A1. Location in patent: Page 12-13
[4] Patent: US2004/242874, 2004, A1. Location in patent: Page 13
[5] Organic Process Research and Development, 2006, vol. 10, # 4, p. 712 - 716

4H-Pyrrolo [1,2-B] pyrazole -2-carboxylic acid , 5,6-dihydro -, Potassium Salt Preparation Products And Raw materials

Raw materials

3a,4,5,6-tetrahydro-3-oxo-3H-Pyrrolo[1,2-c][1,2,3]oxadiazol-7- iuM inner salt Ethyl propiolate

Preparation Products

4H-Pyrrolo [1,2-B] pyrazole -2-carboxylic acid , 5,6-dihydro -, Potassium Salt Suppliers

Global Suppliers ( 44)

Supplier	Tel	Email	Country	ProdList	Advantage
wuhan Dekray Biomedical Technology Co.,Ltd	027-69573188 18221423799	1503407886@qq.com	China	1766	58
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Shanghai yirong biology science and technology co., ltd	18049974220	3060526242@qq.com	China	999	60
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.	+86-28-85122536 85324413	market@astatech.cn	China	8016	55
Jiaxing Novartis Chemical Co., Ltd.	18957373295		China	1579	58
ShangHai Yuchuan Pharmaceutical Technology Co., Ltd.	02161555100		China	820	58
Chengdu Xiaojia Technology Co., Ltd.	15902830537	zhanghao@happysyn.com	China	2359	55
NanJing Xienuo bio Co.,Ltd.	025-84112752 13805181430	154301870@qq.com	China	999	55
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131885	58
Nanjing KaiMubo Pharmaceutical Co., Ltd.	025-66162170		China	7180	55

Supplier	Advantage
wuhan Dekray Biomedical Technology Co.,Ltd	58
Pure Chemistry Scientific Inc.	62
Shanghai yirong biology science and technology co., ltd	60
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.	55
Jiaxing Novartis Chemical Co., Ltd.	58
ShangHai Yuchuan Pharmaceutical Technology Co., Ltd.	58
Chengdu Xiaojia Technology Co., Ltd.	55
NanJing Xienuo bio Co.,Ltd.	55
Amadis Chemical Company Limited	58
Nanjing KaiMubo Pharmaceutical Co., Ltd.	55

4H-Pyrrolo [1,2-B] pyrazole -2-carboxylic acid , 5,6-dihydro -, Potassium Salt Spectrum

4H-Pyrrolo [1,2-B] pyrazole -2-carboxylic acid , 5,6-dihydro -, Potassium Salt(86477-09-0)¹HNMR

86477-09-0 (4H-Pyrrolo [1,2-B] pyrazole -2-carboxylic acid , 5,6-dihydro -, Potassium Salt) Related Search:

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4H-Pyrrolo [1,2-B] pyrazole -2-carboxylic acid , 5,6-dihydro -, Potassium Salt (1:1) 5,6-dihydro-4H-Pyrrolo[1,2-b]pyrazole-2-carboxylic acid ethyl ester Ethyl 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylate 4H-Pyrrolo [1,2-B] pyrazole -2-carboxylic acid , 5,6-dihydro -, Potassium Salt 4H-Pyrrolo[1,2-b]pyrazole-2-carboxylic acid, 5,6-dihydro-, ethyl ester 86477-09-0