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2'-O-(2-Methoxyethyl)guanosine

2'-O-(2-Methoxyethyl)guanosine structure

CAS No.: 473278-54-5

Chemical Name:: 2'-O-(2-Methoxyethyl)guanosine

Synonyms: 2-amino-9-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)-1,9-dihydro-6H-purin-6-one;2'-MOE-G;2'-MOE-rG;2'-O-MOE-G;2'-O-MOE-Gr;2'-O-MOE-rG;2'-MOE-Guanosine;2'-O-MOE Guanosine;2'-O-Methoxyethylguanosine;2'-O-Methoxyethyl-guanosine

CBNumber:: CB02510482

Molecular Formula:: C13H19N5O6

Molecular Weight:: 341.32

MDL Number:: MFCD02682962

MOL File:: 473278-54-5.mol

Last updated:2025-08-21 14:05:29

Product description	Number	Pack Size	Price
2''-O-(2-Methoxyethyl)guanosine	M262525	10mg	$165
2''-O-(2-Methoxyethyl)guanosine	M262525	100mg	$1320
2'-O-(2-Methoxyethyl)guanosine	NM57537	5G	$625
2'-O-(2-Methoxyethyl)guanosine	NM57537	1g	$200
2'-O-(2-Methoxyethyl)guanosine	NM57537	2g	$300
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2'-O-(2-Methoxyethyl)guanosine Properties

Boiling point	715.0±70.0 °C(Predicted)
Density	1.81±0.1 g/cm3(Predicted)
storage temp.	2-8°C(protect from light)
solubility	Acetonitrile: Slightly Soluble: 0.1-1 mg/ml DMSO: Sparingly Soluble: 1-10 mg/ml Water: Slightly Soluble: 0.1-1 mg/ml
form	Solid
pka	13.20±0.70(Predicted)
color	White to off-white
InChI	InChI=1S/C13H19N5O6/c1-22-2-3-23-9-8(20)6(4-19)24-12(9)18-5-15-7-10(18)16-13(14)17-11(7)21/h5-6,8-9,12,19-20H,2-4H2,1H3,(H3,14,16,17,21)/t6-,8-,9-,12-/m1/s1
InChIKey	DLLBJSLIKOKFHE-WOUKDFQISA-N
SMILES	OC[C@H]1O[C@@H](N2C3=C(C(NC(=N3)N)=O)N=C2)[C@H](OCCOC)[C@@H]1O
FDA UNII	509W6DE18G

2'-O-(2-Methoxyethyl)guanosine price More Price(12)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	M262525	2''-O-(2-Methoxyethyl)guanosine	473278-54-5	10mg	$165	2021-12-16	Buy
TRC	M262525	2''-O-(2-Methoxyethyl)guanosine	473278-54-5	100mg	$1320	2021-12-16	Buy
Biosynth Carbosynth	NM57537	2'-O-(2-Methoxyethyl)guanosine	473278-54-5	5G	$625	2021-12-16	Buy
Biosynth Carbosynth	NM57537	2'-O-(2-Methoxyethyl)guanosine	473278-54-5	1g	$200	2021-12-16	Buy
Biosynth Carbosynth	NM57537	2'-O-(2-Methoxyethyl)guanosine	473278-54-5	2g	$300	2021-12-16	Buy

Product number	Packaging	Price	Buy
M262525	10mg	$165	Buy
M262525	100mg	$1320	Buy
NM57537	5G	$625	Buy
NM57537	1g	$200	Buy
NM57537	2g	$300	Buy

2'-O-(2-Methoxyethyl)guanosine Chemical Properties,Uses,Production

Description

2'-O-(2-Methoxyethyl)-guanosine is a guanosine derivative isolated from the reaction of 2-aminoadenosine with methylsulfonyl chloride. 2'-O-(2-Methoxyethyl)-guanosine can be used as a building block for cross-linking oligonucleotides.

Uses

A guanosine derivative as building blocks for cross-linking oligonucleotides.

Definition

2'-O-(2-Methoxyethyl)guanosine, a 2′-O-methoxyethyl-modified nucleoside, can be produced by enzymatic conversion (adenosine deaminase) from 2′-O-(2-methoxyethyl)-2,6-diaminopurine riboside.

Synthesis

Guanosine, 2'-O-(2-methoxyethyl)-3',5'-O-[methylenebis[bis(1-methylethyl)silylene]]- (9CI)

473278-53-4

473278-54-5

Compound 7 (50 mg, 0.086 mmol) was used as a starting material, which was dissolved in a mixed solvent of THF and water, and TBAF (1 M solution of THF, 0.009 mL, 0.009 mmol) was added at 25 °C. The reaction mixture was warmed up to 35 °C with continuous stirring for 5 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was purified by filtration through a short silica gel column using a dichloromethane solution of 10% methanol as eluent to afford the target product 2'-O-MOE G (compound 8) (28 mg, 0.082 mmol, 97% yield). The 1H NMR (400 MHz, DMSO) data of compound 8 were as follows: δ 10.68 (s, 1H), 7.95 (s, 1H), 6.50 (s, 2H), 5.78 (d, J = 6.0 Hz, 1H), 5.08 (d, J = 5.2 Hz, 2H), 4.33 (d, J = 6.0 Hz, 1H), 4.23 (d, J = 3.2 Hz, 1H), 3.88 (d, J = 3.2 Hz, 1H), 3.65 (m, 3H), 3.52-3.57 (m, 2H), 3.35 (s, 3H), 3.38-3.40 (m, 1H).

References

[1] Nucleosides, nucleotides and nucleic acids, 2003, vol. 22, # 5-8, p. 583 - 587
[2] The Journal of organic chemistry, 2002, vol. 67, # 22, p. 7887 - 7889
[3] Patent: US2003/225262, 2003, A1. Location in patent: Page column 34-35
[4] AMER F SALEH. 2’-O-(2-Methoxyethyl) Nucleosides Are Not Phosphorylated or Incorporated Into the Genome of Human Lymphoblastoid TK6 Cells.[J]. Toxicological Sciences, 2018: 70-78. DOI: 10.1093/toxsci/kfy005

2'-O-(2-Methoxyethyl)guanosine Preparation Products And Raw materials

Raw materials

Guanosine, 2'-O-(2-methoxyethyl)-3',5'-O-[methylenebis[bis(1-methylethyl)silylene]]- (9CI) Water Tetrabutylammonium fluoride Tetrahydrofuran

Preparation Products

N2-iso-Butyroyl-2'-O-(2-methoxyethyl)guanosine

2'-O-(2-Methoxyethyl)guanosine Suppliers

Global( 151)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29833	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10405	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Yunbio Tech Co.,Ltd.	+86-010-60605551 +86-18046518538	yunbiochem@126.com	China	321	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9636	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5742	58
Finetech Industry Limited	+86-27-8746-5837 +8619945049750	info@finetechnology-ind.com	China	9629	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52846	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Jinan Carbotang Biotech Co.,Ltd.	58
Yunbio Tech Co.,Ltd.	58
BOC Sciences	58
Antai Fine Chemical Technology Co.,Limited	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
Finetech Industry Limited	58
Dayang Chem (Hangzhou) Co.,Ltd.	58

View Lastest Price from 2'-O-(2-Methoxyethyl)guanosine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-04-04	2'-O-(2-Methoxyethyl)guanosine 473278-54-5	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2024-08-07	2'-O-(2-Methoxyethyl)guanosine 473278-54-5	US $0.00-0.00 / KG	1KG	99%	200KG per month	Yunbio Tech Co.,Ltd.
2023-04-04	2'-O-(2-Methoxyethyl)guanosine 473278-54-5	US $0.00-0.00 / kg	1kg	98%	500kg per month	Zhejiang Hengkang Pharmaceutical Co., Ltd.

2'-O-(2-Methoxyethyl)guanosine
473278-54-5
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

2'-O-(2-Methoxyethyl)guanosine
473278-54-5
US $0.00-0.00 / KG
99%
Yunbio Tech Co.,Ltd.

2'-O-(2-Methoxyethyl)guanosine
473278-54-5
US $0.00-0.00 / kg
98%
Zhejiang Hengkang Pharmaceutical Co., Ltd.

2'-O-(2-Methoxyethyl)guanosine Spectrum

2'-O-(2-Methoxyethyl)guanosine(473278-54-5)¹HNMR

473278-54-5(2'-O-(2-Methoxyethyl)guanosine)Related Search:

Ethylhexyl Triazone 2'-O-Methylcytidine DMT-2μ-O-Me-rG(ib) amidite 2’-O-Methyl-rA(N-Bz)phosphoramidite DMT-2′Fluoro-dU Phosphoramidite

2'-O-MOE-A(Bz)-3'-phosphoramidite 2'-O-(2-Methoxyethyl)-5-methyluridine N-blocked-5'-O-DMT-2'-O-Me CED cytosine phosphoramidite N4-Benzoyl-5'-O-DMT-2'-O-methyl-5-methylcytidine 3'-CE phosphoramidite Dmt-2'-f-dc(ac) amidite

2'-O-Methyladenosine 2'-O-(2-Methoxyethyl)cytidine 2'-O-Methylguanosine 2'-O-(2-Methoxyethyl)uridine DMT-2'-O-MOE-rU Phosphoramidite

2'-O-MOE-ADENOSINE 2'-OMe-ibu-G Phosphoramidite

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Guanosine, 2'-O-(2-Methoxyethyl)- 2'-O-(2-Methoxyethyl)guanosine 2-amino-9-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)-1,9-dihydro-6H-purin-6-one 2'-MOE-rG 2'-O-(2-Methoxyethyl)-guanosine, >97% 2'-O-MOE-Gr 2'-O-Methoxyethyl-guanosine 2'-O-MOE-rG 2-Amino-9-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)-3H-purin-6(9H)-one 2'-MOE-Guanosine 2'-O-(2-Methoxyethyl)guanosine 2'-MOE-rG 2'-MOE-G 2'-O-MOE Guanosine 2'-O-Methoxyethylguanosine 2'-O-MOE-G 2 ' - 0 - (2 -Methoxyethyl)guanosine 2-AMINO-9-[4-HYDROXY-5-(HYDROXYMETHYL)-3-(2-METHOXYETHOXY)OXOLAN-2-YL]-3H-PURIN-6-ONE 473278-54-5 Bases & Related Reagents Carbohydrates & Derivatives Heterocycles Nucleotides Modified（deoxy）nucleoside Nucleosides-2'-O-MOE Nucleosides