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N-Ethyl-p-menthane-3-carboxamide

N-Ethyl-p-menthane-3-carboxamide Structure
N-Ethyl-p-menthane-3-carboxamide structure
CAS No.
39711-79-0
Chemical Name:
N-Ethyl-p-menthane-3-carboxamide
Synonyms
WS-3;Menthol Carboxamide;ETHYL MENTHANE CARBOXAMIDE;Cooling Agent WS-3;N,2,3-trimethyl-2isopropl butanamide;FEMA 3455;Cooling taste agent ws-23;N-Ethyl-PARA-Menthan-3-Carboxamide;N-ETHYL-2-ISOPROPYL-5-METHYLCYCLOHEXANE CARBOXAMIDE;N-Ethyl-5-methyl-2-propan-2-ylcyclohexane-1-carboxamide
CBNumber:
CB0252522
Molecular Formula:
C13H25NO
Molecular Weight:
211.34
MDL Number:
MFCD00130071
MOL File:
39711-79-0.mol
MSDS File:
SDS
Last updated:2026-03-13 15:00:32
Product description Number Pack Size Price
N-Ethyl-2-isopropyl-5-methylcyclohexanecarboxamide 99%, FG W345501 1 each $58
N-Ethyl-2-isopropyl-5-methylcyclohexanecarboxamide 99%, FG W345501 100g $153
N-Ethyl-2-isopropyl-5-methylcyclohexanecarboxamide 99%, FG W345501 1kg $707
N-Ethyl-2-isopropyl-5-methylcyclohexanecarboxamide 99%, FG W345501 1 unit $53.48
N-Ethyl-2-isopropyl-5-methylcyclohexanecarboxamide 99%, FG W345501 1 unit $53.48
More product size
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N-Ethyl-p-menthane-3-carboxamide Properties

Melting point 87-102 °C
alpha D -49 to -54°
Boiling point 351.04°C (rough estimate)
Density 0.9305 (rough estimate)
vapor pressure 0.007Pa at 25℃
refractive index 1.4410 (estimate)
FEMA 3455 | N-ETHYL-2-ISOPROPYL-5-METHYLCYCLOHEXANE CARBOXAMIDE
storage temp. Sealed in dry,Room Temperature
solubility DMSO: ≥ 100 mg/mL (473.17 mM); Water: < 0.1 mg/mL (insoluble)
pka 16.27±0.60(Predicted)
form powder to crystal
color White to Almost white
Odor at 25.00 % in dipropylene glycol. mild mentholic minty
Odor Type minty
biological source synthetic
Water Solubility insoluble
Merck 14,3825
JECFA Number 1601
Major Application flavors and fragrances
Cosmetics Ingredients Functions TONIC
InChI 1S/C13H25NO/c1-5-14-13(15)12-8-10(4)6-7-11(12)9(2)3/h9-12H,5-8H2,1-4H3,(H,14,15)
InChIKey VUNOFAIHSALQQH-UHFFFAOYSA-N
SMILES CCNC(=O)C1CC(C)CCC1C(C)C
LogP 2.902 at 25℃
CAS DataBase Reference 39711-79-0(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS) N-ETHYL-2-ISOPROPYL-5-METHYLCYCLOHEXANE CARBOXAMIDE
EWG's Food Scores 1
FDA UNII 6S7S02945H
EPA Substance Registry System Cyclohexanecarboxamide, N-ethyl-5-methyl-2-(1-methylethyl)- (39711-79-0)
UNSPSC Code 12164502
NACRES NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS05,GHS07
Signal word  Danger
Hazard statements  H302-H318
Precautionary statements  P264-P270-P280-P301+P312-P305+P351+P338-P501
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi,Xn
Risk Statements  36-41-22
Safety Statements  39-26
WGK Germany  2
TSCA  TSCA listed
HS Code  29242990
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Dam. 1
Toxicity LD50 in mice, rats (g/kg): 5.3, 2.9 orally (Parrish)
NFPA 704
0
2 0

N-Ethyl-p-menthane-3-carboxamide price More Price(29)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich W345501 N-Ethyl-2-isopropyl-5-methylcyclohexanecarboxamide 99%, FG 39711-79-0 1 each $58 2026-03-19 Buy
Sigma-Aldrich W345501 N-Ethyl-2-isopropyl-5-methylcyclohexanecarboxamide 99%, FG 39711-79-0 100g $153 2026-03-19 Buy
Sigma-Aldrich W345501 N-Ethyl-2-isopropyl-5-methylcyclohexanecarboxamide 99%, FG 39711-79-0 1kg $707 2026-03-19 Buy
Sigma-Aldrich W345501 N-Ethyl-2-isopropyl-5-methylcyclohexanecarboxamide 99%, FG 39711-79-0 1 unit $53.48 2025-07-31 Buy
Sigma-Aldrich W345501 N-Ethyl-2-isopropyl-5-methylcyclohexanecarboxamide 99%, FG 39711-79-0 1 unit $53.48 2025-07-31 Buy
Product number Packaging Price Buy
W345501 1 each $58 Buy
W345501 100g $153 Buy
W345501 1kg $707 Buy
W345501 1 unit $53.48 Buy
W345501 1 unit $53.48 Buy

N-Ethyl-p-menthane-3-carboxamide Chemical Properties,Uses,Production

Chemical Properties

white crystalline powder

Chemical Properties

N-ethyl-p-menthane-3-carboxamide is an odorless white, crystalline solid. The compound has a strong and clear physiological cooling effect and is used mainly in oral care products.

Chemical Properties

Slight menthol-like cooling effect aroma

Uses

Physiological coolant in foods, beverages, toiletries, cosmetics and pharmaceuticals.

Uses

N-Ethyl-p-menthane-3-carboxamide is a selective transient receptor potential melastatin-8 ligand.

Definition

ChEBI: Ethyl menthane carboxamide is a p-menthane monoterpenoid.

Aroma threshold values

Aroma characteristics at 1.0%. Virtually odorless

Taste threshold values

Taste characteristics at 10 to 100 ppm. Intense lingering cooling. The cooling sensation builds slow but steadily and grows to a lingering cooling mouthfeel with a slightly camphoraceous and minty character.

Flammability and Explosibility

Not classified

Trade name

Winsense WS-3 (Renessenz)

Biological Activity

Cooling agent that is an agonist at TRPM8 receptors (EC 50 = 3.7 μ M).

Synthesis

0.89 g (0.0091 mol) of polyphosphoric acid (85%) and 0.42 g (0.0091 mol) of ethanol were weighed. 0.54 g (0.0046 mol) of diethylcarbonate was added dropwise slowly while cooling in an ice bath, wherein the temperature increases slightly. After about 5 minutes, 0.5 g (0.0030 mol) of p-menthane-3-carbonitrile was added. The reaction solution was heated and stirred for 102 hours at 150C. At the end of the reaction by GC, about 70% of desired N-Ethyl-p-menthane-3-carboxamide was formed.Synthesis_39711-79-0Fig The synthetic method 1 of N-Ethyl-p-menthane-3-carboxamide

N-Ethyl-p-menthane-3-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

N-Ethyl-p-menthane-3-carboxamide Suppliers

Global( 375)Suppliers
Supplier Tel Email Country ProdList Advantage
Changsha Hongyuxiang Chemical Co., Ltd 		+8613757949618 info@hoyoshee.com China 105 58
Jinan Finer Chemical Co., Ltd
+86-531-88989536 +86-15508631887 sales@finerchem.com China 2952 58
Nantong Chem-land Co.,Ltd.
+undefined13862903883 sales@chem-land.com China 61 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8742 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-81148696; +8617392709771 1097@dideu.com China 3996 58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		+8613343047651 admin@zlchemi.com China 3692 58
JINING XINHE CHEMICAL CO., LTD 		+8615318402391 sales@xinhepharma.com China 809 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29640 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21593 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Supplier Advantage
Changsha Hongyuxiang Chemical Co., Ltd 		58
Jinan Finer Chemical Co., Ltd
58
Nantong Chem-land Co.,Ltd.
58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		58
JINING XINHE CHEMICAL CO., LTD 		58
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60

Related articles

View Lastest Price from N-Ethyl-p-menthane-3-carboxamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-Ethyl-p-menthane-3-carboxamide pictures 2026-03-20 N-Ethyl-p-menthane-3-carboxamide
39711-79-0
 US $10.00 / kg 1kg 99% 100 mt Hebei Chuanghai Biotechnology Co., Ltd
TRPM8 antagonist WS-3 pictures 2026-03-13 TRPM8 antagonist WS-3
39711-79-0
 US $29.00 / mL 98.00% 10g TargetMol Chemicals Inc.
N-Ethyl-p-menthane-3-carboxamide pictures 2025-12-24 N-Ethyl-p-menthane-3-carboxamide
39711-79-0
 US $0.10 / KG 1KG 99.0% 1000 tons Shaanxi Dideu Medichem Co. Ltd

N-Ethyl-p-menthane-3-carboxamide Spectrum

N-Ethyl-p-menthane-3-carboxamide(39711-79-0)MSN-Ethyl-p-menthane-3-carboxamide(39711-79-0)1HNMR

39711-79-0(N-Ethyl-p-menthane-3-carboxamide)Related Search:

Polyacrylamide Ethyl cellulose Acrylamide Basic Violet 1 Kresoxim-methyl
Methyl acetate Formamide Methylparaben Isopropyl acetate N,N-Dimethylformamide
Acetamide Methyl acrylate Polyamide Methanol Ethyl acetate
Isopropyl alcohol Acetonitrile Ethyl acrylate

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Cooling taste agent ws-23 N,2,3-trimethyl-2isopropl butanamide N-Ethyl-2-(isopropyl)-5-methylcyclohexanecarboxamide N-Ethyl-5-methyl-2-(1-methylethyl)-cyclohexane-carboxamide Ethyl menthane carboxamide Framidice 3 Menthol Carboxamide WS-3 FEMA 3455 WS-3 Menthol Carboxamide N-Ethyl-PARA-Menthan-3-Carboxamide TRPM8 antagonist WS-3 Cooling Agent WS-3 N-ETHYL-5-METHYL-2-(1-METHYLETHYL)-CYCLOHEXANE-CARBOXAMIDE N-ETHYL-5-METHYL-2-(1-METHYLETHYL)-CYCLOHEXANE-CARBOXYAMIDE N-ETHYL 5-METHYL-2-ISO-PROPYLCYCLOHEXANECARBOXAMIDE N-ETHYL-4-MENTHANE-3-CARBOXAMIDE N-ETHYL-2-ISOPROPYL-5-METHYLCYCLOHEXANE CARBOXAMIDE N-ETHYL-P-MENTHAN 3-CARBOXAMIDE N-ETHYL-P-MENTHANE-3-CARBOXAMIDE ETHYL MENTHANE CARBOXAMIDE n-ethyl-5-methyl-2-(1-methylethyl)-cyclohexanecarboxamid MENTHANE CARBOXAMIDE N-Ethyl-hexahydro-p-cymene-3-carboxamide Cyclohexanecarboxamide, N-ethyl-5-methyl-2-(1-methylethyl)- N-ETHYL-PARA-MENTHANE-3-CARBOXAMIDE N-Ethyl-2-(isopropyl)-5-methylcyclohexancarboxamid N-Ethyl-p-methane-3-carboxamide, Ethyl menthane carboxamide, Framidice 3, Menthol Carboxamide WS-3 Menthol Carboxamide WS-3 N-Ethyl-5-methyl-2-propan-2-ylcyclohexane-1-carboxamide N-Ethyl-2-isopropyl-5-methylcyclohexane-1-carboxamide N-Ethyl-p-menthane-3-carboxamide,99% Ethyl menthane carboxamide Framidice 3 N-Ethyl-p-menthane-3 TIMTEC-BB SBB008527 CoolingSensate WS 3 N-ETHYL-PARA-MENTHAN-3-CARBOXAMIDE cooling agent (1R,2R,5S)-N-ethyl-5-methyl-2-propan-2-yl-1-cyclohexanecarboxamide N-Ethyl-p-menthane-3-carboxamide> N-Ethyl-p-menthane-3-carboxamide（Cooling taste agent WS-23） -p-menthane-3-carboxamide N-Ethyl-p-menthane-3-carboxamide ISO 9001：2015 REACH Cool taste WS - 3 N-ETHYL-P-MENTHAN-3-CARBOXAMIDE(WS-3) N-Ethyl-2-isopropyl-5-methylcyclohexane ? ?carboxamide(WS-3) (1R,2S,5R)-N-Ethyl-p-menthane-3-carboxamide N-Ethyl-p-menthane-3-carboxamide (WS-3) TRPM8 antagonist WS-3, 10 mM in DMSO N-Ethyl-2-isopropyl-5-methylcyclohexanecarboxamide 39711-79-0