Tert-butyl 3-bromo-6-chloropicolinate
- CAS No.
- 1235036-15-3
- Chemical Name:
- Tert-butyl 3-bromo-6-chloropicolinate
- Synonyms
- 3-Bromo-6-chloro-2-Boc-pyridine;Tert-butyl 3-bromo-6-chloropicolinate;Tert-butyl 3-bromo-6-chloropyridolinate;3-Bromo-6-chloropyridine Tert-Butyl formate;tert-butyl 3-bromo-6-chloropyridine-2-carboxylate;3-Bromo-6-Chloropyridinecarboxylic acid tert butyl ester;3-Bromo-6-chloro-pyridine-2-carboxylic acid tert-butyl ester;3-bromo-6-chloro-2-pyridinecarboxylic acid 1,1-dimethylethyl ester;2-Pyridinecarboxylic acid, 3-broMo-6-chloro-, 1,1-diMethylethyl ester;1,?1-?Dimethylethyl Ester 3-?Bromo-?6-?chloro-?2-?Pyridinecarboxylic Acid
- CBNumber:
- CB02534956
- Molecular Formula:
- C10H11BrClNO2
- Molecular Weight:
- 292.56
- MDL Number:
- MFCD19443279
- MOL File:
- 1235036-15-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 334.3±37.0 °C(Predicted) |
|---|---|
| Density | 1.475±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | -3.48±0.10(Predicted) |
| Appearance | White to off-white Solid |
| InChI | InChI=1S/C10H11BrClNO2/c1-10(2,3)15-9(14)8-6(11)4-5-7(12)13-8/h4-5H,1-3H3 |
| InChIKey | JKGXLKXQUDHRLL-UHFFFAOYSA-N |
| SMILES | C1(C(OC(C)(C)C)=O)=NC(Cl)=CC=C1Br |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P330 |
| RIDADR | UN2811 |
Tert-butyl 3-bromo-6-chloropicolinate price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 122243 | tert-Butyl 3-Bromo-6-chloropyridine-2-carboxylate | 1235036-15-3 | 1.00g | $364 | 2026-05-18 | Buy |
| Synthonix | B11976 | tert-Butyl 3-Bromo-6-chloropyridine-2-carboxylate 97.0% | 1235036-15-3 | 1g | $36 | 2026-05-06 | Buy |
| Synthonix | B11976 | tert-Butyl 3-Bromo-6-chloropyridine-2-carboxylate 97.0% | 1235036-15-3 | 5g | $100 | 2026-05-06 | Buy |
| Synthonix | B11976 | tert-Butyl 3-Bromo-6-chloropyridine-2-carboxylate 97.0% | 1235036-15-3 | 10g | $200 | 2026-05-06 | Buy |
| Synthonix | B11976 | tert-Butyl 3-Bromo-6-chloropyridine-2-carboxylate 97.0% | 1235036-15-3 | 25g | $500 | 2026-05-06 | Buy |
Tert-butyl 3-bromo-6-chloropicolinate Chemical Properties, Uses, Production
Uses
1,1-Dimethylethyl Ester 3-Bromo-6-chloro-2-Pyridinecarboxylic Acid was used to study expeditious synthesis of isoquinolones and isocoumarins.
Synthesis
929000-66-8
75-65-0
1235036-15-3
GENERAL STEPS: Toluenesulfonyl chloride (7.7 g, 40.4 mmol) was slowly added to a solution of tert-butanol (33 mL) containing 3-bromo-6-chloro-2-pyridinecarboxylic acid (4 g, 17 mmol) and pyridine (9.2 mL, 114 mmol) at 0 °C. The reaction mixture was then stirred continuously at room temperature for 12 hours. Upon completion of the reaction, saturated sodium bicarbonate solution was added and extracted with ethyl acetate (3 times). The organic phases were combined, washed with saturated brine and dried over anhydrous sodium sulfate. The organic phase was concentrated under reduced pressure to afford the target product tert-butyl 3-bromo-6-chloropyridine-2-carboxylate (121A) in quantitative yield. The resulting product can be used in subsequent reactions without further purification. Product characterization data: 1H NMR (300 MHz, CDCl3) δ 7.85 (d, 1H), 7.26 (d, 1H), 1.63 (s, 9H).
References
[1] Patent: WO2010/80503, 2010, A1. Location in patent: Page/Page column 232-233
[2] Patent: WO2010/80503, 2010, A1. Location in patent: Page/Page column 199
[3] Patent: US2013/96120, 2013, A1. Location in patent: Paragraph 0878
[4] Patent: US2013/96121, 2013, A1. Location in patent: Paragraph 1224
[5] Patent: WO2014/28381, 2014, A1. Location in patent: Page/Page column 112
Tert-butyl 3-bromo-6-chloropicolinate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Ningjitong Pharmaceutical Biotechnology Co., Ltd | 0-19710401727 19710401727 | 3805829626@QQ.COM | China | 1544 | 58 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Nan Jing Dirise Chemcial Co.,LTD | 025-52161033 15312098939 | 2432674894@qq.com | China | 585 | 64 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| Tianjin Anhao Biological Technology Co., Ltd. | sales@ahpharmatech.com | China | 5734 | 55 | |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| Shanghai YuanQi Biotechnology Co., Ltd. | +86-2332782371 +86-18120098618 | sales@adobechem.com | China | 1250 | 50 |
| SuZhou ShiYa Biopharmaceuticals, Inc. | 0512-0512-52358471 17715136450 | sales@shiyabiopharm.com | China | 9814 | 58 |
View Latest Price from Tert-butyl 3-bromo-6-chloropicolinate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | Tert-butyl 3-bromo-6-chloropicolinate
1235036-15-3
|
$70.00-1000.00 | 5g | 99% | 50 | Zibo Hangyu Biotechnology Development Co., Ltd | |
 |
2020-02-02 | Tert-butyl 3-bromo-6-chloropicolinate
1235036-15-3
|
$1.00 | 1g | 99% | 200g | Career Henan Chemical Co |
-
- Tert-butyl 3-bromo-6-chloropicolinate
1235036-15-3
- $70.00-1000.00
- 99%
- Zibo Hangyu Biotechnology Development Co., Ltd
-
- Tert-butyl 3-bromo-6-chloropicolinate
1235036-15-3
- $1.00
- 99%
- Career Henan Chemical Co
