DIHYDROFISETIN
- CAS No.
- 20725-03-5
- Chemical Name:
- DIHYDROFISETIN
- Synonyms
- FUSTIN;FUSTIN(SH);FUSTIN 97%;DIHYDROFISETIN;2,3-DIHYDROFISETH;2,3-DIHYDROFISETIN;5-Deoxydihydrouercetin;3',4',7-TRIHYDROXYFLAVANONOL;3,3',4',7-TETRAHYDROXYFLAVANONE;3,7,3',4'-TETRAHYDROXYFLAVANONE
- CBNumber:
- CB0256494
- Molecular Formula:
- C15H12O6
- Molecular Weight:
- 288.25
- MDL Number:
- MFCD00075647
- MOL File:
- 20725-03-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Fustin ≥98% | 36273 | 1mg | $32 |
| Fustin ≥98% | 36273 | 5mg | $118 |
| Fustin ≥98% | 36273 | 10mg | $156 |
| Fustin ≥98% | 36273 | 25mg | $349 |
| 3,3'',4'',7-Tetrahydroxyflavanone | T795753 | 10mg | $130 |
| More product size | |||
| Melting point | 216-217°C |
|---|---|
| storage temp. | -20°C |
| solubility | Acetone: soluble,Chloroform: soluble,Dichloromethane: soluble,DMSO: soluble,Ethyl Acetate: soluble |
| pka | 7.59±0.60(Predicted) |
| form | A solid |
| Boiling point | 644.2±55.0 °C(Predicted) |
| Density | 1.599±0.06 g/cm3(Predicted) |
| color | White to off-white |
| LogP | 0.870 |
| EWG's Food Scores | 1 |
| FDA UNII | 4994C1X19A |
DIHYDROFISETIN price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 36273 | Fustin ≥98% | 20725-03-5 | 1mg | $32 | 2026-04-30 | Buy |
| Cayman Chemical | 36273 | Fustin ≥98% | 20725-03-5 | 5mg | $118 | 2026-04-30 | Buy |
| Cayman Chemical | 36273 | Fustin ≥98% | 20725-03-5 | 10mg | $156 | 2026-04-30 | Buy |
| Cayman Chemical | 36273 | Fustin ≥98% | 20725-03-5 | 25mg | $349 | 2026-04-30 | Buy |
| TRC | T795753 | 3,3'',4'',7-Tetrahydroxyflavanone | 20725-03-5 | 10mg | $130 | 2021-12-16 | Buy |
DIHYDROFISETIN Chemical Properties,Uses,Production
Uses
Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) is a potent amyloid β (Aβ) inhibitor. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases the expression of acetylcholine (ACh) levels, choline acetyltransferase (ChAT) activity, and ChAT gene induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) decreases in acetyl cholinesterase (AChE) activity and AChE gene expression induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases muscarinic M1 receptor gene expression and muscarinic M1 receptor binding activity. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) can be used for Alzheimer's disease research[1].
Definition
ChEBI: A dihydroflavonol that is the 2,3-dihydro derivative of fisetin.
in vivo
Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) (50-100 mg/kg; p.o.; daily, for 11days; Aβ-treated C57BL/6 mice) attenuates Aβ (1-42)-induced impairments in conditioned fear learning and passive avoidance behavior[1].
Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) (50-100 mg/kg; p.o.; daily, for 11days; Aβ-treated C57BL/6 mice) alters Aβ (1-42)-induced changes in ACh level and AChE and ChAT activity and gene expression[1].
Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) (50-100 mg/kg; p.o.; daily, for 11days; Aβ-treated C57BL/6 mice) increases Aβ (1-42)-induced reduction in M1 receptor mRNA and protein expression in Aβ-treated C57BL/6 mice. Fustin increases p-ERK and p-CREB expression in Aβ-treated C57BL/6 mice[1].
| Animal Model: | Aβ-treated C57BL/6 mice[1] |
| Dosage: | 50 and 100 mg/kg |
| Administration: | Oral administration;daily, for 11days |
| Result: | Decreased freezing response in Aβ-treated C57BL/6 mice. |
| Animal Model: | Aβ-treated C57BL/6 mice[1] |
| Dosage: | 50 and 100 mg/kg |
| Administration: | Oral administration;daily, for 11days |
| Result: | Increased the expression of Ach, ChAT gene and ChAT activity. Decreased the expression of AChE gene and AChE activity. |
| Animal Model: | Aβ-treated C57BL/6 mice[1] |
| Dosage: | 50 and 100 mg/kg |
| Administration: | Oral administration;daily, for 11days |
| Result: | Increased gene expression of M2- , M3- ,M4-, M5-, α4β, α7-receptor, p-ERK and p-CREB. |
References
[1] Jin CH, et, al. Fustin flavonoid attenuates beta-amyloid (1-42)-induced learning impairment. J Neurosci Res. 2009 Dec;87(16):3658-70. DOI:10.1002/jnr.22159
DIHYDROFISETIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29816 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12373 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39040 | 58 |
| Zhengzhou Anbu Chem Co.,Ltd | +86-0371-88006763; +8615988602810 | sales@anbuchem.com | China | 3015 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20124 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39927 | 58 |
| Chemwill Asia Co.,Ltd. | 86-21-51086038 | chemwill_asia@126.com | CHINA | 23912 | 58 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40228 | 62 |
View Lastest Price from DIHYDROFISETIN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | DIHYDROFISETIN
20725-03-5
|
US $29.00 / KG | 10KG | 99% | 10000kg | Career Henan Chemical Co |
-
- DIHYDROFISETIN
20725-03-5
- US $29.00 / KG
- 99%
- Career Henan Chemical Co
