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Rhynchophylline

Rhynchophylline Structure
Rhynchophylline structure
CAS No.
76-66-4
Chemical Name:
Rhynchophylline
Synonyms
NSC-21731;mitrinermin;MITRINERMINE;UNCARINE D(P);rhyncophylline;rhynchophyllin;RHYNCHOPHYLLINE;RHYNCHOLPHYLLINE;Hook vine extract;Rhynchophylline98%
CBNumber:
CB0256535
Molecular Formula:
C22H28N2O4
Molecular Weight:
384.47
MDL Number:
MFCD00221748
MOL File:
76-66-4.mol
MSDS File:
SDS
Last updated:2025-10-29 15:43:00
Product description Number Pack Size Price
Rhynchophylline phyproof® Reference Substance PHL80526 10 mg $689
Rhynchophylline R414180 100mg $315
Rhynchophylline 300890 20mg $433
METHYL (E)-2-[(6'R,7'S)-6'-ETHYL-2-OXOSPIRO[1H-INDOLE-3,1'-3,5,6,7,8,8A-HEXAHYDRO-2H-INDOLIZINE]-7'-YL]-3-METHOXYPROP-2-ENOATE 95.00% CHM0170796 5MG $497.61
Rhynchophylline FR42770 250mg $500
More product size
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Rhynchophylline Properties

Melting point 216°; mp 197-199° (Ban et al., loc. cit.)
alpha D13 -14.7° (c = 2.5 in chloroform)
Boiling point 560.8±50.0 °C(Predicted)
Density 1.23
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka 6.4(at 25℃)
form Solid
color White to Off-White
λmax 247nm(lit.)
Merck 14,8197
Stability Hygroscopic
InChIKey DAXYUDFNWXHGBE-QCJVZUPCSA-N
LogP 3.311 (est)
CAS DataBase Reference 76-66-4
FDA UNII 46BQ79VJ8D

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H300
Precautionary statements  P264-P270-P301+P310-P321-P330-P405-P501
RTECS  GN1600000
HS Code  29399990
NFPA 704
0
4 0

Rhynchophylline price More Price(32)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHL80526 Rhynchophylline phyproof® Reference Substance 76-66-4 10 mg $689 2026-03-19 Buy
TRC R414180 Rhynchophylline 76-66-4 100mg $315 2021-12-16 Buy
Usbiological 300890 Rhynchophylline 76-66-4 20mg $433 2021-12-16 Buy
American Custom Chemicals Corporation CHM0170796 METHYL (E)-2-[(6'R,7'S)-6'-ETHYL-2-OXOSPIRO[1H-INDOLE-3,1'-3,5,6,7,8,8A-HEXAHYDRO-2H-INDOLIZINE]-7'-YL]-3-METHOXYPROP-2-ENOATE 95.00% 76-66-4 5MG $497.61 2021-12-16 Buy
Biosynth Carbosynth FR42770 Rhynchophylline 76-66-4 250mg $500 2021-12-16 Buy
Product number Packaging Price Buy
PHL80526 10 mg $689 Buy
R414180 100mg $315 Buy
300890 20mg $433 Buy
CHM0170796 5MG $497.61 Buy
FR42770 250mg $500 Buy

Rhynchophylline Chemical Properties,Uses,Production

Chemical Properties

Soluble in chloroform, acetone, ethanol, benzene, slightly soluble in ether and ethyl acetate, almost insoluble in petroleum ether. Derived from the hooked branches of Uncaria rhynchopylla (Miq.) Jacks.

Uses

Rhynchophylline is a novel erythropoietin-producing hepatocellular A4 (EphA4) inhibitor.

Definition

ChEBI: A natural product found in Uncaria macrophylla.

in vivo

Rhynchophylline (10 and 30 mg/kg, i.p., once daily for 4 days) protects rats from pMCAO surgery induced ischemic brain damage[2].
Rhynchophylline (100 μM, 2 μL, injected bilaterally in the hippocamp) shows neuroprotective effects against Aβ1-42-induced neurotoxicity in rats[5].
Rhynchophylline (50 mg/kg, p.o., daily, 3-4 weeks) inhibits EphA4 activation in the hippocampus of APP/PS1 mice[6].

Animal Model:Aβ1-42(1.6 μM, 2 μL) treated rats[5]
Dosage:100 μM, 2 μL
Administration:injected bilaterally in the hippocamp
Result:Rescued the soluble Aβ1-42-induced spatial learning and memory deficits.
Inhibited Aβ1-42-induced excessive activation of extrasynaptic NMDARs.

References

See Rhyncophylline

Rhynchophylline Preparation Products And Raw materials

Raw materials

Preparation Products

Rhynchophylline Suppliers

Global( 283)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8743 58
Henan Bao Enluo International TradeCo.，LTD 		+86-17331933971 deasea125996@gmail.com China 2472 58
Shaanxi Haibo Biotechnology Co., Ltd 		+undefined18602966907 qinhe02@xaltbio.com China 997 58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD 		+86-15350851019; +8615350851019 admin@86-ss.com China 999 58
Shaanxi Xianhe Biotech Co., Ltd 		+86-17709210191; +8617709210191 Jerry@xhobio.com China 905 58
Shanghai Zheyan Biotech Co., Ltd. 		18017610038 zheyansh@163.com CHINA 3619 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29830 58
Chengdu Biopurify Phytochemicals Ltd. 		+86-28-82633860; +8618080483897 sales@biopurify.com China 3751 58
Nanjing Dolon Biotechnology Co.,Ltd. 		18905173768 52513593@qq.com CHINA 2972 58
NanJing Spring & Autumn Biological Engineering CO., LTD. 		+8613815430202 sale02@cqherb.com CHINA 376 58
Supplier Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		58
Henan Bao Enluo International TradeCo.，LTD 		58
Shaanxi Haibo Biotechnology Co., Ltd 		58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD 		58
Shaanxi Xianhe Biotech Co., Ltd 		58
Shanghai Zheyan Biotech Co., Ltd. 		58
career henan chemical co 		58
Chengdu Biopurify Phytochemicals Ltd. 		58
Nanjing Dolon Biotechnology Co.,Ltd. 		58
NanJing Spring & Autumn Biological Engineering CO., LTD. 		58

View Lastest Price from Rhynchophylline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Rhynchophylline pictures 2026-03-22 Rhynchophylline
76-66-4
 US $0.00 / MG 20MG ≥98% HPLC 100KG Changsha Staherb Natural Ingredients Co., Ltd.
Rhynchophylline pictures 2026-03-20 Rhynchophylline
76-66-4
 US $10.00 / KG 1KG 99% 5tons Hebei Chuanghai Biotechnology Co., Ltd
Rhynchophylline pictures 2026-03-20 Rhynchophylline
76-66-4
 US $0.00 / kg 1kg 0.99 1000kg Shaanxi Xianhe Biotech Co., Ltd
  • Rhynchophylline pictures
  • Rhynchophylline
    76-66-4
  • US $0.00 / MG
  • ≥98% HPLC
  • Changsha Staherb Natural Ingredients Co., Ltd.
  • Rhynchophylline pictures
  • Rhynchophylline
    76-66-4
  • US $10.00 / KG
  • 99%
  • Hebei Chuanghai Biotechnology Co., Ltd

Rhynchophylline Spectrum

Rhynchophylline(76-66-4)MSRhynchophylline(76-66-4)1HNMR

76-66-4(Rhynchophylline)Related Search:

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UNCARINE D INDOLIZINE Anti-isorhynchophylline N-oxide

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RHYNCHOLPHYLLINE RHYNCHOPHYLLINE MITRINERMINE 16e,20-alpha)-(7-bet mitrinermin Rhynchophylline 76-66-4 Hook vine extract rhynchophyllin UNCARINE D(P) rhyncophylline Methyl (E)-2-[(6'R,7'S)-6'-ethyl-2-oxospiro[1H-indole-3,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine]-7'-yl]-3-methoxyprop-2-enoate Spiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid,6'-ethyl-1,2,2',3',6',7',8',8'a-octahydro-α-(methoxymethylene)-2-oxo-,methyl ester, (αE,1'R,6'R,7'S,8'aS)- (7R,16E,20R)-16,17-Didehydro-17-methoxy-2-oxocorynoxan-16-carboxylic acid methyl ester NSC-21731 Rhynchophylline, 98%, from Uncaria rhynchophylla (Miq.) Miq. ex Havil. Rhynchophylline > Rhynchophylline USP/EP/BP Rhynchophylline98% methyl (E)-2-[(3R,6'R,7'S,8'aS)-6'-ethyl-2-oxospiro[1H-indole-3,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine]-7'-yl]-3-methoxyprop-2-enoate Methyl (E)-2-((3R,6'R,7'S,8a'S)-6'-ethyl-2-oxo-2',3',6',7',8',8a'-hexahydro-5'H-spiro[indoline-3,1'-indolizin]-7'-yl)-3-methoxyacrylate Rhynchophylline-RM Rhynchophylline, 10 mM in DMSO Rhynchophylline - Bio-X ? 76-66-4 C22H28N2O4 chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract Alkaloids API