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5'-Deoxy-5-fluorocytidine

5'-Deoxy-5-fluorocytidine structure

CAS No.: 66335-38-4

Chemical Name:: 5'-Deoxy-5-fluorocytidine

Synonyms: 5'-DFCR;4-aMino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-Methyltetrahydrofuran-2-yl)-5-fluoropyriMidin-2(1H)-one;5-F-5'-dC;[2H2]-5-DFCR;Capecitabine-1;Capecitabine Imp.A;Deoxy fluorocytidine;Capecitabine USP RC A;Capecitabine USP IMp.A;Capecitabine Impurity 1

CBNumber:: CB0258261

Molecular Formula:: C9H12FN3O4

Molecular Weight:: 245.21

MDL Number:: MFCD07369278

MOL File:: 66335-38-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 17:36:52

Product description	Number	Pack Size	Price
Capecitabine impurity A European Pharmacopoeia (EP) Reference Standard	Y0001643	5 mg	$241
Capecitabine Related Compound A certified reference material, pharmaceutical secondary standard	PHR2849	50 mg	$576
Capecitabine impurity A European Pharmacopoeia (EP) Reference Standard	Y0001643	Y0001643	$218
5'-Deoxy-5-fluorocytidine >98.0%(HPLC)(T)	D4342	1g	$41
5'-Deoxy-5-fluorocytidine >98.0%(HPLC)(T)	D4342	5g	$125
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5'-Deoxy-5-fluorocytidine Properties

Melting point	196-198°C
Boiling point	437.9±55.0 °C(Predicted)
Density	1.84±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
pka	13.65±0.70(Predicted)
form	Solid
color	White to Light Beige
Stability	HYGROSCOPIC
Major Application	pharmaceutical small molecule
InChI	1S/C9H12FN3O4/c1-3-5(14)6(15)8(17-3)13-2-4(10)7(11)12-9(13)16/h2-3,5-6,8,14-15H,1H3,(H2,11,12,16)/t3-,5-,6-,8-/m1/s1
InChIKey	YSNABXSEHNLERR-ZIYNGMLESA-N
SMILES	FC1=CN(C(=O)N=C1N)[C@@H]2O[C@@H]([C@H]([C@H]2O)O)C
CAS DataBase Reference	66335-38-4(CAS DataBase Reference)
FDA UNII	8RWB05I6ON
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS08

Signal word

Danger

Hazard statements

H360-H350

Precautionary statements

P261-P305+P351+P338

Hazard Codes

Xn,Xi

Risk Statements

20/21/22-36/37/38

Safety Statements

26-36-37/39-24/25

WGK Germany

WGK 3

HS Code

29349990

Storage Class

11 - Combustible Solids

NFPA 704

	0
2		0

5'-Deoxy-5-fluorocytidine price More Price(68)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	Y0001643	Capecitabine impurity A European Pharmacopoeia (EP) Reference Standard	66335-38-4	5 mg	$241	2026-04-30	Buy
Sigma-Aldrich	PHR2849	Capecitabine Related Compound A certified reference material, pharmaceutical secondary standard	66335-38-4	50 mg	$576	2026-04-30	Buy
Sigma-Aldrich	Y0001643	Capecitabine impurity A European Pharmacopoeia (EP) Reference Standard	66335-38-4	Y0001643	$218	2023-06-20	Buy
TCI Chemical	D4342	5'-Deoxy-5-fluorocytidine >98.0%(HPLC)(T)	66335-38-4	1g	$41	2026-04-30	Buy
TCI Chemical	D4342	5'-Deoxy-5-fluorocytidine >98.0%(HPLC)(T)	66335-38-4	5g	$125	2026-04-30	Buy

Product number	Packaging	Price	Buy
Y0001643	5 mg	$241	Buy
PHR2849	50 mg	$576	Buy
Y0001643	Y0001643	$218	Buy
D4342	1g	$41	Buy
D4342	5g	$125	Buy

5'-Deoxy-5-fluorocytidine Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

A metabolite of Capecitabine.

Definition

ChEBI: 5'-Deoxy-5-fluorocytidine is a N-glycosyl compound.

Synthesis

154361-50-9

66335-38-4

1. Pentyl (1-((2R,3R,4S,5R)-3,4-dihydroxy-5-methyltetrahydrofuran-2-yl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl)carbamate (capecitabine, 4.5 g, 12.5 mmol) was suspended with potassium carbonate (8.8 g, 63.77 mmol) in methanol (250 mL) and N,N- dimethylformamide (DMF, 10 mL). The mixture was heated to reflux for 24 hours. Upon completion of the reaction, the reaction solution was cooled and concentrated to dryness under reduced pressure at below 45 °C. The residue was dissolved in hot methanol, filtered and washed with hot methanol. The filtrate was pre-adsorbed on silica gel and purified by fast column chromatography using 50% methanol/ethyl acetate as eluent to afford 1-[3,4-dihydroxy-5-methyltetrahydrofuran-2-yl]-4-amino-1H-pyrimidin-2-one (3.0 g, 90% yield). 2. The above product (3.0 g) was suspended in chloroform (125 mL) and heated to 50 °C. The product (3.0 g) was added to the mixture. Acetic acid (2 mL, 34 mmol) and acetyl chloride (20 mL, 206 mmol) were added sequentially and stirred at 50 °C for 7 hours, followed by continued stirring at 20 °C for 72 hours. At the end of the reaction, ether (100 mL) was added, the solid was collected by filtration and washed with ether to afford 1-[3,4-diacetoxy-5-methyltetrahydrofuran-2-yl]-4-amino-1H-pyrimidin-2-one hydrochloride (4.0 g, 90% yield). 3. The above hydrochloride (2.07 g, 5.7 mmol) was dissolved in pyridine (1.4 mL, 17.4 mmol) and dichloromethane (DCM, 15 mL) with 5-nitrothiophen-2-ylmethanol (1.47 g, 9.3 mmol). A 2M toluene solution of phosgene (3.6 mL, 7.2 mmol) was slowly added at 0 °C and stirred for 2.5 h. After 2.5 h, the same amount of phosgene solution was added again and stirring was continued for 2 h at 0 °C, followed by 18 h of refrigeration. The reaction solution was partitioned with ethyl acetate and brine, the aqueous phase was extracted with ethyl acetate, the organic phases were combined, dried and concentrated under reduced pressure. The residue was purified by silica gel column chromatography with 2% methanol/DCM as eluent to give an off-white foamy product (400 mg, 14% yield). Thin layer chromatography (TLC) showed Rf=0.45 (2% methanol/ethyl acetate as unfolding agent). Liquid chromatography-mass spectrometry (LC-MS) analysis showed a retention time of 4.68 min (TFA 20-50% gradient) and a mass m/z of 201/159/143. nuclear magnetic resonance hydrogen spectra (1H NMR, 500 MHz, DMSO-d6) δ 11.20 (1H, broad single peak, NH), 8.3 (1H, broad peak, NCH=CF). 8.05 (1H, single peak, HarH), 7.30 (1H, single peak, HarH), 5.80 (1H, single peak, NCHO), 5.42 (3H, multiple peaks, HarCH2OCONH, CHOAc), 5.15 (1H, single peak, CHOAc), 4.05 (1H, multiple peaks, OCHCH3), 3.45 (2H, multiple peak, 2×CHOAc), 2.48 (3H, single peak, OAc), 2.05 (3H, single peak, OAc), 1.37 (3H, single peak, OCHCH3) ppm.

References

[1] Patent: WO2006/32921, 2006, A1. Location in patent: Page/Page column 37-38

5'-Deoxy-5-fluorocytidine synthesis

Synthesis of 5'-Deoxy-5-fluorocytidine from Capecitabine

5'-Deoxy-5-fluorocytidine Preparation Products And Raw materials

Raw materials

5'-Deoxy-5-fluoro-2',3'-O-isopropylidene-D-cytidine 2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine Capecitabine Methanol Potassium carbonate

N,N-Dimethylformamide

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Preparation Products

Capecitabine 2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine 3,4,5-TRIMETHOXYBENZAMIDE

5'-Deoxy-5-fluorocytidine Suppliers

Global( 414)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+86-15350571055	Sibel@chuanghaibio.com	China	8737	58
Hangzhou Measure Life Technology Co., LTD	13343730176	2924244016@qq.com	China	83	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1796	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21531	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	963	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10399	58
Wuhan Chemwonders Technology Inc.	027-85778276	info@chemwonders.com	CHINA	174	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114	sales@amoychem.com	China	6361	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Hangzhou Measure Life Technology Co., LTD	58
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Biochempartner	58
Shenzhen Nexconn Pharmatechs Ltd	58
Wuhan Chemwonders Technology Inc.	58
Xiamen AmoyChem Co., Ltd	58

View Lastest Price from 5'-Deoxy-5-fluorocytidine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-07	5'-Deoxy-5-fluorocytidine 66335-38-4		1kg	99%	100kg	WUHAN FORTUNA CHEMICAL CO., LTD
2026-03-20	5'-Deoxy-5-fluorocytidine 66335-38-4	$10.00	100KG	99%	100 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-05-26	5'-Deoxy-5-fluorocytidine 66335-38-4	$5.00	1kg	0.99	10000	Hebei Fengjia New Material Co., Ltd

5'-Deoxy-5-fluorocytidine
66335-38-4
$0.00
99%
WUHAN FORTUNA CHEMICAL CO., LTD

5'-Deoxy-5-fluorocytidine
66335-38-4
$10.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

5'-Deoxy-5-fluorocytidine
66335-38-4
$5.00
0.99
Hebei Fengjia New Material Co., Ltd

5'-Deoxy-5-fluorocytidine Spectrum

5'-Deoxy-5-fluorocytidine(66335-38-4)¹HNMR

66335-38-4(5'-Deoxy-5-fluorocytidine)Related Search:

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CAPECITABINE related substance USP 5'-Deoxy-5-fluoro-N-[(2-methylbutoxy)carbonyl]cytidine 5'-Deoxy-5-fluoro-N4-(isopentyloxycarbonyl)cytidine

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5'-Deoxy-5-fluoro-D-cytidine 5''-DEOXY-5-FLUOROCYTIDINE (5''-DFCR) 5-Fluoro-5’-deoxycytidine, 5’-DFCR Capecitabine Related Compound A (10 mg) (5'-deoxy-5-fluorocytidine) 5'-Deoxy-5-fluorocytidin CAPECITABINE related substance USP A Deoxy-5-fluorocytidine-D2 4-aMino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-Methyloxolan-2-yl]-5-fluoro-1,2-dihydropyriMidin-2-one Capecitabine USP IMp.A 5-F-5'-dC Capecitabine USP RC A 5-DFCR (Deoxy-5-fluorocytidine) 5-DFCR-D2 (Deoxy-5-fluorocytidine-d2) 5'-DFCR (5'-Deoxy-5-fluorocytidine) Capecitabine-1 Capecitabine EP Impurity A (USP RC A) Cytidine, 5'-deoxy-5-fluoro- Capecitabine EP Impurity A Capecitabine Impurity A(USP) Capecitabine Impurity 1 Capecitabine EP Impurity A (5'-DFCR) Deoxy fluorocytidine [2H2]-5-DFCR 5'-Deoxy-5-fluorocytidine> Capecitabine Imp.A 5'-Deoxy-5-fluorocytidine USP/EP/BP 4-Amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-methyltetrahydrofuran-2-yl)-5-fluoropyrimidin-2(1H)-one (Capecitabine Impurity) Capecitabine EP Impurity A/ Capecitabine Related Compund A Capacitabine USP Related Compound A 5-Deoxy-5-fluoroucytidineQ: What is 5-Deoxy-5-fluoroucytidine Q: What is the CAS Number of 5-Deoxy-5-fluoroucytidine Q: What is the storage condition of 5-Deoxy-5-fluoroucytidine Q: What are the applications of 5-Deoxy-5-fluoroucytidine Capecitabine Related Compound A (5''-deoxy-5-fluorocytidine) (1090717) 5’-Deoxy-5-fluorocytidine,Capecitabine related compound A Capecitabine USP Related Compound A 5'-Deoxy-5-fluorocytidine,98% 5'-Deoxy-5-fluorocytidine 5-Fluoro-5'-deoxycytidine 4-Amino-1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoropyrimidin-2(1H)-one (5'-Deoxy-5-fluorocytidine) 5'-Deoxy-5-fluorocytidine 4-Amino-1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoropyrimidin-2(1H)-one (5'-Deoxy-5-fluorocytidine) Capecitabine EP Impurity A(Capecitabine USP Related Compound A) 4-aMino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-Methyltetrahydrofuran-2-yl)-5-fluoropyriMidin-2(1H)-one 5'-DFCR 66335-38-4 82104-74-6 C9H12N3O3F C9H12O4N3F C9H12FN3O5 C9H12FN3O Heterocycles Bases & Related Reagents Nucleotides