Resorcinolnaphthalein
- CAS No.
- 41307-63-5
- Chemical Name:
- Resorcinolnaphthalein
- Synonyms
- Resorcinolnaphthalein;FTUOFHGOGJGQAB-UHFFFAOYSA-N;Resorcinolnaphthalein, 10 mM in DMSO;Spiro[1H,3H-naphtho[1,8-cd]pyran-1,9'-[9H]xanthen]-3-one, 3',6'-dihydroxy-;fibrosis,ACE2,hypertension,renal,perivascular,Resorcinolnaphthalein,reversal,inhibit,myocardial,Inhibitor,Angiotensin-converting Enzyme (ACE)
- CBNumber:
- CB02592374
- Molecular Formula:
- C24H14O5
- Molecular Weight:
- 382.36
- MDL Number:
- MOL File:
- 41307-63-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Resorcinolnaphthalein ≥98% | 13082 | 5mg | $21 |
| Resorcinolnaphthalein ≥98% | 13082 | 10mg | $38 |
| Resorcinolnaphthalein ≥98% | 13082 | 50mg | $157 |
| Resorcinolnaphthalein ≥98% | 13082 | 100mg | $274 |
| Resorcinolnaphthalein | C3931 | 100mg | $311 |
| More product size | |||
| Melting point | >290 °C |
|---|---|
| Boiling point | 688.4±55.0 °C(Predicted) |
| Density | 1.59±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | ≤20mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide |
| pka | 9.13±0.20(Predicted) |
| form | crystalline solid |
| color | Light yellow to orange |
Resorcinolnaphthalein price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 13082 | Resorcinolnaphthalein ≥98% | 41307-63-5 | 5mg | $21 | 2024-03-01 | Buy |
| Cayman Chemical | 13082 | Resorcinolnaphthalein ≥98% | 41307-63-5 | 10mg | $38 | 2024-03-01 | Buy |
| Cayman Chemical | 13082 | Resorcinolnaphthalein ≥98% | 41307-63-5 | 50mg | $157 | 2024-03-01 | Buy |
| Cayman Chemical | 13082 | Resorcinolnaphthalein ≥98% | 41307-63-5 | 100mg | $274 | 2024-03-01 | Buy |
| ApexBio Technology | C3931 | Resorcinolnaphthalein | 41307-63-5 | 100mg | $311 | 2021-12-16 | Buy |
Resorcinolnaphthalein Chemical Properties,Uses,Production
Uses
Angiotensin-converting enzyme 2 (ACE2) is an enzyme that is cardioprotective and renoprotective. Resorcinolnaphthalein increases the activity of ACE2 in vitro (EC50 = 19.5 μM). Activation of ACE2 in rats produces a decrease in blood pressure and improvement in cardiac function. In spontaneously hypertensive rats it produces a reversal of myocardial, perivascular, and renal fibrosis.[Cayman Chemical]
Biological Activity
resorcinolnaphthalein is an angiotensin-converting enzyme 2 (ace2) activator [1].angiotensin-converting enzyme 2 (ace2) has been involved in hydrolyzing angiotensin ii and opposing its actions, and plays a protective role in the pathogenesis of pulmonary arterial hypertension (pah) [2]. targeted disruption of ace2 in mice results in a severe cardiac contractility defect, increased angiotensin ii levels, and upregulation of hypoxia-induced genes in the heart [2].
in vitro
resorcinolnaphthalein enhanced ace2 activity in a dose-dependent manner [1].
in vivo
resorcinolnaphthalein caused significant activation of ace2 in both normal and diseased rats in 7 days after treatment. treatment with resorcinolnaphthalein prevented high pap, right ventricular hypertrophy and neointimal formation. resorcinolnaphthalein caused an improved endothelia-dependent vasorelaxation and decreased in proinflammatory cytokines, such as tnf-α, mcp-1, il-6, and increased in anti-inflammatory cytokine il-10 in the early stage of the pathogenesis [3]. resorcinolnaphthalein can specifically and effectively enhanced ace2 activity in rats [4]. ace2 activation by resorcinolnaphthalein showed effects on pulmonary endothelial dysfunction and neointimal formation during the development of severe pah in rats [4].
References
[1] prada j a h, ferreira a j, katovich m j, et al. structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents[j]. hypertension, 2008, 51(5): 1312-1317.
[2] crackower m a, sarao r, oudit g y, et al. angiotensin-converting enzyme 2 is an essential regulator of heart function[j]. nature, 2002, 417(6891): 822-828.
[3] haber p k, ye m, wysocki j, et al. angiotensin-converting enzyme 2–independent action of presumed angiotensin-converting enzyme 2 activatorsnovelty and significance[j]. hypertension, 2014, 63(4): 774-782.
[4] li g, liu y, zhu y, et al. ace2 activation confers endothelial protection and attenuates neointimal lesions in prevention of severe pulmonary arterial hypertension in rats[j]. lung, 2013, 191(4): 327-336.
Resorcinolnaphthalein Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39040 | 58 |
| NANJING YINGWEN BIOTECHNOLOGY CO LTD | +8613382787392 | sales@aeechem.com | China | 10000 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4827 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 89689 | 60 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2989 | 58 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 9550 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 18101056239 | 3193328036@qq.com | China | 29661 | 68 |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400-6387771-6039 18920764717 | sales@heowns.com | China | 24418 | 60 |
View Lastest Price from Resorcinolnaphthalein manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-22 | Resorcinolnaphthalein
41307-63-5
|
US $64.00-39.00 / mg | 99.25% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-04-22 | Resorcinolnaphthalein
41307-63-5
|
US $64.00-39.00 / mg | 99.25% | 10g | TargetMol Chemicals Inc. |
-
- Resorcinolnaphthalein
41307-63-5
- US $64.00-39.00 / mg
- 99.25%
- TargetMol Chemicals Inc.
-
- Resorcinolnaphthalein
41307-63-5
- US $64.00-39.00 / mg
- 99.25%
- TargetMol Chemicals Inc.
