1H-Indazole,7-broMo-5-(trifluoroMethyl)-
- CAS No.
- 1100212-66-5
- Chemical Name:
- 1H-Indazole,7-broMo-5-(trifluoroMethyl)-
- Synonyms
- 7-Bromo-5-(trifluoromethyl)-1H-indazole;1H-Indazole,7-broMo-5-(trifluoroMethyl)-
- CBNumber:
- CB02594626
- Molecular Formula:
- C8H4BrF3N2
- Molecular Weight:
- 265.03
- MDL Number:
- MFCD27939136
- MOL File:
- 1100212-66-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
1H-Indazole,7-broMo-5-(trifluoroMethyl)- price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 292161 | 7-Bromo-5-(trifluoromethyl)-1H-indazole | 1100212-66-5 | 250.00mg | $36 | 2026-05-19 | Buy |
| Matrix Scientific | 292161 | 7-Bromo-5-(trifluoromethyl)-1H-indazole | 1100212-66-5 | 1.00g | $90 | 2026-05-19 | Buy |
| Matrix Scientific | 292161 | 7-Bromo-5-(trifluoromethyl)-1H-indazole | 1100212-66-5 | 5.00g | $388 | 2026-05-19 | Buy |
| Synthonix | B16559 | 7-Bromo-5-(trifluoromethyl)-1H-indazole 97% | 1100212-66-5 | 100mg | $79 | 2026-05-06 | Buy |
| Synthonix | B16559 | 7-Bromo-5-(trifluoromethyl)-1H-indazole 97% | 1100212-66-5 | 250mg | $87 | 2026-05-06 | Buy |
1H-Indazole,7-broMo-5-(trifluoroMethyl)- Chemical Properties, Uses, Production
Uses
7-Bromo-5-(Trifluoromethyl)-1h-Indazole can be useful in the preparation of substituted heterocyclic ethers as inhibitors of NK-1 and SERT and their use in treating CNS disorders,
Synthesis
1100212-65-4
1100212-66-5
General procedure for the synthesis of 7-bromo-5-(trifluoromethyl)-1H-indazole from 2-bromo-6-methyl-4-(trifluoromethyl)aniline: to a suspension of 2-bromo-6-methyl-4-(trifluoromethyl)aniline (11.3 g, 44.5 mmol) in hydrochloric acid (8 M, 40 mL, 320 mmol) was added slowly and dropwise at -10 °C sodium nitrite (3.22 g) , 46.7 mmol) in aqueous solution (~10 mL). After 10 min of reaction, solid sodium acetate was added to neutralize the reaction solution. The neutralized solution was slowly added to a solution of 2-methyl-2-propanethiol (5.01 mL, 44.5 mmol) in ethanol (100 mL) at 0 °C. The reaction mixture was continued to be stirred at 0 °C for 30 min. Subsequently, the reaction mixture was poured on ice and extracted with ether (2×). The combined organic phases were washed sequentially with water and brine, dried over magnesium sulfate and concentrated. The concentrated residue was dissolved in dimethyl sulfoxide (25 mL) and transferred to a solution of potassium tert-butoxide (39.9 g, 356 mmol) in dimethyl sulfoxide (250 mL) through a cannula in a cold water bath (about 10 °C). After removal of the cold water bath, stirring was continued for 30 min. The reaction mixture was poured into ice/concentrated hydrochloric acid and a precipitate was precipitated. after 30 min, the solid was collected by filtration and air-dried on a filter overnight to give 10.1 g of brown solid product in 86% yield. The product was confirmed by 1H-NMR (CDCl3,500MHz) and 13C-NMR (CDCl3,126MHz) characterization.
References
[1] Patent: US2009/18132, 2009, A1. Location in patent: Page/Page column 47
1H-Indazole,7-broMo-5-(trifluoroMethyl)- Preparation Products And Raw materials
Raw materials
Preparation Products
1H-Indazole,7-broMo-5-(trifluoroMethyl)- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
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| Energy Chemical | 400-0056266 | marketing1@energy-chemical.com | China | 44927 | 58 |
| Hebei Weite Medical Technology Co., Ltd | 13180081292 13180081292 | contact@wetogethermed.com | China | 7711 | 58 |
