2-Chloro-3-Methyl-4-pyridinecarboxylic Acid
- CAS No.
- 133928-73-1
- Chemical Name:
- 2-Chloro-3-Methyl-4-pyridinecarboxylic Acid
- Synonyms
- 2-chloro-3-Methylpyridine-4-carboxylic acid;3-Methyl-2-chloroisonicotinic acid;3-Methyl-2-chloropyridine-4-carboxylic acid;3-Methyl-2-chloro-4-pyridinecarboxylic acid;2-Chloro-3-Methyl-4-pyridinecarboxylic Acid;4-Pyridinecarboxylic acid, 2-chloro-3-methyl-
- CBNumber:
- CB02603777
- Molecular Formula:
- C7H6ClNO2
- Molecular Weight:
- 171.58
- MDL Number:
- MOL File:
- 133928-73-1.mol
- MSDS File:
- SDS
| Boiling point | 412.7±40.0 °C(Predicted) |
|---|---|
| Density | 1.390±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 2.42±0.25(Predicted) |
| Appearance | White to off-white Solid |
| InChI | InChI=1S/C7H6ClNO2/c1-4-5(7(10)11)2-3-9-6(4)8/h2-3H,1H3,(H,10,11) |
| InChIKey | JYVLCHBMNCMRBO-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC=CC(C(O)=O)=C1C |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS02 |
|---|---|
| Signal word | Danger |
| Hazard statements | H315-H319-H225 |
| Precautionary statements | P501-P240-P210-P233-P243-P241-P242-P264-P280-P370+P378-P337+P313-P305+P351+P338-P362+P364-P303+P361+P353-P332+P313-P403+P235 |
| HS Code | 2933399990 |
2-Chloro-3-Methyl-4-pyridinecarboxylic Acid price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | IFA92873 | 2-Chloro-3-methylisonicotinic Acid | 133928-73-1 | 1g | $342.2 | 2026-06-04 | Buy |
| Biosynth | IFA92873 | 2-Chloro-3-methylisonicotinic Acid | 133928-73-1 | 10g | $2006 | 2026-06-04 | Buy |
| Apolloscientific | OR929238 | 2-Chloro-3-methylisonicotinic acid 97% | 133928-73-1 | 100mg | $29 | 2026-06-04 | Buy |
| Apolloscientific | OR929238 | 2-Chloro-3-methylisonicotinic acid 97% | 133928-73-1 | 250mg | $69 | 2026-06-04 | Buy |
| Apolloscientific | OR929238 | 2-Chloro-3-methylisonicotinic acid 97% | 133928-73-1 | 1g | $184 | 2026-06-04 | Buy |
2-Chloro-3-Methyl-4-pyridinecarboxylic Acid Chemical Properties, Uses, Production
Uses
2-Chloro-3-methylisonicotinic Acid is a derivative of Isonicotinic Acid (I821760) and is used as a reagent in the synthesis of N-pyridinylmethyl benzamide derivatives as anticancer agents.
Synthesis
133928-64-0
133928-73-1
Step 3: Synthesis of 2-chloro-3-methylpyridine-4-carboxylic acid A mixture of 2-chloro-N,3-dimethyl-N-phenylpyridine-4-carboxamide (2.2 g, 8.5 mmol) was mixed with a mixture of concentrated H2SO4 (23.2 mL) and water (16.8 mL), which was subsequently heated to 130 °C and kept for 46 hours. Upon completion of the reaction, the reaction mixture was cooled to room temperature and poured into ice (200 mL) and stirred until the ice was completely melted. The mixture was adjusted to alkaline (pH 8) by batchwise addition of solid Na2CO3 (50.3 g). The suspension was filtered and the filtrate was acidified to pH 3 by the addition of 6 M HCl (aq) (ca. 1.5 mL).The resulting solid was collected by filtration, washed with water (20 mL) and dried under vacuum at 40 °C for 10 h to afford 2-chloro-3-methyl-4-pyridinecarboxylic acid (779 mg, 54%) as a pink solid.LC-MS purity 100%, m/z = 171.9, 173.9; 1H NMR (500 MHz, MeOD) δ ppm 8.30 (d, J = 4.89 Hz, 1H), 7.64 (d, J = 5.04 Hz, 1H), 2.58 (s, 3H).
References
[1] Tetrahedron, 1991, vol. 47, # 9, p. 1697 - 1706
[2] Patent: WO2012/142513, 2012, A1. Location in patent: Page/Page column 427-428
2-Chloro-3-Methyl-4-pyridinecarboxylic Acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Xi 'an fanta biotechnology co., LTD | 19929974101 //1144079830; 19929974101 | 1144079830@qq.com | China | 952 | 58 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
| Hebei Summedchem Co.,Ltd | 0319-5801333-8008 15630992918 | sales@summedchem.com | China | 1000 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| Accela ChemBio Inc. | +1(858) 699-3322 | marketing@accelachem.com | United States | 6022 | 65 |
| NovoChemy Ltd. | 86-(0)21-31261262 373522135 | sales@novochemy.com | China | 6491 | 58 |
View Latest Price from 2-Chloro-3-Methyl-4-pyridinecarboxylic Acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-01-26 | 2-Chloro-3-methylisonicotinic acid
133928-73-1
|
1KG | 98.4% | 100 tons | Honest Joy Holdings Limited | ||
 |
2019-07-06 | 2-Chloro-3-Methyl-4-pyridinecarboxylic Acid
133928-73-1
|
$220.00 | 1G | 99% | Career Henan Chemical Co |
-
- 2-Chloro-3-methylisonicotinic acid
133928-73-1
- $0.00
- 98.4%
- Honest Joy Holdings Limited
-
- 2-Chloro-3-Methyl-4-pyridinecarboxylic Acid
133928-73-1
- $220.00
- 99%
- Career Henan Chemical Co
