ChemicalBook >> CAS DataBase List >>N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoroMethyl)phenyl]squaraMide

N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoroMethyl)phenyl]squaraMide

N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoroMethyl)phenyl]squaraMide structure

CAS No.: 1211565-08-0

Chemical Name:: N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoroMethyl)phenyl]squaraMide

Synonyms: Rawal Squaramide Organocatalyst;N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoroMethyl)phenyl]squaraMide;N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N'-[4-(trifluoromethyl)phenyl]squaramide 95%;3-[[(1R,2R)-2-(1-piperidinyl)cyclohexyl]aMino]-4-[[4-(trifluoroMethyl)phenyl]aMino]-3-Cyclobutene-1,2-dione;N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoromethyl)phenyl]squaramide;3-(((1R,2R)-2-(Piperidin-1-yl)cyclohexyl)amino)-4-((4-(trifluoromethyl)phenyl)amino)cyclobut-3-ene-1,2-dione;3-Cyclobutene-1,2-dione, 3-[[(1R,2R)-2-(1-piperidinyl)cyclohexyl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-;3-[[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]amino]-4-[[4- (trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione,99%e.e.;3-[[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione, 98%, (99% ee)

CBNumber:: CB02638504

Molecular Formula:: C22H26F3N3O2

Molecular Weight:: 421.46

MDL Number:: MFCD18827464

MOL File:: 1211565-08-0.mol

MSDS File:: SDS

Last updated:2026-05-27 17:34:24

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N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoroMethyl)phenyl]squaraMide Properties

Melting point	250 °C (decomp)
Boiling point	497.4±55.0 °C(Predicted)
Density	1.31±0.1 g/cm3(Predicted)
storage temp.	2-8°C, protect from light, stored under nitrogen
pka	8.97±0.20(Predicted)
form	powder
Appearance	White to off-white Solid
optical activity	[α]/D -42.0±2.0°, c = 1 in DMSO
InChI	1S/C22H26F3N3O2/c23-22(24,25)14-8-10-15(11-9-14)26-18-19(21(30)20(18)29)27-16-6-2-3-7-17(16)28-12-4-1-5-13-28/h8-11,16-17,26-27H,1-7,12-13H2/t16-,17-/m1/s1
InChIKey	JRSCPJJNZMRAQS-IAGOWNOFSA-N
SMILES	C1(=O)C(NC2=CC=C(C(F)(F)F)C=C2)=C(N[C@@H]2CCCC[C@H]2N2CCCCC2)C1=O
UNSPSC Code	12352005
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS05,GHS07
Signal word	Danger
Hazard statements	H315-H318-H335
Precautionary statements	P280-P302+P352-P305+P351+P338+P310
target organs	Respiratory system
Hazard Codes	C
Risk Statements	37/38-41
Safety Statements	26-39
WGK Germany	3
Storage Class	11 - Combustible Solids
Hazard Classifications	Eye Dam. 1 Skin Irrit. 2 STOT SE 3

N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoroMethyl)phenyl]squaraMide price More Price(11)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	728357	N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoromethyl)phenyl]squaramide 95%	1211565-08-0	100mg	$182	2026-04-30	Buy
Sigma-Aldrich	728357	N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoromethyl)phenyl]squaramide 95%	1211565-08-0	500mg	$511	2026-04-30	Buy
Strem Chemicals	07-1356	3-[[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione, 98%, (99% ee) 98%,(99%ee)	1211565-08-0	50mg	$123	2026-04-30	Buy
Synthonix	P62907	3-[[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione >98%	1211565-08-0	100mg	$80	2026-05-06	Buy
aablocks	AA009ZUM	3-[[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione 97%	1211565-08-0	50mg	$48	2026-05-28	Buy

Product number	Packaging	Price	Buy
728357	100mg	$182	Buy
728357	500mg	$511	Buy
07-1356	50mg	$123	Buy
P62907	100mg	$80	Buy
AA009ZUM	50mg	$48	Buy

N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoroMethyl)phenyl]squaraMide Chemical Properties, Uses, Production

Uses

It can act as a catalyst for the asymmetric tandem aza-Michael addition-protonation between 1-nitro cyclohexene and 4-methoxyaniline to form the corresponding α-arylamino-β-nitro cyclohexane in a 35:65 trans/cis mixture.

N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoroMethyl)phenyl]squaraMide Preparation Products And Raw materials

Raw materials

Preparation Products

N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoroMethyl)phenyl]squaraMide Suppliers

Global Suppliers ( 27)

Supplier	Tel	Email	Country	ProdList	Advantage
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
Daicel Chiral Technologies (China)CO.,LTD	021-50460086-9 15921403865	han_yajun@dctc.daicel.com	China	7909	65
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51389	80
Shanghai Chiral bio-compound co., Ltd.	021-5068 3667/17749785980/1029026415; 17749785980	1029026415@qq.com	China	4501	58
Shanghai YuanYe Biotechnology Co., Ltd.	15026964105	2881489226@qq.com	China	89667	60
Greenherbs Science and Technology Development Co., Ltd.	010-61136123	pub02@greenherbs.com.cn	China	4045	58
Aikon International Limited	025-58851090 13913916777	sales01@aikonchem.com	China	15947	58
Shanghai Anyinuo Biomedical Technology Co., Ltd.	021-34625901	420970979@qq.com	China	5978	58
Career Henan Chemica Co	+86-0371-86658258 +86-13203830695	laboratory@coreychem.com	China	30203	58
Yangzhou modier Electronic Materials Co., Ltd	13761402923 19975033992	market@modeltemol.com	China	7840	58

Supplier	Advantage
Adamas Reagent, Ltd.	59
Daicel Chiral Technologies (China)CO.,LTD	65
Sigma-Aldrich	80
Shanghai Chiral bio-compound co., Ltd.	58
Shanghai YuanYe Biotechnology Co., Ltd.	60
Greenherbs Science and Technology Development Co., Ltd.	58
Aikon International Limited	58
Shanghai Anyinuo Biomedical Technology Co., Ltd.	58
Career Henan Chemica Co	58
Yangzhou modier Electronic Materials Co., Ltd	58

N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoroMethyl)phenyl]squaraMide Spectrum

N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoroMethyl)phenyl]squaraMide(1211565-08-0)¹HNMR

1211565-08-0 (N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoroMethyl)phenyl]squaraMide) Related Search:

3-[[3,5-bis(trifluoroMethyl)phenyl]aMino]-4-[[(1R,2R)-2-(1-piperidinyl)cyclohexyl]aMino]-3-Cyclobutene-1,2-dione 3-[[(9R)-6'-Methoxycinchonan-9-yl]aMino]-4-[[4-(trifluoroMethyl)phenyl]aMino]-3-Cyclobutene-1,2-dione 3-[[(1S,2S)-2-(1-piperidinyl)cyclohexyl]aMino]-4-[[4-(trifluoroMethyl)phenyl]aMino]-3-Cyclobutene-1,2-dione 3-[[(1S,2S)-2-aMinocyclohexyl]aMino]-4-[[3,5-bis(trifluoroMethyl)phenyl]aMino]-3-Cyclobutene-1,2-dione 3-[[(8α,9S)-6'-Methoxycinchonan-9-yl]aMino]-4-[[4-(trifluoroMethyl)phenyl]aMino]-3-Cyclobutene-1,2-dione

3-[[3,5-bis(trifluoroMethyl)phenyl]aMino]-4-[[(1S,2S)-2-(1-pyrrolidinyl)cyclohexyl]aMino]-

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N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoroMethyl)phenyl]squaraMide 3-[[(1R,2R)-2-(1-piperidinyl)cyclohexyl]aMino]-4-[[4-(trifluoroMethyl)phenyl]aMino]-3-Cyclobutene-1,2-dione Rawal Squaramide Organocatalyst N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N'-[4-(trifluoromethyl)phenyl]squaramide 95% 3-[[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]amino]-4-[[4- (trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione,99%e.e. 3-[[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione, 98%, (99% ee) 3-Cyclobutene-1,2-dione, 3-[[(1R,2R)-2-(1-piperidinyl)cyclohexyl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]- 3-(((1R,2R)-2-(Piperidin-1-yl)cyclohexyl)amino)-4-((4-(trifluoromethyl)phenyl)amino)cyclobut-3-ene-1,2-dione N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoromethyl)phenyl]squaramide 1211565-08-0