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ChemicalBook >> CAS DataBase List >>1-Cyclopentyl-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-6-(4-(MorpholinoMethyl)phenyl)-1H-indazole-4-carboxaMide

1-Cyclopentyl-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-6-(4-(MorpholinoMethyl)phenyl)-1H-indazole-4-carboxaMide

1-Cyclopentyl-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-6-(4-(MorpholinoMethyl)phenyl)-1H-indazole-4-carboxaMide Structure
1-Cyclopentyl-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-6-(4-(MorpholinoMethyl)phenyl)-1H-indazole-4-carboxaMide structure
CAS No.
1396772-26-1
Chemical Name:
1-Cyclopentyl-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-6-(4-(MorpholinoMethyl)phenyl)-1H-indazole-4-carboxaMide
Synonyms
CS-724;EPZ 00568;EPZ005687;EPZ005687 ，S7004;EPZ-005687;EPZ 00568;EPZ005687;EPZ-005687;EPZ005687, 10 mM in DMSO;1-Cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(morpholinomethyl)ph;1-CYCLOPENTYL-N-((4,6-DIMETHYL-2-OXO-1,2-DIHYDROPYRIDIN-3-YL)METHYL)-6-(4-(MORPHOLINOMETHYL)PHENYL)-;1-cyclopentyl-n-[(4,6-dimethyl-2-oxo-1h-pyridin-3-yl)methyl]-6-[4-(morpholin-4-ylmethyl)phenyl]indazole-4-carboxamide
CBNumber:
CB02645672
Molecular Formula:
C32H37N5O3
Molecular Weight:
539.67
MDL Number:
MFCD25372029
MOL File:
1396772-26-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-03 11:24:09
Request For Quotation

1-Cyclopentyl-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-6-(4-(MorpholinoMethyl)phenyl)-1H-indazole-4-carboxaMide Properties

Boiling point 797.9±60.0 °C(Predicted)
Density 1.31±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility insoluble in EtOH; insoluble in H2O; ≥3.86 mg/mL in DMSO
form solid
pka 11.88±0.10(Predicted)
color Off-white to yellow
FDA UNII GQ4LD5KG1E

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

1-Cyclopentyl-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-6-(4-(MorpholinoMethyl)phenyl)-1H-indazole-4-carboxaMide price More Price(40)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 13966 EPZ005687 ≥98% 1396772-26-1 5mg $95 2026-04-30 Buy
Cayman Chemical 13966 EPZ005687 ≥98% 1396772-26-1 10mg $168 2026-04-30 Buy
Cayman Chemical 13966 EPZ005687 ≥98% 1396772-26-1 25mg $370 2026-04-30 Buy
Cayman Chemical 13966 EPZ005687 ≥98% 1396772-26-1 50mg $647 2026-04-30 Buy
ChemScene CS-1215 EPZ005687 99.46% 1396772-26-1 5mg $71 2026-06-04 Buy
Product number Packaging Price Buy
13966 5mg $95 Buy
13966 10mg $168 Buy
13966 25mg $370 Buy
13966 50mg $647 Buy
CS-1215 5mg $71 Buy

1-Cyclopentyl-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-6-(4-(MorpholinoMethyl)phenyl)-1H-indazole-4-carboxaMide Chemical Properties,Uses,Production

Uses

EPZ005687 is a potent, selective inhibitor of the lysine methyltranferase EZH2 (Ki = 24 nM), the enzymatic subunit of polycomb repressive complex 2 (PRC2). It acts competitively with the EZH2 substrate S-adenosylmethionine. EPZ005687 has greater than 500-fold selectivity against 15 other protein methyltransferases and has 50-fold selectivity against EZH1. It blocks trimethylation of the PRC2 target histone 3 lysine 27 (IC50 = 80 nM), decreasing the proliferation of lymphoma cells carrying mutant, but not wild-type, EZH2.[Cayman Chemical]

Uses

EPZ005687 is a potent and selective inhibitor of EZH2.

Definition

ChEBI: 1-cyclopentyl-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-6-[4-(4-morpholinylmethyl)phenyl]-4-indazolecarboxamide is a member of indazoles.

Biological Activity

epz005687 is a potent inhibitor of ezh2, an enzymatic subunit of polycomb repressive complex 2 (prc2) catalyzing the methylation of histone h3 lysine 27 (h3k27), that inhibits ezh2 with a value of inhibition constant ki of 24 nm, which is 500-fold and 50-fold greater in selectivity than 15 other protein methyltransferases and closely related ezh1 respectively. epz005687 concentration-dependently inhibits the enzymatic activity of prc2 with a value of 50% inhibition concentration ic50 of 54 nm through binding to the s-adenosylmethionine (sam) pocket of the ezh2 set domain. study results have shown that epz005687 reduces h3k27 methylation in a variety of lymphoma cells and induces apoptotic cell killing in heterozygous tyr641 or ala677 mutant cells.knutson sk, wigle tj, warholic nm, sneeringer cj, allain cj, klaus cr, sacks jd, raimondi a, majer cr, song j, scott mp, jin l, smith jj, olhava ej, chesworth r, moyer mp, richon vm, copeland ra, keilhack h, pollock rm, kuntz kw. a selective inhibitor of ezh2 blocks h3k27 methylation and kills mutant lymphoma cells. nat chem biol. 2012 nov;8(11):890-6.

target

EZH2

IC 50

EZH2: 24 nM (Ki)

1-Cyclopentyl-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-6-(4-(MorpholinoMethyl)phenyl)-1H-indazole-4-carboxaMide Preparation Products And Raw materials

Raw materials

Preparation Products

1-Cyclopentyl-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-6-(4-(MorpholinoMethyl)phenyl)-1H-indazole-4-carboxaMide Suppliers

Global( 137)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2915 55
Jinan Trio PharmaTech Co., Ltd. 0531-88811783 sales@trio-pharmatech.com China 1856 62
Dalian Meilun Biotech Co., Ltd. 0411-62910999 13889544652 sales@meilune.com China 4765 58
Chengdu NoVi Biotechnology Co., Ltd. 028-81458053 novibiotech@163.com sales@novi-biotech.com China 226 55
NCE Biomedical Co.,Ltd. 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 China 1490 55
Shanghai Jian Chao Chemical Technology Co., Ltd. 150-2103-5486 18017383231 983544897@qq.com China 9336 55
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7545 61
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29985 65
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4853 58
AdooQ BioScience, LLC +1 (866) 930-6790 info@adooq.com United States 2774 58
Supplier Advantage
Shanghai Boyle Chemical Co., Ltd. 55
Jinan Trio PharmaTech Co., Ltd. 62
Dalian Meilun Biotech Co., Ltd. 58
Chengdu NoVi Biotechnology Co., Ltd. 55
NCE Biomedical Co.,Ltd. 55
Shanghai Jian Chao Chemical Technology Co., Ltd. 55
Haoyuan Chemexpress Co., Ltd. 61
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65
MedChemexpress LLC 58
AdooQ BioScience, LLC 58

View Lastest Price from 1-Cyclopentyl-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-6-(4-(MorpholinoMethyl)phenyl)-1H-indazole-4-carboxaMide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
EPZ005687 pictures 2026-06-02 EPZ005687
1396772-26-1
 $53.00-138.00 99.66% 10g TargetMol Chemicals Inc.
1-Cyclopentyl-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-6-(4-(MorpholinoMethyl)phenyl)-1H-indazole-4-carboxaMide pictures 2019-09-02 1-Cyclopentyl-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-6-(4-(MorpholinoMethyl)phenyl)-1H-indazole-4-carboxaMide
1396772-26-1
 $1.00 1KG 98% 1lg; 2kg; 5kg; 10kg; 100kg Career Henan Chemical Co
  • EPZ005687 pictures
  • EPZ005687
    1396772-26-1
  • $53.00-138.00
  • 99.66%
  • TargetMol Chemicals Inc.

1-Cyclopentyl-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-6-(4-(MorpholinoMethyl)phenyl)-1H-indazole-4-carboxaMide Spectrum

1-Cyclopentyl-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-6-(4-(MorpholinoMethyl)phenyl)-1H-indazole-4-carboxaMide(1396772-26-1)1HNMR

1396772-26-1(1-Cyclopentyl-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-6-(4-(MorpholinoMethyl)phenyl)-1H-indazole-4-carboxaMide)Related Search:

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EPZ005687;EPZ-005687 1-Cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(morpholinomethyl)ph 1-Cyclopentyl-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-6-(4-(MorpholinoMethyl)phenyl)-1H-indazole-4-carboxaMide EPZ005687 1H-Indazole-4-carboxamide, 1-cyclopentyl-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-6-[4-(4-morpholinylmethyl)phenyl]- 1-Cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(morpholinomethyl)phenyl)-1H-indazole-4-carboxamide EPZ 005687 EPZ 005687 1-Cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(morpholinomethyl)phenyl)-1H-indazole-4-carboxamide EPZ 00568 EPZ-005687;EPZ 00568 CS-724 1-CYCLOPENTYL-N-((4,6-DIMETHYL-2-OXO-1,2-DIHYDROPYRIDIN-3-YL)METHYL)-6-(4-(MORPHOLINOMETHYL)PHENYL)- 1-cyclopentyl-n-[(4,6-dimethyl-2-oxo-1h-pyridin-3-yl)methyl]-6-[4-(morpholin-4-ylmethyl)phenyl]indazole-4-carboxamide 1-Cyclopentyl-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-6-(4-(MorpholinoMethyl)phenyl)-1H-indazole-4-carboxaMide USP/EP/BP EPZ005687, 10 mM in DMSO EPZ005687 ，S7004 1396772-26-1 139772-26-1 C32H37N5O3 Inhibitors API