ETHYL 2-BROMO-4-(TRIFLUOROMETHYL)OXAZOLE-5-CARBOXYLATE
- CAS No.
- 1227934-69-1
- Chemical Name:
- ETHYL 2-BROMO-4-(TRIFLUOROMETHYL)OXAZOLE-5-CARBOXYLATE
- Synonyms
- Ethyl 2-bromo-4-(trifluoromethyl)oxazole-5-carboxylat;ETHYL 2-BROMO-4-(TRIFLUOROMETHYL)OXAZOLE-5-CARBOXYLATE;ETHYL 2-BROMO-4-(TRIFLUOROMETHYL)-1,3-OXAZOLE-5-CARBOXYLATE;5-Oxazolecarboxylic acid, 2-bromo-4-(trifluoromethyl)-, ethyl ester
- CBNumber:
- CB02646932
- Molecular Formula:
- C7H5BrF3NO3
- Molecular Weight:
- 288.02
- MDL Number:
- MFCD17926293
- MOL File:
- 1227934-69-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Ethyl2-Bromo-4-(trifluoromethyl)oxazole-5-carboxylate | E938228 | 10mg | $45 |
| Ethyl2-bromo-4-(trifluoromethyl)oxazole-5-carboxylate | 9360BB | 250mg | $281 |
| Ethyl2-bromo-4-(trifluoromethyl)oxazole-5-carboxylate | 9360BB | 1g | $616 |
| ethyl2-bromo-4-(trifluoromethyl)oxazole-5-carboxylate 95%-98% | 10-2548 | 1g | $764 |
| Ethyl2-bromo-4-(trifluoromethyl)oxazole-5-carboxylate 95% | CM248363 | 5g | $1449 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
ETHYL 2-BROMO-4-(TRIFLUOROMETHYL)OXAZOLE-5-CARBOXYLATE price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | E938228 | Ethyl2-Bromo-4-(trifluoromethyl)oxazole-5-carboxylate | 1227934-69-1 | 10mg | $45 | 2021-12-16 | Buy |
| AK Scientific | 9360BB | Ethyl2-bromo-4-(trifluoromethyl)oxazole-5-carboxylate | 1227934-69-1 | 250mg | $281 | 2021-12-16 | Buy |
| AK Scientific | 9360BB | Ethyl2-bromo-4-(trifluoromethyl)oxazole-5-carboxylate | 1227934-69-1 | 1g | $616 | 2021-12-16 | Buy |
| Abosyn | 10-2548 | ethyl2-bromo-4-(trifluoromethyl)oxazole-5-carboxylate 95%-98% | 1227934-69-1 | 1g | $764 | 2021-12-16 | Buy |
| Chemenu | CM248363 | Ethyl2-bromo-4-(trifluoromethyl)oxazole-5-carboxylate 95% | 1227934-69-1 | 5g | $1449 | 2021-12-16 | Buy |
ETHYL 2-BROMO-4-(TRIFLUOROMETHYL)OXAZOLE-5-CARBOXYLATE Chemical Properties,Uses,Production
Synthesis
135026-17-4
1227934-69-1
Step 2: Ethyl 2-amino-4-(trifluoromethyl)oxazole-5-carboxylate (A-1) (9.8 g) was suspended in acetonitrile (100 mL), and copper (II) bromide (11.8 g) and tert-butylnitrite (13.8 mL) were slowly added sequentially at 0 °C. The reaction mixture was slowly warmed from 0 °C to room temperature under nitrogen protection and stirred at this temperature for 4 hours. Upon completion of the reaction, the mixture was concentrated. The concentrated residue was suspended in EtOAc (200 mL), washed sequentially with 1N HCl (3 x 100 mL) and brine (1 x 100 mL), and the organic phase was dried over Na2SO4, filtered and concentrated. The crude product was purified by fast column chromatography (eluent: EtOAc/hexane) to afford ethyl 2-bromo-4-trifluoromethyl oxazole-5-carboxylate (A-2) as a colorless liquid (9.18 g, 73% yield).LCMS (ESI) [M + 1]+ 288.2.
References
[1] Patent: WO2010/59606, 2010, A2. Location in patent: Page/Page column 159
[2] Patent: WO2018/11628, 2018, A1. Location in patent: Paragraph 00321
[3] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 23, p. 6410 - 6414
ETHYL 2-BROMO-4-(TRIFLUOROMETHYL)OXAZOLE-5-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
ETHYL 2-BROMO-4-(TRIFLUOROMETHYL)OXAZOLE-5-CARBOXYLATE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhou Victorypharm Co.,Ltd. | +86-13916956214 | sales@victory-pharm.com | China | 1299 | 58 |
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| Aikon International Limited | 025-66113011 13155353615 | qzhang@aikonchem.com | China | 15394 | 58 |
| Shanghai Jizhi Biochemical Technology Co. Ltd. | 4009004166/18616739031 18616739031 | 3007523370@qq.com | China | 52693 | 58 |
| Chengdu Feibai Pharmaceutical Co., Ltd. | 028-84641798 18782128315 | 3302391190@qq.com | China | 9760 | 55 |
| Ningbo Benkang jishi Pharmaceutical Technology Co., Ltd. | 15990591583 | China | 6086 | 58 |
