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Ethyl 2-bromo-4-(trifluoromethyl)oxazole-5-carboxylate

Ethyl 2-bromo-4-(trifluoromethyl)oxazole-5-carboxylate Structure
Ethyl 2-bromo-4-(trifluoromethyl)oxazole-5-carboxylate structure
CAS No.
1227934-69-1
Chemical Name:
Ethyl 2-bromo-4-(trifluoromethyl)oxazole-5-carboxylate
Synonyms
Ethyl 2-bromo-4-(trifluoromethyl)oxazole-5-carboxylat;Ethyl 2-bromo-4-(trifluoromethyl)oxazole-5-carboxylate;ETHYL 2-BROMO-4-(TRIFLUOROMETHYL)-1,3-OXAZOLE-5-CARBOXYLATE;5-Oxazolecarboxylic acid, 2-bromo-4-(trifluoromethyl)-, ethyl ester
CBNumber:
CB02646932
Molecular Formula:
C7H5BrF3NO3
Molecular Weight:
288.02
MDL Number:
MFCD17926293
MOL File:
1227934-69-1.mol
MSDS File:
SDS
Last updated:2026-09-12 18:48:01
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Ethyl 2-bromo-4-(trifluoromethyl)oxazole-5-carboxylate Properties

Boiling point 297.5±50.0 °C(Predicted)
Density 1.698±0.06 g/cm3(Predicted)
pka -6.06±0.10(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338

Ethyl 2-bromo-4-(trifluoromethyl)oxazole-5-carboxylate price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
AstaTech 50680 ETHYL 2-BROMO-4-(TRIFLUOROMETHYL)OXAZOLE-5-CARBOXYLATE 97% 1227934-69-1 50MG $96 2026-04-30 Buy
AstaTech 50680 ETHYL 2-BROMO-4-(TRIFLUOROMETHYL)OXAZOLE-5-CARBOXYLATE 97% 1227934-69-1 0.25G $220 2026-04-30 Buy
AstaTech 50680 ETHYL 2-BROMO-4-(TRIFLUOROMETHYL)OXAZOLE-5-CARBOXYLATE 97% 1227934-69-1 1G $481 2026-04-30 Buy
Biosynth CZB93469 Ethyl 2-bromo-4-(trifluoromethyl)oxazole-5-carboxylate 1227934-69-1 100mg $380 2026-06-04 Buy
Biosynth CZB93469 Ethyl 2-bromo-4-(trifluoromethyl)oxazole-5-carboxylate 1227934-69-1 1g $991.2 2026-06-04 Buy
Product number Packaging Price Buy
50680 50MG $96 Buy
50680 0.25G $220 Buy
50680 1G $481 Buy
CZB93469 100mg $380 Buy
CZB93469 1g $991.2 Buy

Ethyl 2-bromo-4-(trifluoromethyl)oxazole-5-carboxylate Chemical Properties,Uses,Production

Synthesis

2-AMINO-4-TRIFLUOROMETHYL-OXAZOLE-5-CARBOXYLIC ACID ETHYL ESTER

135026-17-4

ETHYL 2-BROMO-4-(TRIFLUOROMETHYL)OXAZOLE-5-CARBOXYLATE

1227934-69-1

Step 2: Ethyl 2-amino-4-(trifluoromethyl)oxazole-5-carboxylate (A-1) (9.8 g) was suspended in acetonitrile (100 mL), and copper (II) bromide (11.8 g) and tert-butylnitrite (13.8 mL) were slowly added sequentially at 0 °C. The reaction mixture was slowly warmed from 0 °C to room temperature under nitrogen protection and stirred at this temperature for 4 hours. Upon completion of the reaction, the mixture was concentrated. The concentrated residue was suspended in EtOAc (200 mL), washed sequentially with 1N HCl (3 x 100 mL) and brine (1 x 100 mL), and the organic phase was dried over Na2SO4, filtered and concentrated. The crude product was purified by fast column chromatography (eluent: EtOAc/hexane) to afford ethyl 2-bromo-4-trifluoromethyl oxazole-5-carboxylate (A-2) as a colorless liquid (9.18 g, 73% yield).LCMS (ESI) [M + 1]+ 288.2.

References

[1] Patent: WO2010/59606, 2010, A2. Location in patent: Page/Page column 159
[2] Patent: WO2018/11628, 2018, A1. Location in patent: Paragraph 00321
[3] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 23, p. 6410 - 6414

Ethyl 2-bromo-4-(trifluoromethyl)oxazole-5-carboxylate Preparation Products And Raw materials

Raw materials

2-Amino-4-trifluoromethyl-oxazole-5-carboxylic acid ethyl ester tert-Butyl nitrite Cupric bromide Acetonitrile

Preparation Products

Ethyl 2-bromo-4-(trifluoromethyl)oxazole-5-carboxylate Suppliers

Global( 19)Suppliers
Supplier Tel Email Country ProdList Advantage
Nantong Bosu Pharmaceutical Technology Co., Ltd. 0513-51005092; 15962844273 tashiyxy@163.com China 915 58
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Cochemical Ltd. 029-86115547 17791676824 sales@cochemical.com China 6736 58
Aikon International Limited 025-66113011 19370895928 qzhang@aikonchem.com China 15390 58
Suzhou Victorypharm Co.,Ltd. +86-13916956214 sales@victory-pharm.com China 1298 58
Ningbo Benkang jishi Pharmaceutical Technology Co., Ltd. 15990591583 China 6129 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 59929 58
Suzhou Victorypharm Co.,Ltd. 512-68242903 13916956214 sales@victory-pharm.com China 1523 58
Bejing Famous Pharmaceutical Technology Co., Ltd. 15811073878 2559355526@qq.com China 10680 58
Zhengzhou Converging Chemical Co. LTD 0371-53399770 18037166334 3857571523@qq.com China 7099 58
Supplier Advantage
Nantong Bosu Pharmaceutical Technology Co., Ltd. 58
Amadis Chemical Company Limited 58
Cochemical Ltd. 58
Aikon International Limited 58
Suzhou Victorypharm Co.,Ltd. 58
Ningbo Benkang jishi Pharmaceutical Technology Co., Ltd. 58
Bide Pharmatech Ltd. 58
Suzhou Victorypharm Co.,Ltd. 58
Bejing Famous Pharmaceutical Technology Co., Ltd. 58
Zhengzhou Converging Chemical Co. LTD 58

1227934-69-1(Ethyl 2-bromo-4-(trifluoromethyl)oxazole-5-carboxylate)Related Search:

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Ethyl 2-amino-5-fluoronicotinate 2-Chloro-5-methylpyridine-4-carboxylic acid ethyl ester

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Ethyl 2-bromo-4-(trifluoromethyl)oxazole-5-carboxylat ETHYL 2-BROMO-4-(TRIFLUOROMETHYL)-1,3-OXAZOLE-5-CARBOXYLATE 5-Oxazolecarboxylic acid, 2-bromo-4-(trifluoromethyl)-, ethyl ester Ethyl 2-bromo-4-(trifluoromethyl)oxazole-5-carboxylate 1227934-69-1 C7H5BrF3NO3