PIPERAZINE DIHYDROCHLORIDE
- CAS No.
- 142-64-3
- Chemical Name:
- PIPERAZINE DIHYDROCHLORIDE
- Synonyms
- PipDCl;dowzenedhc;Piperazine 2HCl;dihydropipwormer;PIPERAZINE DI HCL;piperazinewormerpremix;Piperazine hydrate CRS;piperazinehydrochloride;Piperazinium Dichloride;PIPERAZINE DIHYDROCHLORIDE
- CBNumber:
- CB0264741
- Molecular Formula:
- C4H12Cl2N2
- Molecular Weight:
- 159.06
- MDL Number:
- MFCD00012754
- MOL File:
- 142-64-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Piperazine Dihydrochloride Monohydrate >98.0%(N) | P0450 | 25g | $30 |
| Piperazine Dihydrochloride Monohydrate >98.0%(N) | P0450 | 500g | $146 |
| Piperazine dihydrochloride monohydrate ≥98% | 43353 | 25G | $20.2 |
| Piperazine dihydrochloride monohydrate ≥98% | 43353 | 100G | $35.9 |
| Piperazine dihydrochloride monohydrate ≥98% | 43353 | 250G | $71.8 |
| More product size | |||
| Melting point | 320°C(dec.)(lit.) |
|---|---|
| Boiling point | 262.01°C (rough estimate) |
| Density | 1.3011 (rough estimate) |
| refractive index | 1.6300 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Water |
| form | White crystalline solid |
| color | White to Off-White |
| Major Application | pharmaceutical (small molecule) |
| InChI | InChI=1S/C4H10N2.2ClH/c1-2-6-4-3-5-1;;/h5-6H,1-4H2;2*1H |
| InChIKey | CVVIJWRCGSYCMB-UHFFFAOYSA-N |
| SMILES | C1NCCNC1.Cl.Cl |
| LogP | -1.171 (est) |
| CAS DataBase Reference | 142-64-3(CAS DataBase Reference) |
| Substances Added to Food (formerly EAFUS) | PIPERAZINE DIHYDROCHLORIDE |
| FDA UNII | 17VU4Z4W88 |
| EPA Substance Registry System | Piperazine dihydrochloride (142-64-3) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H319-H334-H361fd-H412 | |||||||||
| Precautionary statements | P202-P261-P273-P302+P352-P305+P351+P338-P308+P313 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 36/37/38-42/43 | |||||||||
| Safety Statements | 22-26-36/37 | |||||||||
| OEB | B | |||||||||
| OEL | TWA: 5 mg/m3 | |||||||||
| WGK Germany | WGK 2 | |||||||||
| RTECS | TL4025000 | |||||||||
| F | 3-10 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 2933599550 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Aquatic Chronic 3 Eye Irrit. 2 Repr. 2 Resp. Sens. 1 Skin Irrit. 2 Skin Sens. 1 |
|||||||||
| Hazardous Substances Data | 142-64-3(Hazardous Substances Data) | |||||||||
| Toxicity | mouse,LD50,intraperitoneal,1970mg/kg (1970mg/kg),LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION,Japanese Journal of Pharmacology. Vol. 17, Pg. 475, 1967. | |||||||||
| NFPA 704 |
|
PIPERAZINE DIHYDROCHLORIDE price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | P0450 | Piperazine Dihydrochloride Monohydrate >98.0%(N) | 142-64-3 | 25g | $30 | 2026-04-30 | Buy |
| TCI Chemical | P0450 | Piperazine Dihydrochloride Monohydrate >98.0%(N) | 142-64-3 | 500g | $146 | 2026-04-30 | Buy |
| Chem-Impex | 43353 | Piperazine dihydrochloride monohydrate ≥98% | 142-64-3 | 25G | $20.2 | 2026-05-19 | Buy |
| Chem-Impex | 43353 | Piperazine dihydrochloride monohydrate ≥98% | 142-64-3 | 100G | $35.9 | 2026-05-19 | Buy |
| Chem-Impex | 43353 | Piperazine dihydrochloride monohydrate ≥98% | 142-64-3 | 250G | $71.8 | 2026-05-19 | Buy |
PIPERAZINE DIHYDROCHLORIDE Chemical Properties,Uses,Production
Uses
It is used as a one day wormer, either in water or feed, for the control of Round worms in poultry, swine, and horses. It also controls nodular worms in swine, and small strongyles in horses.
Uses
In the manufacture of fibers, pharmarceuticals, and insecticides.
Uses
Piperazine Dihydrochloride is an anthelmintic agent used in the treatment of parasitic worms in animals.
General Description
White to cream-colored needles or powder. Mp: 318-20°C (with decomposition).
Reactivity Profile
PIPERAZINE DIHYDROCHLORIDE is incompatible with the following: Water, HEAT, flames, oxidizers. PIPERAZINE DIHYDROCHLORIDE absorbs moisture from air. PIPERAZINE DIHYDROCHLORIDE may create flammable condition upon contact with HEAT, FLAMES and OXIDIZERS.
Safety Profile
Moderately toxic by intraperitoneal route. Mildly toxic by ingestion. When heated to decomposition it emits very toxic fumes of NOx and HCl. Used in making fiber, pharmaceuticals, and insecticides. See also PIPERAZINE.
Synthesis
Piperazine dihydrochloride was obtained by adding concentrated hydrochloric acid to an ethanolic solution of anhydrous piperazine: To an ethanolic solution of anhydrous piperazine (1 eq.) was slowly added concentrated hydrochloric acid (2 eq.) dropwise to an ethanolic solution of anhydrous piperazine (1 eq.) in an ice bath, a solid was precipitated, and piperazine dihydrochloride was obtained by filtration in a quantitative yield.
Potential Exposure
Agricultural chemical, Suspected reprotoxic hazard. Piperazine is used to manufacture anthelmintics, antifilarials, antihistamines, and tranquilizers; the dihydrochloride is used in the manufacture of fibers, pharmaceuticals and insecticides. They are used as an intermediate in the manufacture of, pesticides, rubber chemicals and fibers. Also, piperazine is widely available, effective, and safe when used on an occasional basis against ascaride infections. It is also considerably cheaper than other anthelminthic drugs. In some countries where ascariasis is not endemic and where piperazine was used predominantly for the treatment of pinworn, it has been withdrawn from use on the grounds that other effective drugs are now available. Clinical dosages occasionally induce transient neurological signs and, in some circumstances, the drug may generate small amounts of nitrosamine in the stomach, which at considerably greater dosage in experimental animals has been demonstrated to have a carcinogenic potential.
Carcinogenicity
Piperazine dihydrochloride is an irritant and sensitizer. Little information exists on the toxicology of piperazine dihydrochloride in humans or in animals. Acute human exposures to the dust have reportedly resulted in irritation to the eyes, mild to moderate skin burns, and sensitization. Exposure levels and duration were not available.
Purification Methods
Crystallise the salt from aqueous EtOH and dry it at 110o. [Beilstein 23 III/IV 17, 23/1 V 30.]
Incompatibilities
Aqueous solution is a strong base. Violent reaction with strong oxidizers and dicyanofurazan. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, nitrogen compounds, carbon tetrachloride. Attacks aluminum, copper, nickel, magnesium and zinc.
PIPERAZINE DIHYDROCHLORIDE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20124 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29794 | 58 |
| Chemsigma International Co., Ltd. | +86-2558742998 +86-19951791336 | info@chemsigma.com | China | 1806 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 18895 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15082 | 58 |
| Alfa Chemistry | info@alfa-chemistry.com | United States | 2344 | 58 | |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52705 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12373 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
View Lastest Price from PIPERAZINE DIHYDROCHLORIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-01 | Piperazine (dihydrochloride)
142-64-3
|
US $0.00-0.00 / KG | 1KG | 98% | 10000kg | Shaanxi Dideu New Materials Co. Ltd | |
 |
2025-11-18 | PIPERAZINE DIHYDROCHLORIDE
142-64-3
|
US $1.10 / g | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2025-09-25 | PIPERAZINE DIHYDROCHLORIDE
142-64-3
|
US $50.00-1.00 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd |
-
- Piperazine (dihydrochloride)
142-64-3
- US $0.00-0.00 / KG
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- PIPERAZINE DIHYDROCHLORIDE
142-64-3
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
-
- PIPERAZINE DIHYDROCHLORIDE
142-64-3
- US $50.00-1.00 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
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