(S)-3-(2-aMino-3-MethylbutanaMido)propane-1-sulfonic acid
- CAS No.
- 1034190-08-3
- Chemical Name:
- (S)-3-(2-aMino-3-MethylbutanaMido)propane-1-sulfonic acid
- Synonyms
- ALZ-801;valiltramiprosate;ALZ-801;ALZ801;ALZ 801;Valiltramiprosate（ALZ-801）;NRZRFNYKMSAZBI-ZETCQYMHSA-N;(S)-3-(2-aMino-3-MethylbutanaMido)propane-1-sulfonic acid;3-[(2S)-2-amino-3-methylbutanamido]propane-1-sulfonic acid;3-[[(2S)-2-Amino-3-methyl-1-oxobutyl]amino]-1-propanesulfonic acid;1-Propanesulfonic acid, 3-[[(2S)-2-amino-3-methyl-1-oxobutyl]amino]-;β-amyloid peptide,Alzheimer,Amyloid-β,ALZ-801,Tramiprosate,disease,inhibit,Abeta,β-amyloid,ALZ801,Valiltramiprosate,Inhibitor,ALZ 801
- CBNumber:
- CB02650993
- Molecular Formula:
- C8H18N2O4S
- Molecular Weight:
- 238.3
- MDL Number:
- MOL File:
- 1034190-08-3.mol
| Density | 1.257±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | Water:250.0(Max Conc. mg/mL);1049.1(Max Conc. mM) |
| pka | 1?+-.0.50(Predicted) |
| form | Solid |
| color | White to off-white |
| Water Solubility | Water : 250 mg/mL (1049.10 mM; Need ultrasonic) |
| FDA UNII | GHG2B47067 |
(S)-3-(2-aMino-3-MethylbutanaMido)propane-1-sulfonic acid Chemical Properties,Uses,Production
Uses
ALZ-801 is a potent and orally available small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor, valine-conjugated proagent of Tramiprosate with substantially improved PK properties and gastrointestinal tolerability compared with the parent compound[1]. ALZ-801 is an advanced and markedly improved candidate for the treatment of alzheimer’s disease[2].
in vivo
ALZ-801 (oral administration; 172?mg/kg; single dose) exhibits mean AUCt values of 58,758 and? 5841 ng/ml.h in plasma and brain, respectively. The ALZ-801: Tramiprosate ratio in plasma and brain is 1.8 and 3.1, respectively in male CD-1 mice[1].
References
[1] John A. Hey, et al. Discovery and Identification of an Endogenous Metabolite of Tramiprosate and Its Prodrug ALZ-801 that Inhibits Beta Amyloid Oligomer Formation in the Human Brain. CNS Drugs. 2018; 32(9): 849–861.
[2] Hey JA, et al. Clinical Pharmacokinetics and Safety of ALZ-801, a Novel Prodrug of Tramiprosate in Development for the Treatment of Alzheimer's Disease. Clin Pharmacokinet. 2018 Mar;57(3):315-333. DOI:10.1007/s40262-017-0608-3
(S)-3-(2-aMino-3-MethylbutanaMido)propane-1-sulfonic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32432 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30229 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39031 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | nickzhang@hangyubiotech.com | China | 10997 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20185 | 58 |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
