MACULOSIN
- CAS No.
- 4549-02-4
- Chemical Name:
- MACULOSIN
- Synonyms
- cyclo(L-Pro-L-Tyr);A-19C;0/4/49;ML-1532II;MACULOSIN;Maculosin TFA;CYCLO(-PRO-TYR);Antibiotic A-19C;Cyclo(L-Tyr-L-Pro-);MACULOSIN USP/EP/BP
- CBNumber:
- CB0265753
- Molecular Formula:
- C14H16N2O3
- Molecular Weight:
- 260.29
- MDL Number:
- MFCD03093467
- MOL File:
- 4549-02-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Maculosin ≥95% | 25019 | 5mg | $143 |
| Maculosin ≥95% | 25019 | 25mg | $458 |
| Maculosin ≥95% | 25019 | 5mg | $130 |
| Maculosin ≥95% | 25019 | 25mg | $416 |
| (3S,8aS)-Hexahydro-3-[(4-hydroxyphenyl)methyl]pyrrolo[1,2-a]pyrazine-1,4-dione | AA0039V6 | 1mg | $52 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H311-H331-H371 | |||||||||
| Precautionary statements | P280-P302+P352-P312-P322-P361-P363-P405-P501-P260-P264-P270-P309+P311-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501-P261-P271-P304+P340-P311-P321-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
MACULOSIN price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 25019 | Maculosin ≥95% | 4549-02-4 | 5mg | $143 | 2026-04-30 | Buy |
| Cayman Chemical | 25019 | Maculosin ≥95% | 4549-02-4 | 25mg | $458 | 2026-04-30 | Buy |
| Cayman Chemical | 25019 | Maculosin ≥95% | 4549-02-4 | 5mg | $130 | 2024-03-01 | Buy |
| Cayman Chemical | 25019 | Maculosin ≥95% | 4549-02-4 | 25mg | $416 | 2024-03-01 | Buy |
| aablocks | AA0039V6 | (3S,8aS)-Hexahydro-3-[(4-hydroxyphenyl)methyl]pyrrolo[1,2-a]pyrazine-1,4-dione | 4549-02-4 | 1mg | $52 | 2026-05-28 | Buy |
MACULOSIN Chemical Properties,Uses,Production
Description
Maculosin is a diketopiperazine metabolite produced by A. alternata, L. capsici, Streptomyces, and the Gram-negative, nonobligate predator bacterial strain 679-2. It acts as a host-specific phytotoxin, inducing formation of weeping necrotic lesions in leaves of spotted knapweed (C. maculosa) when used at a concentration of 10 μM. Maculosin reduces the growth of the plant pathogenic bacteria X. axonopodis and R. solanacearum (MICs = 31.25 μg/ml) as well as the pathogenic oomycetes P. cactorum, P. capsici, P. cinnamomi, P. infestans, and P. ultimum when used at concentrations ranging from 10 to 100 mg/ml. Maculosin also inhibits the growth of M. luteus, M. smegmatis, S. cerevisiae, C. albicans, C. neoformans, and A. niger when used in combination with pyrrolnitrin or banegasin.
Uses
Cyclo(L-Pro-L-Tyr) (maculosin) is a diketopiperazine formed by the fusion of tyrosine and proline, reported as a secondary metabolite of fungi and bacteria. In Pseudomonas aeruginosa, cyclo(L-Pro-L-Tyr) is capable of activating N-acylhomoserine lactones (AHLs). Cyclo(L-Pro-L-Tyr) is also capable of activating or antagonizing other LuxR-based quorum-sensing systems. While the mode of action of cyclo(L-Pro-L-Tyr) is not known, its activity suggests the existence of cross talk among bacterial signalling systems. Cyclo(L-Pro-L-Tyr) was identified as a host-specific toxin produced by Alternaria alternata on spotted knapweed.
Uses
Cyclo(L-prolinyl-L-tyrosine) is a diketopiperazine derivative isolated from Bacillus thuringiensis and Bacillus endophyticus.
Definition
ChEBI: A homodetic cyclic peptide that is a dipeptide composed of L-proline and L-tyrosine joined by peptide linkages.
References
[1] A C STIERLE G A S J H Cardellina. Maculosin, a host-specific phytotoxin for spotted knapweed from Alternaria alternata.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1988: 8008-8011. DOI: 10.1073/pnas.85.21.8008
[2] G. PUOPOLO. Lysobacter capsici AZ78 produces cyclo(l-Pro-l-Tyr), a 2,5-diketopiperazine with toxic activity against sporangia of Phytophthora infestans and Plasmopara viticola[J]. Journal of Applied Microbiology, 2014, 117 4: 1168-1180. DOI: 10.1111/jam.12611
[3] PAKORN WATTANA-AMORN . Antibacterial activity of cyclo(L-Pro-L-Tyr) and cyclo(D-Pro-L-Tyr) from Streptomyces sp. strain 22-4 against phytopathogenic bacteria[J]. Natural Product Research, 2016, 30 17: Pages 1980-1983. DOI: 10.1080/14786419.2015.1095747
[4] CODY C CAIN. Synergistic antimicrobial activity of metabolites produced by a nonobligate bacterial predator.[J]. Antimicrobial Agents and Chemotherapy, 2003, 47 7: 2113-2117. DOI: 10.1128/aac.47.7.2113-2117.2003
MACULOSIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19936 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 18903 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
| Chengdu Youngshe Chemical Co., Ltd. | +8618108235634 | Cecilia@youngshechem.com | China | 2345 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39039 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| LEON (NANJING) BIOTECHNOLOGY CO., LTD. | +8615051830413 | sales.njleonbiotech@gmail.com | China | 5482 | 58 |
| DONBOO AMINO ACID COMPANY | +8618051385538 | donboo@donboo.com | China | 9363 | 58 |
| ForeChem (Nantong) Technology Co.,Ltd. | 513-85982855 18921614129 | sales@xianxingpharm.com | China | 2722 | 61 |
View Lastest Price from MACULOSIN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-18 | cyclo(L-Pro-L-Tyr)
4549-02-4
|
$39.00-155.00 | 99.61% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-12-25 | MACULOSIN
4549-02-4
|
1gram | 99% | 10kg | Zhejiang J&C Biological Technology Co.,Limited |
-
- cyclo(L-Pro-L-Tyr)
4549-02-4
- $39.00-155.00
- 99.61%
- TargetMol Chemicals Inc.
-
- MACULOSIN
4549-02-4
- $0.00
- 99%
- Zhejiang J&C Biological Technology Co.,Limited
