Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-
![Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]- Structure](CAS/20150408/GIF/211555-08-7.gif)
- CAS No.
- 211555-08-7
- Chemical Name:
- Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-
- Synonyms
- Janex 3;WHI-P180, >98%;WHI-P180(Janex 3);WHI-P180, 10 mM in DMSO;WHI P180;JANEX3;WHIP180;JANEX-3;3-(6,7-dimethoxyquinazolin-4-ylamino)phenol;3-[(6,7-Dimethoxy-4-quinazolinyl)amino]phenol;Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-;3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol (Related Reference);WHI-P-180,HER1,Janex3,WHI P180,RET,EGFR,Vascular endothelial growth factor receptor,Inhibitor,Janex-3,WHIP180,inhibit,WHI-P180,VEGFR,ErbB-1,Epidermal growth factor receptor
- CBNumber:
- CB02667258
- Molecular Formula:
- C16H15N3O3
- Molecular Weight:
- 297.31
- MDL Number:
- MFCD02683970
- MOL File:
- 211555-08-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| WHI-P180 A potent inhibitor of lgE-mediated mast cell responses to allergens in vitro and in vivo. | 681500 | 1MG | $200 |
| WHI-P180 ≥98% | 23452 | 500μg | $93 |
| WHI-P180 ≥98% | 23452 | 1mg | $176 |
| WHI-P180 ≥98% | 23452 | 5mg | $684 |
| WHI-P180 99.76% | CS-1702 | 50mg | $1080 |
| More product size | |||
| Boiling point | 476.5±40.0 °C(Predicted) |
|---|---|
| Density | 1.336±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| solubility | DMSO : 25 mg/mL (84.09 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble) |
| form | Powder |
| pka | 9.58±0.10(Predicted) |
| color | White to off-white |
| InChI | 1S/C16H15N3O3/c1-21-14-7-12-13(8-15(14)22-2)17-9-18-16(12)19-10-4-3-5-11(20)6-10/h3-9,20H,1-2H3,(H,17,18,19) |
| InChIKey | BNDYIYYKEIXHNK-UHFFFAOYSA-N |
| SMILES | N(c3cc(ccc3)O)c1ncnc2c1cc(c(c2)OC)OC |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]- price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 681500 | WHI-P180 A potent inhibitor of lgE-mediated mast cell responses to allergens in vitro and in vivo. | 211555-08-7 | 1MG | $200 | 2025-07-31 | Buy |
| Cayman Chemical | 23452 | WHI-P180 ≥98% | 211555-08-7 | 500μg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 23452 | WHI-P180 ≥98% | 211555-08-7 | 1mg | $176 | 2024-03-01 | Buy |
| Cayman Chemical | 23452 | WHI-P180 ≥98% | 211555-08-7 | 5mg | $684 | 2024-03-01 | Buy |
| ChemScene | CS-1702 | WHI-P180 99.76% | 211555-08-7 | 50mg | $1080 | 2021-12-16 | Buy |
Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]- Chemical Properties,Uses,Production
Uses
WHI-P180 (Janex 3) is a multi-kinase inhibitor; inhibits RET, KDR and EGFR with IC50s of 5 nM, 66 nM and 4 μM, respectively.
Biological Activity
WHI-P180 is an inhibitor of multiple kinases with IC50 values of 4.5 nM and 66 nM for RET (c-RET) and KDR, respectively.
in vivo
WHI-P180 is also an active inhibitor of IgE-mediated mast cell responses. The elimination half-life of WHI-P180 in CD-1 mice (BALB/c mice) following iv, ip, or po administration is less than 10 min. Systemic clearance of WHI-P180 is 6742 mL/h/kg in CD-I mice and 8188 mL/h/kg in BALB/c mice. Notably, WHI-P180, when administered in two consecutive nontoxic ip bolus doses of 25 mg/kg, inhibits IgE/antigen-induced vascular hyperpermeability in a well-characterized murine model of passive cutaneous anaphylaxis.
target
| Target | Value |
| RET (Cell-free assay) | 4.5 nM |
| KDR (Cell-free assay) | 66 nM |
IC 50
EGFR: 4 μM (IC50); KDR: 66 nM (IC50); RET: 5 nM (IC50)
References
[1] Newton R, et al. The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity. Eur J Med Chem. 2016 Apr 13;112:20-32. DOI:10.1016/j.ejmech.2016.01.039
[2] Ghosh S, et al. 4-[3-Bromo-4-hydroxyphenyl)amino]-6,7-dimethoxyquinazolin-1-ium chloride methanol solvateand 4-[(3-hydroxyphenyl)amino]-6,7-dimethoxy-1-quinazolinium chloride. Acta Crystallogr C. 2001 Jan;57(Pt 1):76-8. DOI:10.1107/s0108270100013561
[3] Chen CL, et al. Pharmacokinetics and biologic activity of the novel mast cell inhibitor, 4-(3-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline in mice. Pharm Res. 1999 Jan;16(1):117-22. DOI:10.1023/a:1018835232027
Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]- Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29831 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32470 | 58 |
| Henan Alfa Chemical Co., Ltd | +8615838112936 | sale03@alfachem.cn | China | 12761 | 58 |
| Alfa Chemistry | +1-5166625404; | Info@alfa-chemistry.com | United States | 20405 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9984 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 |
View Lastest Price from Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]- manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-02-01 | WHI-P180
211555-08-7
|
US $42.00-136.00 / mg | 99.21% | 10g | TargetMol Chemicals Inc. | ||
![Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]- pictures](https://img.chemicalbook.com/ProductImageEN/2019-9/Small/52a74ed7-749b-4502-bb97-fa685facc639.jpg) |
2019-09-06 | Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-
211555-08-7
|
US $1.00 / KG | 1KG | 98% | 20kg | Career Henan Chemical Co |
-
- WHI-P180
211555-08-7
- US $42.00-136.00 / mg
- 99.21%
- TargetMol Chemicals Inc.
-
- Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-
211555-08-7
- US $1.00 / KG
- 98%
- Career Henan Chemical Co
