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GSK2110183B

GSK2110183B structure

CAS No.: 1047645-82-8

Chemical Name:: GSK2110183B

Synonyms: GSK2110183B;GSK 2110183B;GSK-2110183B;Afuresertib HCl;GSK2110183 hydrochloride;GSK-2110183 hydrochloride;GSK 2110183 hydrochloride;Afuresertib (hydrochloride);Afuresertib HCl (GSK2110183);Afuresertib hydrochloride GSK2110183

CBNumber:: CB02667591

Molecular Formula:: C18H18Cl3FN4OS

Molecular Weight:: 463.78

MDL Number:

MOL File:: 1047645-82-8.mol

Last updated:2025-04-17 18:22:24

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GSK2110183B Properties

storage temp.	Store at -20°C, protect from light, stored under nitrogen
solubility	DMSO:65.0(Max Conc. mg/mL);140.15(Max Conc. mM) DMF:50.0(Max Conc. mg/mL);107.81(Max Conc. mM) Ethanol:50.0(Max Conc. mg/mL);107.81(Max Conc. mM) Ethanol:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.08(Max Conc. mM)
form	A crystalline solid
color	Yellow to brown
FDA UNII	0FC27E442O

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

NFPA 704

	0
2		0

GSK2110183B price More Price(16)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	17988	Afuresertib (hydrochloride) ≥98%	1047645-82-8	1mg	$40	2024-03-01	Buy
Cayman Chemical	17988	Afuresertib (hydrochloride) ≥98%	1047645-82-8	5mg	$138	2024-03-01	Buy
Cayman Chemical	17988	Afuresertib (hydrochloride) ≥98%	1047645-82-8	10mg	$254	2024-03-01	Buy
Cayman Chemical	17988	Afuresertib (hydrochloride)	1047645-82-8	25mg	$583	2024-03-01	Buy
ChemScene	CS-3385	Afuresertib(hydrochloride) 98.02%	1047645-82-8	100mg	$564	2021-12-16	Buy

Product number	Packaging	Price	Buy
17988	1mg	$40	Buy
17988	5mg	$138	Buy
17988	10mg	$254	Buy
17988	25mg	$583	Buy
CS-3385	100mg	$564	Buy

GSK2110183B Chemical Properties,Uses,Production

Uses

Afuresertib is a selective, orally bioavailable inhibitor of Akt1, 2, and 3 with Ki values of 0.08, 2, and 2.6 nM, respectively. It preferentially inhibits the proliferation of human cancer cell lines with Akt pathway activation and various cell lines derived from hematologic malignancies with minimal effect on glucose homeostasis. Afuresertib demonstrates activity against multiple myeloma in both preclinical and clinical models.[Cayman Chemical]

in vivo

Mice bearing BT474 breast tumor xenografts are dosed orally with either vehicle or GSK2110183 at 10, 30 or 100 mg/kg daily for 21 days which result in 8, 37 and 61% TGI, respectively. Mice tolerated GSK2110183 well, with 1-3% body weight loss reported after 5 days of dosing which recover over the course of the study. Other tumor xenograft models which possess an activation of the Akt pathway are explored to further demonstrate compound efficacy. Mice treated with GSK2110183 at 10, 30 and 100 mg/kg result in 23, 37 and 97% TGI, respectively, of SKOV3 xenografts^[2].

IC 50

Akt1: 0.08 nM (Ki); Akt2: 2 nM (Ki); Akt3: 2.6 nM (Ki); Akt1 E17K mutant: 0.2 nM (IC₅₀); PKCη: 210 nM (IC₅₀); PKC-βI: 430 nM (IC₅₀); ROCK: 100 nM (IC₅₀); PKCθ: 510 nM (IC₅₀)

GSK2110183B Preparation Products And Raw materials

Raw materials

Preparation Products

GSK2110183B Suppliers

Global( 88)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38663	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43340	58
Aladdin Scientific		tp@aladdinsci.com	United States	52924	58
Suzhou ARTK Medchem Co., Ltd.	+86-512-68323658 +86-18168183658	sales1@artkmedchem.com	China	39002	58
Shanghai Hanhong Scientific Co., Ltd.	+undefined17612118332	Lucky@hanhonggroup.com	China	6035	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58

Supplier	Advantage
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
TargetMol Chemicals Inc.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
LEAPCHEM CO., LTD.	58
Aladdin Scientific	58
Suzhou ARTK Medchem Co., Ltd.	58
Shanghai Hanhong Scientific Co., Ltd.	58
Amadis Chemical Company Limited	58

Afuresertib (hydrochloride) GSK 2110183B GSK2110183B GSK-2110183B GSK 2110183 hydrochloride GSK2110183 hydrochloride GSK-2110183 hydrochloride N-((S)-1-Amino-3-(3-fluorophenyl)propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)thiophene-2-carboxamide hydrochloride Afuresertib HCl Afuresertib HCl (GSK2110183) Afuresertib HCl salt, GSK-2110183 HCl salt, GSK-2110183B HCl salt N-{(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride 2-Thiophenecarboxamide, n-[(1s)-2-amino-1-[(3-fluorophenyl)methyl]ethyl]-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-, hydrochloride (1:1) AFURESERTIB;GSK 2110183;GSK2110183;GSK 2110183 HYDROCHLORIDE; GSK2110183 HYDROCHLORIDE; GSK-2110183 HYDROCHLORIDE GSK 2110183 hydrochloride - Afuresertib hydrochloride (S)-N-(1-amino-3-(3-fluorophenyl)propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)thiophene-2-carboxamide hydrochloride Afuresertib hydrochloride GSK2110183 Afuresertib,PKC,Protein kinase C,Akt,PKB,Rho-kinase,GSK2110183,ROK,Rho-associated protein kinase,Inhibitor,GSK-2110183,inhibit,Protein kinase B,Afuresertib hydrochloride,Rho-associated kinase,GSK 2110183,ROCK (S)-N-(1-amino-3- (3-fluorophenyl) propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl) thiophene-2-formamide, hydrochloride Afuresertib hydrochloride, 10 mM in DMSO 1047645-82-8 C18H17Cl2FN4OSClH