Henatinib
- CAS No.
- 1239269-51-2
- Chemical Name:
- Henatinib
- Synonyms
- Henatinib;2-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-5-[(2R)-2-hydroxy-3-morpholin-4-ylpropyl]-3-methyl-1,6,7,8-tetrahydropyrrolo[3,2-c]azepin-4-one;Pyrrolo[3,2-c]azepin-4(1H)-one, 2-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-5,6,7,8-tetrahydro-5-[(2R)-2-hydroxy-3-(4-morpholinyl)propyl]-3-methyl-
- CBNumber:
- CB02668619
- Molecular Formula:
- C25H29FN4O4
- Molecular Weight:
- 468.52
- MDL Number:
- MOL File:
- 1239269-51-2.mol
- MSDS File:
- SDS
| Boiling point | 803.5±65.0 °C(Predicted) |
|---|---|
| Density | 1.352±0.06 g/cm3(Predicted) |
| pka | 11.72±0.20(Predicted) |
| FDA UNII | TE20GB753F |
Henatinib Chemical Properties,Uses,Production
Uses
Henatinib is an orally active small-molecule multikinase inhibitor that has demonstrated broad and potent antitumor activities. Henatinib inhibits the activity of VEGFR-2, c-kit, PDGFR with IC50 values of 0.6 nM, 3.3 nM and 41.5 nM, respectively. Henatinib significantly inhibits VEGFR-2 phosphorylation and its downstream signal pathway in human umbilical vein endothelial cells (HUVECs)[1].
IC 50
VEGFR-2: 0.6 nM (IC50); PDGFRα; PDGFRβ
References
[1] Jun Qian, et al. Determination of henatinib in human plasma and urine by liquid chromatography-tandem mass spectrometry and its pharmacokinetic application. J Pharm Biomed Anal. 2013 Jun;80:173-9. DOI:10.1016/j.jpba.2013.03.010
[2] Haitian Quan, et al. Abstract 4259: Preclinical anti-tumor study of henatinib, a novel and selective inhibitor of VEGFR-2 in phase I clinical trials. Cancer Res (2011) 71 (8_Supplement): 4259.
Henatinib Preparation Products And Raw materials
Raw materials
Preparation Products
Henatinib Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| Supplier | Advantage |
|---|---|
| BOC Sciences | 65 |
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
