Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>3-Chloro-4-fluorobenzoic acid

3-Chloro-4-fluorobenzoic acid

3-Chloro-4-fluorobenzoic acid Structure
3-Chloro-4-fluorobenzoic acid structure
CAS No.
403-16-7
Chemical Name:
3-Chloro-4-fluorobenzoic acid
Synonyms
RARECHEM AL BO 0274;TIMTEC-BB SBB003796;1-chloro-3-fluorobezene;4-FLUORO-3-CHLOROBENZOIC ACID;3-CHLORO-4-FLUOROBENZOIC ACID;3-chloro-4-fluorobenzioc acid;3-Chloro-4-fluorobenzoicacid98%;Benzoic acid, 3-chloro-4-fluoro-;3-Chloro-4-fluorobenzoic Acid >3-Chloro-4-fluorobenzoic acid 98%
CBNumber:
CB0267762
Molecular Formula:
C7H4ClFO2
Molecular Weight:
174.56
MDL Number:
MFCD00042477
MOL File:
403-16-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-20 15:44:28
Product description Number Pack Size Price
3-Chloro-4-fluorobenzoic Acid >98.0%(GC)(T) C1275 5g $24
3-Chloro-4-fluorobenzoic Acid >98.0%(GC)(T) C1275 25g $77
3-Chloro-4-fluorobenzoic acid 98% 2621-7-02 1kg $295
3-Chloro-4-fluorobenzoic acid ≥98%(GC) 45374 5G $51.6
3-Chloro-4-fluorobenzoic acid ≥98%(GC) 45374 25G $176.7
More product size
Request For Quotation

3-Chloro-4-fluorobenzoic acid Properties

Melting point 133-135 °C(lit.)
Boiling point 92°C/22mm
Density 1.4016 (estimate)
storage temp. Sealed in dry,Room Temperature
pka 3.77±0.10(Predicted)
form powder to crystal
color White to Light yellow to Light orange
BRN 2574799
InChI InChI=1S/C7H4ClFO2/c8-5-3-4(7(10)11)1-2-6(5)9/h1-3H,(H,10,11)
InChIKey PKTSBFXIHLYGEY-UHFFFAOYSA-N
SMILES C(O)(=O)C1=CC=C(F)C(Cl)=C1
CAS DataBase Reference 403-16-7(CAS DataBase Reference)
EPA Substance Registry System Benzoic acid, 3-chloro-4-fluoro- (403-16-7)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H335-H315-H319
Precautionary statements  P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-20/21/22
Safety Statements  37/39-26-36-24/25
WGK Germany  3
TSCA  TSCA listed
HazardClass  IRRITANT
HS Code  29163990
NFPA 704
0
2 0

3-Chloro-4-fluorobenzoic acid price More Price(57)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical C1275 3-Chloro-4-fluorobenzoic Acid >98.0%(GC)(T) 403-16-7 5g $24 2026-04-30 Buy
TCI Chemical C1275 3-Chloro-4-fluorobenzoic Acid >98.0%(GC)(T) 403-16-7 25g $77 2026-04-30 Buy
SynQuest Laboratories 2621-7-02 3-Chloro-4-fluorobenzoic acid 98% 403-16-7 1kg $295 2026-05-22 Buy
Chem-Impex 45374 3-Chloro-4-fluorobenzoic acid ≥98%(GC) 403-16-7 5G $51.6 2026-05-19 Buy
Chem-Impex 45374 3-Chloro-4-fluorobenzoic acid ≥98%(GC) 403-16-7 25G $176.7 2026-05-19 Buy
Product number Packaging Price Buy
C1275 5g $24 Buy
C1275 25g $77 Buy
2621-7-02 1kg $295 Buy
45374 5G $51.6 Buy
45374 25G $176.7 Buy

3-Chloro-4-fluorobenzoic acid Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystal powder

Uses

3-Chloro-4-fluorobenzoic Acid is a useful research chemical compound used as a reactant in the structure-activity relationship study on substituted 1-Benzyl-5-phenyltetrazole P2X7 Antagonists.

Synthesis

3-Chloro-4-fluorobenzoyl chloride

65055-17-6

3-Chloro-4-fluorobenzoic acid

403-16-7

General procedure for the synthesis of 3-chloro-4-fluorobenzoic acid from 3-chloro-4-fluorobenzoyl chloride: 2 g of 3-chloro-4-fluorobenzoyl chloride (99.6% purity, GC [a/a]) was mixed with 4 g of 50% sodium hydroxide solution and 20 g of water, and the reaction was carried out at 60 °C with cautious hydrolysis. After completion of the reaction, the reaction solution was continued to be stirred at room temperature for 2 hours. Subsequently, the reaction mixture was acidified with concentrated hydrochloric acid to pH 1. The precipitated 3-chloro-4-fluorobenzoic acid was washed sequentially with dilute hydrochloric acid and water and then dried. 1.68 g of white powdery 3-chloro-4-fluorobenzoic acid was finally obtained in 92.8% yield of the theoretical value. Melting point of the product: 136 °C (literature value: 136 °C).

References

[1] Patent: US6187952, 2001, B1

3-Chloro-4-fluorobenzoic acid Preparation Products And Raw materials

Raw materials

3-Chloro-4-fluorobenzoyl chloride Water Sodium hydroxide Hydrochloric acid

Preparation Products

3-CHLORO-4-FLUOROBENZYL ALCOHOL 3-Chloro-4-fluorobenzoyl chloride Benzamide, 3-chloro-4-fluoro-N,N-dimethyl- 2,3-Dichloro-4-fluoroaniline 3-Chloro-4-fluorobenzohydrazide

3-Chloro-4-fluorobenzoic acid Suppliers

Global( 331)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+8613336195806 sales@capot.com China 29640 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21588 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Speranza Chemical Co., Ltd. 		+86-86-075521030354 +8618688942810 sophieliu@speranzachem.com China 923 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29815 58
Changzhou Ansciep Chemical Co., Ltd. 		+86 519 86305871 sales@ansciepchem.com CHINA 4241 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10404 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Changzhou Ditong Chemical Co.,Ltd 		+86-0519-88298848 info@edengenechem.com China 2176 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
Speranza Chemical Co., Ltd. 		55
career henan chemical co 		58
Changzhou Ansciep Chemical Co., Ltd. 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
Accela ChemBio Inc. 		58
Changzhou Ditong Chemical Co.,Ltd 		58
Alchem Pharmtech,Inc. 		58

View Lastest Price from 3-Chloro-4-fluorobenzoic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-Chloro-4-fluorobenzoic acid pictures 2026-05-25 3-Chloro-4-fluorobenzoic acid
403-16-7
 US $80.00 / KG 1KG 98% 20 tons Speranza Chemical Co., Ltd.
3-Chloro-4-fluorobenzoic acid pictures 2021-07-13 3-Chloro-4-fluorobenzoic acid
403-16-7
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
3-Chloro-4-fluorobenzoic acid pictures 2021-07-10 3-Chloro-4-fluorobenzoic acid
403-16-7
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

3-Chloro-4-fluorobenzoic acid Spectrum

3-Chloro-4-fluorobenzoic acid(403-16-7)1HNMR

403-16-7(3-Chloro-4-fluorobenzoic acid)Related Search:

Benzyl chloroformate 3-Chloroperoxybenzoic acid 4-(Chloromethyl)benzoic acid 3-Chloro-4-fluorobenzonitrile 4-Fluorobenzoic acid
(+)-MENTHYL CHLOROFORMATE Pentyl chloroformate Isobutyl chloroformate 3-CHLORO-2,4,5,6-TETRAFLUOROBENZOIC ACID 3-Chloro-2,4,5-trifluorobenzoic acid
3,5-Dichloro-4-fluorobenzoic acid t-butyl chloroformate Methyl chloroformate 3-Chloro-2,4-difluorobenzoic acid 5-CHLORO-2,4-DIFLUOROBENZOIC ACID
Ethyl chloroformate 3-CHLORO-5-FLUOROBENZOIC ACID Difluorochloromethane

1of4

1-chloro-3-fluorobezene 3-Chloro-4-fluorobenzoic acid 98% 3-Chloro-4-fluorobenzoicacid98% 3-chloro-4-fluorobenzioc acid 3-Chloro-4-fluorobenzoic Acid, 97+% 3-Chloro-4-fluorobenzoic acid,95% 3-CHLORO-4-FLUOROBENZOIC ACID 4-FLUORO-3-CHLOROBENZOIC ACID TIMTEC-BB SBB003796 RARECHEM AL BO 0274 3-Chloro-4-fluorobenzoic Acid > Benzoic acid, 3-chloro-4-fluoro- TIANFUCHEM--403-16-7--3-Chloro-4-fluorobenzoic acid 403-16-7 C7H4O2ClF ARYL ACID Organic Building Blocks C7 Carbonyl Compounds Carboxylic Acids Building Blocks FINE Chemical & INTERMEDIATES Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts Benzoic acid Fluorobenzene Miscellaneous Acids & Esters Chlorine Compounds Fluorine Compounds C7 Carbonyl Compounds Carboxylic Acids