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ChemicalBook >> CAS DataBase List >>(S)-7-hydroxy-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid

(S)-7-hydroxy-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid

(S)-7-hydroxy-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid Structure
(S)-7-hydroxy-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid structure
CAS No.
1246616-73-8
Chemical Name:
(S)-7-hydroxy-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid
Synonyms
KA8Zea9qpd;Dotiravir Impurity 9;Durutevir Impurity 25;Dotiravir Impurity 18;Dolutegravir Impurity F;Dolutegravir Impurity 62;Dolutegravir Intermediate2;Doultegravir 4-F Impurity G;Dolutegravir Intermediates1;Doultegravir Imp F(Tri cyclic impurity)
CBNumber:
CB02685290
Molecular Formula:
C13H14N2O6
Molecular Weight:
294.26
MDL Number:
MOL File:
1246616-73-8.mol
Product description Number Pack Size Price
(4R,12aS)-7-Hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid 95+% CD11316835 1g $1131
(4R,12As)-7-Hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2h-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic Acid AA000MH8 25mg $2109
(4R,12As)-7-Hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2h-pyrido[1'',2'':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylicAcid H947495 1mg $160
(4R,12aS)-7-Hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylicacid 95+% CD11316835 1g $1131
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(S)-7-hydroxy-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Crysdot CD11316835 (4R,12aS)-7-Hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid 95+% 1246616-73-8 1g $1131 2026-05-27 Buy
aablocks AA000MH8 (4R,12As)-7-Hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2h-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic Acid 1246616-73-8 25mg $2109 2026-05-25 Buy
TRC H947495 (4R,12As)-7-Hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2h-pyrido[1'',2'':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylicAcid 1246616-73-8 1mg $160 2021-12-16 Buy
Crysdot CD11316835 (4R,12aS)-7-Hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylicacid 95+% 1246616-73-8 1g $1131 2021-12-16 Buy
Product number Packaging Price Buy
CD11316835 1g $1131 Buy
AA000MH8 25mg $2109 Buy
H947495 1mg $160 Buy
CD11316835 1g $1131 Buy

(S)-7-hydroxy-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid Chemical Properties,Uses,Production

Uses

(4R,12As)-7-Hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2h-pyrido[1'',2'':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic Acid is an intermediate used in the synthesis of Defluoro Dolutegravir (D228715), which is an impurity of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.

(S)-7-hydroxy-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

(S)-7-hydroxy-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid Suppliers

Global( 45)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21588 55
Lianyungang happen teng technology co., LTD 		15950718863 wang666xt@163.com CHINA 295 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29815 58
SIMAGCHEM CORP 		+86-5922680277 +86-13806087780 sale@simagchem.com China 17346 58
AFINE CHEMICALS LIMITED 		+86-0571-85134551 sales@afinechem.com China 15074 58
Baoji Guokang Healthchem co.,ltd 		+8615604608665 15604608665 dominicguo@gk-bio.com CHINA 9414 58
changzhou huayang technology co., ltd 		+8615250961469 2571773637@qq.com China 9653 58
sgtlifesciences pvt ltd 		+8617013299288 dj@sgtlifesciences.com China 12373 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418684 +8618949823763 sales@tnjchem.com China 25356 58
Zhengzhou Anbu Chem Co.,Ltd 		+86-0371-88006763; +8615988602810 sales@anbuchem.com China 3016 58
Supplier Advantage
Henan Tianfu Chemical Co.,Ltd. 		55
Lianyungang happen teng technology co., LTD 		58
career henan chemical co 		58
SIMAGCHEM CORP 		58
AFINE CHEMICALS LIMITED 		58
Baoji Guokang Healthchem co.,ltd 		58
changzhou huayang technology co., ltd 		58
sgtlifesciences pvt ltd 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Zhengzhou Anbu Chem Co.,Ltd 		58

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(S)-7-hydroxy-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid pictures 2019-07-06 (S)-7-hydroxy-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid
1246616-73-8
 $1.00 1kg 95%-99% 100kg Career Henan Chemical Co
Dolutegravir Impurity F Dolutegravir impurity 7/(4R,12As)-7-Hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2h-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic Acid (S)-7-hydroxy-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid (Related Reference) (S)-7-hydroxy-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid (4R,12aS)-3,4,6,8,12,12a-Hexahydro-7-hydroxy-4-methyl-6,8-dioxo-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid Dolutegravir Intermediates1 (4R,12aS)-7-Hydroxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxylic acid Dolutegravir Intermediate2 2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid, 3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aS)- Doultegravir 4-F Impurity G Doultegravir Imp F(Tri cyclic impurity) (S)-7-hydroxy-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1... (S)-7-hydroxy-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-c KA8Zea9qpd (4r，12As)-7-hydroxy-4-methyl-6，8-dioxo-3，4，6，8，12，12a-hexahydro-2h-pyrido[1'，2':4，5]pyrazino[2，1-b][1，3]oxazine-9-carboxylic acid Dotiravir Impurity 9 Galactose Impurity 4 (Galactose EP Impurity D) Dolutegravir Impurity 62 Durutevir Impurity 25 (4R,12aS)-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carbox (4R,12aS)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid Dotiravir Impurity 18 1246616-73-8