Oxaloacetic acid
- CAS No.
- 328-42-7
- Chemical Name:
- Oxaloacetic acid
- Synonyms
- OXALOACETIC ACID;OXALACETIC ACID;2-OXOSUCCINIC ACID;OAA;oxalacetic;NSC 77688;NSC 284205;2-OXOSUCCINIC;OXLACETIC ACID;oxaloaceticaci
- CBNumber:
- CB0271682
- Molecular Formula:
- C4H4O5
- Molecular Weight:
- 132.07
- MDL Number:
- MFCD00002592
- MOL File:
- 328-42-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Oxaloacetic acid ≥97% (HPLC) | O4126 | 1g | $65.6 |
| Oxalacetic Acid >97.0%(T) | O0072 | 5g | $58 |
| Oxalacetic Acid >97.0%(T) | O0072 | 25g | $168 |
| Oxaloacetic Acid | 30280 | 5g | $81 |
| Oxaloacetic Acid | 30280 | 50g | $475 |
| More product size | |||
| Melting point | 161 °C (dec.)(lit.) |
|---|---|
| Boiling point | 163.94°C (rough estimate) |
| Density | 1.3067 (rough estimate) |
| vapor pressure | 0.003Pa at 20℃ |
| refractive index | 1.4000 (estimate) |
| Flash point | 88°C |
| storage temp. | -20°C |
| solubility | H2O: 100 mg/mL |
| pka | 2.22(at 25℃) |
| form | powder |
| color | White to off-white |
| PH | 3.05(1 mM solution);2.29(10 mM solution);1.68(100 mM solution) |
| biological source | synthetic (organic) |
| Water Solubility | soluble |
| Merck | 14,6909 |
| BRN | 1705475 |
| Stability | Stable. Incompatible with strong oxidizing agents. Keep refrigerated. |
| InChI | 1S/C4H4O5/c5-2(4(8)9)1-3(6)7/h1H2,(H,6,7)(H,8,9) |
| InChIKey | KHPXUQMNIQBQEV-UHFFFAOYSA-N |
| SMILES | OC(=O)CC(=O)C(O)=O |
| LogP | -1.04 at 20℃ |
| CAS DataBase Reference | 328-42-7(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 2F399MM81J |
| NIST Chemistry Reference | Oxalacetic acid(328-42-7) |
| EPA Substance Registry System | Oxalacetic acetic (328-42-7) |
| UNSPSC Code | 12352205 |
| NACRES | NA.75 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34 | |||||||||
| Safety Statements | 26-36/37/39-45 | |||||||||
| RIDADR | UN 3261 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29183000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 | |||||||||
| NFPA 704 |
|
Oxaloacetic acid price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | O4126 | Oxaloacetic acid ≥97% (HPLC) | 328-42-7 | 1g | $65.6 | 2025-07-31 | Buy |
| TCI Chemical | O0072 | Oxalacetic Acid >97.0%(T) | 328-42-7 | 5g | $58 | 2025-07-31 | Buy |
| TCI Chemical | O0072 | Oxalacetic Acid >97.0%(T) | 328-42-7 | 25g | $168 | 2025-07-31 | Buy |
| Cayman Chemical | 30280 | Oxaloacetic Acid | 328-42-7 | 5g | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 30280 | Oxaloacetic Acid | 328-42-7 | 50g | $475 | 2024-03-01 | Buy |
Oxaloacetic acid Chemical Properties,Uses,Production
Description
Oxaloacetic acid, also known as oxalacetic acid, is is an α-keto acid and a key component of cellular metabolism in its conjugate base form, oxaloacetate. Oxaloacetate reacts with acetyl-coenzyme A (acetyl-CoA; ) and water to form citrate in the first step of the citric acid cycle and is regenerated by oxidation of L-malate in the final step. It is an intermediate in gluconeogenesis that is formed in mitochondria via carboxylation of pyruvate and subsequently decarboxylated and phosphorylated to form phosphoenolpyruvate. It can be converted to aspartate via addition of an amino group from glutamate. Oxaloacetate (30 μmol/min per 100 g for 30 minutes, i.v.) reduces blood glutamate levels, severity of neurological dysfunction, and brain edema in a rat model of closed head injury.
Chemical Properties
off-white crystals
Uses
Oxaloacetic acid is a substrate for malate dehydrogenase and oxaloacetate decarboxylase. It is an inhibitor of succinic dehydrogenase. It is four carbon dicarboxylic acid that is an intermediate in the citric acid cycle and glucogenesis.
Uses
Use as a TCA (Krebs cycle) intermediate supplement in hybridoma cell culture applications. Enhances hybridoma growth and productivity.
Definition
ChEBI: Oxaloacetic acid is an oxodicarboxylic acid that is succinic acid bearing a single oxo group. It has a role as a metabolite and a geroprotector. It is an oxo dicarboxylic acid and a C4-dicarboxylic acid. It is functionally related to a succinic acid. It is a conjugate acid of an oxaloacetate(2-).
General Description
Oxaloacetic acid is a dicarboxylic acid. It is an intermediate in the citric acid cycle. It is highly soluble in water and is present ubiquitously. It is produced in the mitochondria by the action of pyruvate carboxylase on pyruvate. Breakdown products of oxaloacetate includes malate, pyruvate and aspartic acid.
Flammability and Explosibility
Not classified
Biological Activity
Oxalacetic acid (Oxaloacetic acid, 2-Oxosuccinic acid, Ketosuccinic acid) is an intermediate of the citric acid cycle, where it reacts with acetyl-CoA to form citrate, catalysed by citrate synthase. It is also involved in gluconeogenesis, urea cycle, glyoxylate cycle, amino acid synthesis, and fatty acid synthesis. Oxaloacetate is also a potent inhibitor of Complex II.
Biochem/physiol Actions
Oxaloacetic acid being an intermediate in the tri carboxylic cycle is central to metabolism. It is part of gluconeogenesis pathway. Mutation in pyruvate carboxylase leads to decreased production of oxaloacetate. It inhibits succinate dehydrogenase and is a key regulator of mitochondrial metabolism.
Purification Methods
Crystallise it from boiling EtOAc, or from hot Me2CO/hot *C6H6. [Beilstein 3 IV 1808.]
References
[1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] ALEXANDER ZLOTNIK . Brain neuroprotection by scavenging blood glutamate[J]. Experimental Neurology, 2007, 203 1: Pages 213-220. DOI: 10.1016/j.expneurol.2006.08.021
Oxaloacetic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8753 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-17392712697 | 1022@dideu.com | China | 3995 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5241 | 58 |
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 1006 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3692 | 58 |
| Watson Biotechnology Co.,Ltd | +86-18186686046 +86-18186686046; | sales01@watsonbiotech.cn | China | 5742 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21595 | 55 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
View Lastest Price from Oxaloacetic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-02-28 | Oxalacetic acid
328-42-7
|
US $0.00-0.00 / kg | 1kg | 99% | 20MT | Watson Biotechnology Co.,Ltd | |
 |
2026-02-26 | Oxaloacetic acid
328-42-7
|
US $42.00 / mg | 98.27% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-01-30 | Oxobutanedioic acid
328-42-7
|
US $1.00 / kg | 1kg | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- Oxalacetic acid
328-42-7
- US $0.00-0.00 / kg
- 99%
- Watson Biotechnology Co.,Ltd
-
- Oxaloacetic acid
328-42-7
- US $42.00 / mg
- 98.27%
- TargetMol Chemicals Inc.
-
- Oxobutanedioic acid
328-42-7
- US $1.00 / kg
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
