SAR407899
- CAS No.
- 923359-38-0
- Chemical Name:
- SAR407899
- Synonyms
- 1(2H)-Isoquinolinone, 6-(4-piperidinyloxy)-;SAR407899 free base;SAR407899, 10 mM in DMSO;6-(piperidin-4-yloxy)isoquinolin-1(2H)-one;-6-(piperidin-4-yloxy)-2H-isoquinolin-1-one;SAR 407899,Rho-associated kinase,ROK,Rho-kinase,ROCK,Rho-associated protein kinase,SAR407899,inhibit,SAR-407899,Inhibitor
- CBNumber:
- CB02735537
- Molecular Formula:
- C14H16N2O2
- Molecular Weight:
- 244.29
- MDL Number:
- MOL File:
- 923359-38-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 517.8±50.0 °C(Predicted) |
|---|---|
| Density | 1.193±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : 6 mg/mL (24.56 mM; Need warming) |
| form | Powder |
| pka | 12.79±0.20(Predicted) |
| color | Light yellow to yellow |
| FDA UNII | 3B974D670O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
SAR407899 price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21717 | SAR407899 ≥98% | 923359-38-0 | 1mg | $41 | 2026-04-30 | Buy |
| Cayman Chemical | 21717 | SAR407899 ≥98% | 923359-38-0 | 5mg | $178 | 2026-04-30 | Buy |
| Cayman Chemical | 21717 | SAR407899 ≥98% | 923359-38-0 | 10mg | $312 | 2026-04-30 | Buy |
| Cayman Chemical | 21717 | SAR407899 ≥98% | 923359-38-0 | 25mg | $680 | 2026-04-30 | Buy |
| ChemScene | CS-3570 | SAR407899 99.60% | 923359-38-0 | 5mg | $65 | 2026-06-04 | Buy |
SAR407899 Chemical Properties, Uses, Production
Uses
SAR407899 is a selective, potent and ATP-competitive ROCK inhibitor, with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human and rat ROCK-2, respectively. SAR407899 shows stable inhibition of migrasome formation.
in vivo
SAR407899 (3 mg/kg, i.v.) inhibits ROCK-mediated phosphorylation of MYPTT696 in thoracic aorta of spontaneously hypertensive rats (SHRs). SAR407899 (0.01-0.30 mg/kg, i.v.) efficiently reduces pressor responses to vasoconstrictor agents in rats. SAR407899 (1, 3, 10, and 30 mg/kg, p.o.) dose dependently lowers blood pressure in hypertensive SHRs[1]. SAR407899 (1-3 mg/kg, i.v. or 3, 10 mg/kg, p.o.) increases the length of the penis in healthy rabbits. SAR407899 (3-10 mg/kg, p.o.) also dose-dependently increases penile length in diabetic rabbits[2].
IC 50
ROCK-2: 102 nM (IC50); ROCK-1: 276 nM (IC50)
References
[1] Lhn M, et al. Pharmacological characterization of SAR407899, a novel rho-kinase inhibitor. Hypertension. 2009 Sep;54(3):676-83. DOI:10.1161/HYPERTENSIONAHA.109.134353
[2] Guagnini F, et al. Erectile properties of the Rho-kinase inhibitor SAR407899 in diabetic animals and human isolated corpora cavernosa. J Transl Med. 2012 Mar 23;10:59. DOI:10.1186/1479-5876-10-59
[3] Puzhong Lu, et al. Chemical screening identifies ROCK1 as a regulator of migrasome formation. Cell Discov. 2020 Aug 4;6(1):51. DOI:10.1038/s41421-020-0179-6
SAR407899 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Tongling HengYou Biotechnology Co., Ltd. | 021-50426030 13856289449;13124863828 | 2630597085@qq.com | China | 1885 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4648 | 60 |
| Zhengzhou Ruke Biological Co., Ltd. | 15981811963 | 1410472904@qq.com | China | 5824 | 58 |
| Henan Alfachem Co.,Ltd. | 0371-55051623 18137891487 | 3983243027@qq.com | China | 9973 | 58 |
| Taizhou Crene Biotechnology Co. Ltd. | +86-0576-88813233 +86-13396860566 | sales@pharm-intermediates.com | China | 1976 | 58 |
