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3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide

3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide Structure
3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide structure
CAS No.
1228779-96-1
Chemical Name:
3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide
Synonyms
THP-sulfonamide;3-Nitro-4-[[(tetrahydropyran-4-yl)methyl]amino]benzenesulfonamide;124267;abt-1－199;EOS-60659;Venetoclax Inter.;ABT-199 intermedate3;Venclexta Impurity 2;Venetoclax Intermediate;Venetoclax Intermediate 4
CBNumber:
CB02735683
Molecular Formula:
C12H17N3O5S
Molecular Weight:
315.35
MDL Number:
MFCD28142285
MOL File:
1228779-96-1.mol
MSDS File:
SDS
Last updated:2026-05-27 17:33:07
Product description Number Pack Size Price
3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide 132849 25.00g $49
3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide 132849 100.00g $145
3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide 132849 500.00g $584
3-nitro-4-[(oxan-4-ylmethyl)amino]benzene-1-sulfonamide 97.0% N17774 250mg $19
3-nitro-4-[(oxan-4-ylmethyl)amino]benzene-1-sulfonamide 97.0% N17774 1g $23
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3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide Properties

Melting point 188 - 191°C
Boiling point 542.0±60.0 °C(Predicted)
Density 1.412±0.06 g/cm3(Predicted)
storage temp. 2-8°C(protect from light)
solubility DMSO (Slightly), Methanol (Slightly)
pka 9.58±0.60(Predicted)
form Solid
color Yellow to Dark Yellow
InChI InChI=1S/C12H17N3O5S/c13-21(18,19)10-1-2-11(12(7-10)15(16)17)14-8-9-3-5-20-6-4-9/h1-2,7,9,14H,3-6,8H2,(H2,13,18,19)
InChIKey HNQRHNYBVWICKB-UHFFFAOYSA-N
SMILES C1(S(N)(=O)=O)=CC=C(NCC2CCOCC2)C([N+]([O-])=O)=C1
CAS DataBase Reference 1228779-96-1
FDA UNII 5I2EU37URS

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2932990090
REACH Registrations Active

3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide price More Price(48)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Matrix Scientific 132849 3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide 1228779-96-1 25.00g $49 2026-05-18 Buy
Matrix Scientific 132849 3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide 1228779-96-1 100.00g $145 2026-05-18 Buy
Matrix Scientific 132849 3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide 1228779-96-1 500.00g $584 2026-05-18 Buy
Synthonix N17774 3-nitro-4-[(oxan-4-ylmethyl)amino]benzene-1-sulfonamide 97.0% 1228779-96-1 250mg $19 2026-05-06 Buy
Synthonix N17774 3-nitro-4-[(oxan-4-ylmethyl)amino]benzene-1-sulfonamide 97.0% 1228779-96-1 1g $23 2026-05-06 Buy
Product number Packaging Price Buy
132849 25.00g $49 Buy
132849 100.00g $145 Buy
132849 500.00g $584 Buy
N17774 250mg $19 Buy
N17774 1g $23 Buy

3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide Chemical Properties,Uses,Production

Uses

3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide is a reagent used in the synthesis of BTK, PI3K and JAK-2 inhibitors.

Uses

3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide is a pharmaceutical intermediate compound used in the preparation of Venetoclax, which is used to treat certain types of chronic lymphocytic leukaemia (CL) or certain types of small lymphocytic lymphoma (SLL).

Synthesis

3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide is prepared by the reaction of 4-Aminomethyltetrahydropyran and 4-Fluoro-3-nitrobenzenesulfonamide. The specific synthesis steps are as follows:
4-Fluoro-3-nitrobenzenesulfonamide (1.0 g, 4.54 mmol), (tetrahydro-2H-pyran-4-yl)methylamine (0.6 g, 4.49 mmol), Triethylamine (1.3 g, 6.81 mmol) was added to 10 ml of tetrahydrofuran solution. After stirring at room temperature for 5 h, the solvent was removed. Add 20ml of methanol to beat, After drying, the product was obtained in an amount of 1.4 g. The yield was 97percent.
3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide synthesis

References

[1] Patent: CN108658983, 2018, A. Location in patent: Paragraph 0116; 0117; 0118
[2] Patent: WO2017/156398, 2017, A1. Location in patent: Paragraph 0322
[3] Patent: WO2010/65865, 2010, A2. Location in patent: Page/Page column 226-227
[4] Patent: US2010/160322, 2010, A1. Location in patent: Page/Page column 86
[5] Patent: US2010/305122, 2010, A1. Location in patent: Page/Page column 118

3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide Preparation Products And Raw materials

Raw materials

4-(Aminomethyl)tetrahydro-2H-pyran 4-Chloro-3-nitrobenzenesulfonamide 4-Fluoro-3-nitrobenzenesulfonamide Tetrahydrofuran Triethylamine

Preparation Products

ABT-199

3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide Suppliers

Global( 226)Suppliers
Supplier Tel Email Country ProdList Advantage
Hangzhou ICH Biofarm Co., Ltd 		+86-0571-28186870; +undefined8613073685410 sales@ichemie.com China 1006 58
Hefei Lbao Physical & Chemical Science Co.,Ltd 		+15184799099 lbaochemicals@gmail.com China 670 58
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13901 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1803 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21588 55
Shanghai Yingrui Biopharma Co., Ltd. 		+86-21-33585366 - 03@ sales03@shyrchem.com CHINA 738 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29815 58
NINGBO INNO PHARMCHEM CO., LTD. 		13867897135 sales@nbinno.com CHINA 923 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10403 58
Supplier Advantage
Hangzhou ICH Biofarm Co., Ltd 		58
Hefei Lbao Physical & Chemical Science Co.,Ltd 		58
Shanghai Daken Advanced Materials Co.,Ltd 		58
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
Shanghai Yingrui Biopharma Co., Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
NINGBO INNO PHARMCHEM CO., LTD. 		58
Shenzhen Nexconn Pharmatechs Ltd 		58

View Lastest Price from 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)-benzenesulfonamide pictures 2026-05-29 3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)-benzenesulfonamide
1228779-96-1
 1KG 98%min 30tons/month WUHAN FORTUNA CHEMICAL CO., LTD
3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide pictures 2026-05-18 3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide
1228779-96-1
 1kg 98% Hefei Lbao Physical & Chemical Science Co.,Ltd
3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfoNamide pictures 2026-01-04 3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfoNamide
1228779-96-1
 1kg 99% 200kg Hangzhou ICH Biofarm Co., Ltd

3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide Spectrum

3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide(1228779-96-1)1HNMR

1228779-96-1(3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide)Related Search:

FETAL BOVINE SERUM USA ORIGIN GAMMA DNA, SINGLE STRANDED, IMM. ON CELLULOSE, FROM CALF THYMUS* 1-Piperazinecarboxylic acid, 4-[3-fluoro-4-(methoxycarbonyl)phenyl]-, 1,1-dimethylethyl ester (2-(4-chlorophenyl)-4,4-diMethylcyclohex-1-enyl)Methanol 5-Amino-3-(trifluoromethyl)picolinonitrile
Apalutamide 5-isothiocyanato-3-(trifluoromethyl)picolinonitrile methyl 2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-4-(piperazin-1-yl)benzoate tert-butyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-bromobenzoate 4-(1-CYANOCYCLOBUTYLAMINO)-2-FLUORO-N-METHYLBENZAMIDE
1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride 4-Bromo-2-fluoro-N-methylbenzamide 2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoic acid 1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine 1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol
ABT-199 Methyl 4-Fluoro-2-{1H-pyrrolo[2,3-b]pyridin-5-yloxy}benzoate 4'-chloro-5,5-diMethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carbaldehyde

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3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide 3-nitro-4-[(oxan-4-ylmethyl)amino]benzene-1-sulfonamide abt-1－199 Venclexta Impurity 2 3-nitro-4-(oxan-4-ylmethylamino)benzenesulfonamide 124267 Venetoclax Intermediate Benzenesulfonamide, 3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]- ABT-199 intermedate3 EOS-60659 Venetoclax Intermediate 4 3-nitro-4-(((tetrahydro-2H-pyran-4 yl)methyl)amino)benzenesulfonamide(For export only) 3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesu... 3-nitro-4-(((tetrahyydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide 2-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide 3-Nitro-4-[[(Tetrahydropyran-4-base)methyl]amino]Benzenesulfonamide Venetoclax Inter. 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMid 3-Nitro-4-[[(tetrahydropyran-4-yl)methyl]amino]benzenesulfonamide THP-sulfonamide 1228779-96-1 1629047-84-9 167093-06-9 1228779-96-1