Pramipexole impurity 7
- CAS No.
- 106092-09-5
- Chemical Name:
- Pramipexole impurity 7
- Synonyms
- Pramipexole-1;PraMipexole IMpurity A;PraMipexole IMpurity C;Pramipexole impurity I;Pramipexole Impurity A1;Paramipexole Impurity-A;Pramipexole Intermediate 1;pramipexole impurities1162;(S)-N-Despropyl PraMipexole;PraMipexole Related CoMpound A
- CBNumber:
- CB0276708
- Molecular Formula:
- C7H11N3S
- Molecular Weight:
- 169.25
- MDL Number:
- MFCD07368003
- MOL File:
- 106092-09-5.mol
| Product description | Number | Pack Size | Price |
| Pramipexole Related Compound A Pharmaceutical Secondary Standard; Certified Reference Material | PHR2010 | 50mg | $631.75 |
| (S)-(?)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole 97% | 757381 | 1g | $85.6 |
| (S)-(-)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole >98.0%(GC)(T) | D4337 | 1g | $67 |
| (S)-(-)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole >98.0%(GC)(T) | D4337 | 5g | $263 |
| Pramipexole Related Compound A United States Pharmacopeia (USP) Reference Standard | 1553768 | 15mg | $1300 |
| More product size | |||
| Melting point | 222-224°C |
|---|---|
| Boiling point | 359.0±42.0 °C(Predicted) |
| Density | 1.313±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
| pka | 9.18±0.20(Predicted) |
| form | Solid |
| color | White to Pale Beige |
| optical activity | Consistent with structure |
| Stability | Light Sensitive |
| InChI | InChI=1/C7H11N3S/c8-4-1-2-5-6(3-4)11-7(9)10-5/h4H,1-3,8H2,(H2,9,10)/t4-/s3 |
| InChIKey | DRRYZHHKWSHHFT-BYPYZUCNSA-N |
| SMILES | NC1SC2C[C@@H](N)CCC=2N=1 |&1:5,r| |
| CAS DataBase Reference | 106092-09-5(CAS DataBase Reference) |
| FDA UNII | J4N3Y41JML |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P305+P351+P338 |
| target organs | Respiratory system |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26 |
| WGK Germany | 3 |
| HS Code | 29349990 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
Pramipexole impurity 7 price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR2010 | Pramipexole Related Compound A Pharmaceutical Secondary Standard; Certified Reference Material | 106092-09-5 | 50mg | $631.75 | 2025-07-31 | Buy |
| Sigma-Aldrich | 757381 | (S)-(?)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole 97% | 106092-09-5 | 1g | $85.6 | 2023-06-20 | Buy |
| TCI Chemical | D4337 | (S)-(-)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole >98.0%(GC)(T) | 106092-09-5 | 1g | $67 | 2025-07-31 | Buy |
| TCI Chemical | D4337 | (S)-(-)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole >98.0%(GC)(T) | 106092-09-5 | 5g | $263 | 2025-07-31 | Buy |
| Sigma-Aldrich | 1553768 | Pramipexole Related Compound A United States Pharmacopeia (USP) Reference Standard | 106092-09-5 | 15mg | $1300 | 2025-07-31 | Buy |
Pramipexole impurity 7 Chemical Properties,Uses,Production
Chemical Properties
Pale Beige Solid
Uses
(S)-Pramipexole intermediate as dopamine autoreceptor agonist.
Uses
(S)-N-Despropyl Pramipexole is a (S)-Pramipexole (P700745) intermediate as dopamine autoreceptor agonist.
Uses
(S)-N-Despropyl Pramipexole (Pramipexole EP Impurity A; Pramipexole BP Impurity A; Pramipexole USP Related Compound A) is a (S)-Pramipexole (P700755) intermediate as dopamine autoreceptor agonist.
Synthesis
106006-83-1
106092-09-5
General procedure for the synthesis of (S)-2,6-diamino-4,5,6,7-tetrahydrobenzothiazole from 2,6-diamino-4,5,6,7-tetrahydrobenzothiazole: First, 33.8 g of 2,6-diamino-4,5,6,7-tetrahydrobenzothiazole was mixed with 500 mL of water, followed by the addition of 30.0 g of L-(+)-tartaric acid. The reaction mixture was heated to 75°C and stirred for 1 hour. Thereafter, it was cooled to room temperature and stirring was continued for 24 hours. After completion of the reaction, filtration was carried out, the precipitate was washed with water and dried under vacuum at 55°C to 65°C and -0.01 MPa to -0.1 MPa for 8-12 hours to afford 35.1 g of (S)-2,6-diamino-4,5,6,7-tetrahydrobenzothiazolium di-L-(+)-tartrate as crude product with an enantiomeric content of 2.53% (by chiral-HPLC determination). The entire crude product was redissolved in 500 mL of water, heated to 75°C and held for 1 hour, then cooled to room temperature and stirred for 24 hours. It was filtered again, washed with water and dried under the same vacuum conditions for 8-12 hours to give 26.9 g of (S)-2,6-diamino-4,5,6,7-tetrahydrobenzothiazolyl di-L-(+)-tartrate with enantiomeric content reduced to 0.08%. Finally, the entire product was dissolved in a mixture of 200 mL of water and 40 mL of hydrochloric acid and stirred until completely dissolved. Subsequently, 35 drops of aqueous potassium hydroxide solution (mass percent is the ratio of potassium hydroxide to the total mass of the solution) were added to neutralize. The reaction mixture was cooled to room temperature and stirred for 1 h. The reaction mixture was filtered, the precipitate was washed with water and dried under vacuum at 55°C to 65°C and -0.01 MPa to -0.1 MPa for 8-12 h. The final product was 9.43 g of (S)-2,6-diamino-4,5,6,7-tetrahydrobenzothiazole in a yield of 27.9% and enantiomeric content of 0.08%.
References
[1] Journal of Medicinal Chemistry, 2015, vol. 58, # 14, p. 5501 - 5521
[2] Patent: CN108084115, 2018, A. Location in patent: Paragraph 0086; 0089
[3] Journal of Medicinal Chemistry, 1987, vol. 30, # 3, p. 494 - 498
[4] Patent: WO2011/21214, 2011, A2
[5] Investigational New Drugs, 2010, vol. 28, # 4, p. 454 - 465
Pramipexole impurity 7 Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21595 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29830 | 58 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2952 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
View Lastest Price from Pramipexole impurity 7 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-01-04 | (S)-4,5,6,7-Tetrahydro-2,6-benzothiazolediamine
106092-09-5
|
US $0.00 / kg | 1kg | 99.0%min | 5MT | Hangzhou ICH Biofarm Co., Ltd | |
 |
2025-04-04 | (S)-4,5,6,7-Tetrahydro-2,6-benzothiazolediamine
106092-09-5
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2021-08-12 | (S)-4,5,6,7-Tetrahydro-2,6-benzothiazolediamine
106092-09-5
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- (S)-4,5,6,7-Tetrahydro-2,6-benzothiazolediamine
106092-09-5
- US $0.00 / kg
- 99.0%min
- Hangzhou ICH Biofarm Co., Ltd
-
- (S)-4,5,6,7-Tetrahydro-2,6-benzothiazolediamine
106092-09-5
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- (S)-4,5,6,7-Tetrahydro-2,6-benzothiazolediamine
106092-09-5
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
106092-09-5(Pramipexole impurity 7)Related Search:
1of4
