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6-methoxy-1-tetralone

6-methoxy-1-tetralone Structure
6-methoxy-1-tetralone structure
CAS No.
1078-19-9
Chemical Name:
6-methoxy-1-tetralone
Synonyms
6-Methoxy-3,4-dihydronaphthalen-1(2H)-one;6-METHOXY-1-TETRALONE;1(2H)-NAPHTHALENONE, 3,4-DIHYDRO-6-METHOXY-;6-Methoxy;6-METHOXY-3,4-DIHYDRO-2H-NAPHTHALEN-1-ONE;6-Methoxy-3,4-dihydro-1(2H)-naphthalenone;6-METHOXY-1,2,3,4-TETRAHYDRONAPHTHALEN-1-ONE;6-Methoxy-tetalone;6-Methoxy-1-tetraL;6-METHOXY TETRALONE
CBNumber:
CB0277174
Molecular Formula:
C11H12O2
Molecular Weight:
176.21
MDL Number:
MFCD00001695
MOL File:
1078-19-9.mol
MSDS File:
SDS
Last updated:2025-02-06 17:54:05
Product description Number Pack Size Price
6-Methoxy-1-tetralone 99% M25589 25g $63
6-Methoxy-1-tetralone 99% M25589 100g $103
6-Methoxy-1-tetralone >99.0%(GC) M0787 25g $55
6-Methoxy-1-tetralone >99.0%(GC) M0787 250g $318
6-Methoxy-1-tetralone M268690 1g $45
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6-methoxy-1-tetralone Properties

Melting point 77-79 °C (lit.)
Boiling point 171 °C/11 mmHg (lit.)
Density 1.0558 (rough estimate)
refractive index 1.5250 (estimate)
Flash point 171°C/11mm
storage temp. Sealed in dry,Room Temperature
form Fine Crystalline Powder
color Yellow to light brown
PH 5.96 at 23℃ and 10g/L
Merck 14,6000
BRN 972739
InChIKey MNALUTYMBUBKNX-UHFFFAOYSA-N
CAS DataBase Reference 1078-19-9(CAS DataBase Reference)
FDA UNII IA52U30635
NIST Chemistry Reference 1(2H)-Naphthalenone, 3,4-dihydro-6-methoxy-(1078-19-9)
EPA Substance Registry System 1(2H)-Naphthalenone, 3,4-dihydro-6-methoxy- (1078-19-9)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P261-P284-P301+P312+P330-P304+P340-P342+P311
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38-20/21/22
Safety Statements  24/25-36-26
WGK Germany  3
Hazard Note  Irritant
TSCA  Yes
HS Code  29145000
NFPA 704
0
0 0

6-methoxy-1-tetralone price More Price(36)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich M25589 6-Methoxy-1-tetralone 99% 1078-19-9 25g $63 2025-07-31 Buy
Sigma-Aldrich M25589 6-Methoxy-1-tetralone 99% 1078-19-9 100g $103 2025-07-31 Buy
TCI Chemical M0787 6-Methoxy-1-tetralone >99.0%(GC) 1078-19-9 25g $55 2025-07-31 Buy
TCI Chemical M0787 6-Methoxy-1-tetralone >99.0%(GC) 1078-19-9 250g $318 2025-07-31 Buy
TRC M268690 6-Methoxy-1-tetralone 1078-19-9 1g $45 2021-12-16 Buy
Product number Packaging Price Buy
M25589 25g $63 Buy
M25589 100g $103 Buy
M0787 25g $55 Buy
M0787 250g $318 Buy
M268690 1g $45 Buy

6-methoxy-1-tetralone Chemical Properties,Uses,Production

Chemical Properties

yellow to light brown fine crystalline powder

Uses

6-Methoxy-1-tetralone is a reagent useful in the synthesis of (2-(furanyl)vinyl)-1-tetralone chalcones which possesses anticancer agents and inducers of apoptosis.

Definition

ChEBI: 6-Methoxy-1-tetralone is a member of tetralins.

Preparation

(1) Reacting anisole with an acylating agent in Lewis acid and a solvent at the temperature of-10-40 ℃ to generate an intermediate 1, wherein the molar ratio of the Lewis acid to the acylating agent to the anisole is 1-10: 1-10: 1, the Lewis acid is selected from one or more of concentrated sulfuric acid, phosphoric acid, polyphosphoric acid, zinc chloride, aluminum trichloride, superacid and heteropoly acid;
(2) the intermediate 1 does not need to be separated, the temperature is raised to 70-120 ℃, and the intermediate 1 continues to react to generate 6-methoxy-1-tetralone;
(3) cooling the reaction product, adding water to stop the reaction, extracting, purifying and desolventizing to obtain a crude product of the 6-methoxy-1-tetralone, and refining the crude product by a solvent to obtain a high-purity product.

Synthesis Reference(s)

Journal of the American Chemical Society, 64, p. 94, 1942 DOI: 10.1021/ja01253a025
Tetrahedron Letters, 9, p. 2917, 1968 DOI: 10.1016/S0040-4039(00)89611-2

Synthesis

The synthesis of 6-methoxy-1-tetralone is as follows:Eaton's reagent (1.00 mL, 5.31 mmol) was added slowly to a stirred solution of methyl 4-(3-methoxyphenyl)butanoate (4; 0.37g, 1.78 mmol) in DCE (1 mL). The resulting mixture was stirred at 75 °C for 2h under N2 atmosphere. Then, the reaction mixture was allowed to reach room temperature, and was poured over ice-water and extracted with EtOAc (3 × 15 mL). The combined organic extracts were washed successively with brine (2 × 15 mL) and H2O (2 × 20 mL), filtered over Na2SO4 and concentrated under reduced pressure. The resulting brownish oil was fractionated by column chromatography (silica gel, EtOAc-hexanes, 1:9) to obtain 6-methoxy-1-tetralone as ayellowish oil; yield: 0.28 g (91%).    1078-19-9.png

6-methoxy-1-tetralone synthesis

16821-32-2
1078-19-9
Synthesis of 6-methoxy-1-tetralone from 6-METHOXY-1,2,3,4-TETRAHYDRONAPHTHALEN-1-OL

6-methoxy-1-tetralone Preparation Products And Raw materials

Raw materials

FUMING SULFURIC ACID 6-METHOXY-1,2,3,4-TETRAHYDRONAPHTHALENE Detergent

Preparation Products

17-Ethinyl-3,17-dihydroxy-18-methylestra-2,5(10)-diene3-methylether 3-Methoxy-18-methylestra-1,3,5(10),8-tetraen-17-ethylene ketal 17-Ethinyl-17-hydroxy-18-methylestra-5(10),9(11)-dien-3-one-3-ethylene ketal 3-Methoxy-18-methylestra-2,5(10)dien-17-one 17-ethylene ketal 6-CYANO-1-TETRALONE
6-(benzyloxy)-3,4-dihydronaphthalen-1(2H)-one 4-Methoxyphthalic acid 2-Methoxy-6,7,8,9-tetrahydrobenzocyclohepten-5-one 2-[2-(6-methoxytetralin-1-ylidene)-ethyl]-2-methylcyclopentane-1,3-dione 1-CHLORO-6-METHOXY-3,4-DIHYDRO-NAPHTHALENE-2-CARBALDEHYDE
7-METHOXY-4,5-DIHYDRO-NAPHTHO[1,2-D]THIAZOL-2-YLAMINE

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6-methoxy-1-tetralone Suppliers

Global( 446)Suppliers
Supplier Tel Email Country ProdList Advantage
Nanjing Triumpharm Co.,Ltd
+86-02586182925 +86-15105172550 info@triumpharm.com China 129 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8768 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-81148696 +86-17392712697 1022@dideu.com China 3995 58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD 		+86-15350851019; +8615350851019 admin@86-ss.com China 999 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29735 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21614 55
Shanghai Time Chemicals CO., Ltd. 		+86-021-57951555 +8617317452075 jack.li@time-chemicals.com China 1803 55
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070 product@chemlin.com.cn CHINA 3009 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29847 58
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 8497 58
Supplier Advantage
Nanjing Triumpharm Co.,Ltd
58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Shaanxi Dideu Medichem Co. Ltd 		58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD 		58
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
Shanghai Time Chemicals CO., Ltd. 		55
Nanjing ChemLin Chemical Industry Co., Ltd. 		60
career henan chemical co 		58
Jinan Carbotang Biotech Co.,Ltd. 		58

View Lastest Price from 6-methoxy-1-tetralone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
6-methoxy-1-tetralone pictures 2025-11-29 6-methoxy-1-tetralone
1078-19-9
 US $0.00 / KG 1KG 98%min 30tons/month WUHAN FORTUNA CHEMICAL CO., LTD
6-methoxy-1-tetralone pictures 2025-11-27 6-methoxy-1-tetralone
1078-19-9
 US $100.00-75.00 / kg 1kg 99% 5000 HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
6-Methoxytetralone pictures 2025-11-27 6-Methoxytetralone
1078-19-9
 US $10.00 / KG 1KG 99% 5tons Hebei Chuanghai Biotechnology Co., Ltd

6-methoxy-1-tetralone Spectrum

6-Methoxytetralone(1078-19-9)1HNMR6-Methoxytetralone(1078-19-9)IR16-Methoxytetralone(1078-19-9)IR26-Methoxytetralone(1078-19-9)Raman

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6-METHOXY-1,2,3,4-TETRAHYDRONAPHTHALEN-1-ONE 6-METHOXY-1,2,3,4-TETRAHYDRO-1-NAPHTHALENONE 6-METHOXY-1,2,3,4-TETRAHYDRO-1-NAPHTHONE 6-METHOXY-3,4-DIHYDRO-2H-NAPHTHALEN-1-ONE 6-METHOXY-1-TETRALONE 6-METHOXY TETRALONE 6-METHOXY-ALPHA-TETRALONE TIMTEC-BB SBB007549 6-Methoxy-1,2,3,4-tetrahydro-1-naphthalenone for synthesis 3,4-dihydro-6-methoxy-1(2h)-naphthalenon 3,4-Dihydro-6-methoxy-1(2H)-napthalenone 6-Methoxy-3,4-dihydro-1(2H)-naphthalenone 6-Methoxy-tetalone 6-Methoxytetralin-1-one 3,4-Dihydro-6-methoxynaphthalen-1(2H)-one 98% 6-Methoxy-1-tetralone, 99% 25GR 6-METHOXY-1,2,3,4-TETRAHYDRO-1-NAPHTHALE METHOXY(6-)-1-TETRALONE 3,4-DIHYDRO-6-METHOXY-1(2H)-NAPHTHALENONE 1(2H)-NAPHTHALENONE, 3,4-DIHYDRO-6-METHOXY- 6-Metoxy-1-tetralone 6-Methoxy-1-Tetralon 6-METHOXYA-TETRALONE 6-Methoxy 6-Methoxy-l-tetralone 1,2,3,4-Tetrahydro-6-methoxy-1-naphthalenone 1-Oxo-1,2,3,4-tetrahydro-6-methoxynaphthalene 6-Methoxy-1-oxo-1,2,3,4-tetrahydronaphthalene 3,4-Dihydro-6-methoxynaphthalen-1(2H)-one 6-Methoxy-3,4-dihydronaphthalen-1(2H)-one 6-Methoxy-1-tetraL Levonorgestrel Impurity 13 Levonorgestrel Impurity 13 (6-Methoxy-1-tetralone) 6-Methoxy-1-tetralone> 6-Methoxy-3,4-dihydrophthalen-1(2H)-one 6-Methoxy-1-tertralone 1078-19-9 1078-19-1 KETONE Building Blocks C11 to C12 Carbonyl Compounds Organic Building Blocks Ketones Ketone C11 to C12 Carbonyl Compounds Ketones Carbonyl Compounds