2-Chlorocinnamic acid
- CAS No.
- 3752-25-8
- Chemical Name:
- 2-Chlorocinnamic acid
- Synonyms
- AKOS BBB/195;AKOS B004073;AKOS BBS-00006452;Chlorocinnamicacid;RARECHEM BK HC T319;2-Chlorocinnamicaci;o-chloro-cinnamicaci;2-CLOROCINNAMIC ACID;O-CHLOROCINNAMIC ACID;OTAVA-BB BB0125160239
- CBNumber:
- CB0278409
- Molecular Formula:
- C9H7ClO2
- Molecular Weight:
- 182.6
- MDL Number:
- MFCD00004372
- MOL File:
- 3752-25-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 2-Chlorocinnamic Acid >98.0%(GC)(T) | C0974 | 25g | $26 |
| (E)-3-(2-Chlorophenyl)acrylicacid | C428250 | 500mg | $45 |
| (E)-3-(2-Chlorophenyl)acrylicacid | C428250 | 1g | $55 |
| (E)-3-(2-Chlorophenyl)acrylicacid | C428250 | 2.5g | $65 |
| 2-Chlorocinnamic acid | FC71201 | 250g | $77.5 |
| More product size | |||
| Melting point | 208-210 °C(lit.) |
|---|---|
| Boiling point | 260.71°C (rough estimate) |
| Density | 1.2377 (rough estimate) |
| refractive index | 1.5426 (estimate) |
| storage temp. | Room temperature. |
| Water Solubility | Insoluble in water |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| pka | 4.23(at 25℃) |
| form | powder to crystal |
| color | White to Almost white |
| BRN | 1365198 |
| InChI | InChI=1S/C9H7ClO2/c10-8-4-2-1-3-7(8)5-6-9(11)12/h1-6H,(H,11,12) |
| InChIKey | KJRRTHHNKJBVBO-AATRIKPKSA-N |
| SMILES | C(O)(=O)C=CC1=CC=CC=C1Cl |
| CAS DataBase Reference | 3752-25-8(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | LT5X82W7YR |
| NIST Chemistry Reference | 2-Chlorocinnamic acid(3752-25-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H301-H335 | |||||||||
| Precautionary statements | P264-P270-P280-P301+P312+P330-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P501-P261-P280a-P301+P310a-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 20/21/22-36/37/38-22 | |||||||||
| Safety Statements | 36-26-36/37 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | GD8450000 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29124990 | |||||||||
| NFPA 704 |
|
2-Chlorocinnamic acid price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C0974 | 2-Chlorocinnamic Acid >98.0%(GC)(T) | 3752-25-8 | 25g | $26 | 2026-03-19 | Buy |
| TRC | C428250 | (E)-3-(2-Chlorophenyl)acrylicacid | 3752-25-8 | 500mg | $45 | 2021-12-16 | Buy |
| TRC | C428250 | (E)-3-(2-Chlorophenyl)acrylicacid | 3752-25-8 | 1g | $55 | 2021-12-16 | Buy |
| TRC | C428250 | (E)-3-(2-Chlorophenyl)acrylicacid | 3752-25-8 | 2.5g | $65 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC71201 | 2-Chlorocinnamic acid | 3752-25-8 | 250g | $77.5 | 2021-12-16 | Buy |
2-Chlorocinnamic acid Chemical Properties,Uses,Production
Chemical Properties
white to light yellow crystal powder. Insoluble in water, soluble in ethanol, ethyl acetate and other organic solvents.
Uses
2-Chlorocinnamic acid is a kind of trans-cinnamate. It is used in organic synthesis.
Biological Functions
2-Chlorocinnamic acid is a cinnamic acid derivative that inhibits the hydroxylation of phenylpropanoids. It has been shown to inhibit the activity of cinnamic acid derivatives and their hydroxylation in cell lines, which is linked to the inhibition of cellulose acetate synthesis. 2-Chlorocinnamic acid also has an inhibitory effect on the chloride ion and water molecule. The chloride ion may be needed for the formation of hydrochloric acid, which is necessary for cellulose acetate hydrolysis, while water molecules are involved in many biochemical reactions. 2-Chlorocinnamic acid affects human cell lines at temperatures between 10°C and 37°C and at regiospecific sites. This oxidative dehalogenation reaction catalyzed by R. rubra was found to be regiospecific for 2-chlorocinnamic acid; the chloride ion was probably removed after the ring fission reaction.
Synthesis
O-chlorocinnamic acid is prepared by reacting o-phthalaldehyde with malonic acid.
References
[1] Patent: EP1676838, 2006, A1. Location in patent: Page/Page column 17
[2] Patent: WO2006/69799, 2006, A1. Location in patent: Page/Page column 29-30
2-Chlorocinnamic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5235 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 973 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20124 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| Chongqing Soarwin Technology Co., Ltd | +86-15790943001 | crystal@sorawin.cn | China | 421 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21591 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29820 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
View Lastest Price from 2-Chlorocinnamic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | 2-Chlorocinnamic acid
3752-25-8
|
US $9.80 / KG | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-09-25 | 2-Chlorocinnamic acid
3752-25-8
|
US $32.00-1.10 / kg | 1kg | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2025-08-20 | 2-Chlorocinnamic acid
3752-25-8
|
US $0.00-0.00 / Kg | 1Kg | 99.99% | 20 tons | Chongqing Soarwin Technology Co., Ltd |
-
- 2-Chlorocinnamic acid
3752-25-8
- US $9.80 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 2-Chlorocinnamic acid
3752-25-8
- US $32.00-1.10 / kg
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 2-Chlorocinnamic acid
3752-25-8
- US $0.00-0.00 / Kg
- 99.99%
- Chongqing Soarwin Technology Co., Ltd
