Phenyl acetate
- CAS No.
- 122-79-2
- Chemical Name:
- Phenyl acetate
- Synonyms
- Phenol acetate;2-phenylacetate;FEMA 3958;NSC 27795;Acetoxybenzene;Phenyl acetate;BenzoateAcetate;Phenylacetate 99%;Phenyl acetate,97%;Phenyl Acetate >
- CBNumber:
- CB0300805
- Molecular Formula:
- C8H8O2
- Molecular Weight:
- 136.15
- MDL Number:
- MFCD00008699
- MOL File:
- 122-79-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 195-196℃ |
|---|---|
| Boiling point | 196 °C(lit.) |
| Density | 1.073 g/mL at 25 °C(lit.) |
| vapor density | 4.7 |
| refractive index |
n |
| FEMA | 3958 | PHENYL ACETATE |
| FLAVIS Number | 09.688 | Phenyl acetate |
| Flash point | 170 °F |
| storage temp. | Store below +30°C. |
| solubility | 4g/l practically insoluble |
| form | Liquid |
| color | Clear colorless to slightly brown |
| Odor | at 10.00 % in dipropylene glycol. phenolic medicinal animal resinous castoreum woody smoky burnt |
| Odor Type | phenolic |
| Water Solubility | Soluble in water (4 g/L at 20°C). |
| Merck | 14,7267 |
| JECFA Number | 734 |
| BRN | 636458 |
| Henry's Law Constant | 1.3×100 mol/(m3Pa) at 25℃, Brockbank (2013) |
| Dielectric constant | 6.9(20℃) |
| Stability | Stable. Incompatible with strong acids, strong bases, strong reducing agents, strong oxidizing agents. Combustible. |
| InChI | 1S/C8H8O2/c1-7(9)10-8-5-3-2-4-6-8/h2-6H,1H3 |
| InChIKey | IPBVNPXQWQGGJP-UHFFFAOYSA-N |
| SMILES | CC(=O)Oc1ccccc1 |
| LogP | 1.65 |
| CAS DataBase Reference | 122-79-2(CAS DataBase Reference) |
| Substances Added to Food (formerly EAFUS) | PHENYL ACETATE |
| NCI Dictionary of Cancer Terms | phenylacetate |
| FDA UNII | 355G9R500Y |
| EPA Substance Registry System | Acetic acid, phenyl ester (122-79-2) |
| UNSPSC Code | 85151701 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H227-H302 | |||||||||
| Precautionary statements | P210e-P280a-P301+P312a-P501a-P210-P264-P270-P280-P301+P312+P330-P370+P378-P403+P235-P501 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 36 | |||||||||
| RIDADR | NA 1993 / PGIII | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | AJ2800000 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | CBL | |||||||||
| HS Code | 29153900 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| Hazardous Substances Data | 122-79-2(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 orally in rats: 1.63 ml/kg, H. F. Smyth et al., Am. Ind. Hyg. Assoc. J. 30, 470 (1969) | |||||||||
| REACH Registrations | Inactive | |||||||||
| Excepted Quantities | Non-Hazardous | |||||||||
| NFPA 704 |
|
Phenyl acetate price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 108723 | Phenyl acetate 99% | 122-79-2 | 5g | $38.4 | 2026-04-30 | Buy |
| Sigma-Aldrich | 108723 | Phenyl acetate 99% | 122-79-2 | 100g | $68.3 | 2026-04-30 | Buy |
| TCI Chemical | A0043 | Phenyl Acetate >98.0%(GC) | 122-79-2 | 25g | $17 | 2026-04-30 | Buy |
| TRC | TRC-P319150-5G | Phenyl Acetate | 122-79-2 | 5g | $165 | 2026-06-03 | Buy |
| TRC | TRC-P319150-50G | Phenyl Acetate | 122-79-2 | 50g | $370 | 2026-06-03 | Buy |
Phenyl acetate Chemical Properties, Uses, Production
Chemical Properties
Phenyl acetate is a colourless liquid, has an offensive odor. It is a small molecule normally present in the mammalian circulation
in low concentrations.
Uses
Phenyl acetate levels in urine are marker for the diagnosis of some forms of unipolar major depressive disorders. It undergoes Fries rearrangement to form a mixture of o- and p-hydroxyacetophenones which are useful intermediates in manufacture of pharmaceuticals. It is a metabolite of Phenylbutyrate (PB), useful in the treatment of neuroblastoma and lung cancer.
Definition
ChEBI: An acetate ester obtained by the formal condensation of phenol with acetic acid.
Synthesis Reference(s)
Tetrahedron Letters, 29, p. 4567, 1988 DOI: 10.1016/S0040-4039(00)80548-1
Chemical and Pharmaceutical Bulletin, 30, p. 4242, 1982 DOI: 10.1248/cpb.30.4242
Synthetic Communications, 19, p. 1271, 1989 DOI: 10.1080/00397918908054534
General Description
A clear colorless liquid with a sweetish solvent odor. Specific gravity 1.073. Flash point 176°F. Boiling point 383-384°F. Difficult to ignite. Used as a laboratory reagent and in the production of some organic chemicals.
Air & Water Reactions
Slightly soluble in water.
Reactivity Profile
Phenyl acetate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.
Health Hazard
Inhalation or contact with material may irritate or burn skin and eyes. Fire may produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
Safety Profile
Moderately toxic by ingestion. Mildly toxic by skin contact. A skin irritant. Combustible when exposed to heat, flame oroxidizers. To fight fire, use alcohol foam. When heated to decomposition it emits acrid smoke and irritating fumes.
Synthesis
Phenyl acetate is synthesized by reacting phenol with acetic anhydride or acetyl chloride.
Purification Methods
Phenyl acetate acid is freed from phenol and acetic acid by washing (either directly or as a solution in pentane) with aqueous 5% Na2CO3, then with saturated aqueous CaCl2, drying with CaSO4 or Na2SO4, and fractionally distilling under reduced pressure. [Beilstein 6 II 153, 6 III 595, 6 IV 611.]
Toxics Screening Level
The ITSL for phenyl acetate has been changed from 0.04 μg/m3 to 0.1 μg/m3 based on an annual averaging time.
Phenyl acetate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan xinyangruihe Chemical Technology Co., Ltd. | 027-18120580375 18120580375 | 669797270@qq.com | China | 5966 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| shanghai science Bio-Pharmceutical.co,ltd. | 021-021-57872719 13761402923 | 245662540@qq.com | China | 299 | 60 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
Related articles
- What is uses and synthesis of Phenyl acetate?
- Phenyl acetate is mainly used as a solvent and an intermediate in organic synthesis.
- Nov 4,2024
View Latest Price from Phenyl acetate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-17 | Phenyl acetate
122-79-2
|
$29.00 | 99.70% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-07-17 | Phenyl acetate
122-79-2
|
$29.00 | 99.70% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-07-17 | Phenyl acetate
122-79-2
|
$29.00 | 99.70% | 10g | TargetMol Chemicals Inc. |
-
- Phenyl acetate
122-79-2
- $29.00
- 99.70%
- TargetMol Chemicals Inc.
-
- Phenyl acetate
122-79-2
- $29.00
- 99.70%
- TargetMol Chemicals Inc.
-
- Phenyl acetate
122-79-2
- $29.00
- 99.70%
- TargetMol Chemicals Inc.
