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Sacubitril Sodium

Sacubitril Sodium structure

CAS No.: 149690-05-1

Chemical Name:: Sacubitril Sodium

Synonyms: Sacubitril sodium;Valsartan Sodium;(αR,γS)- γ-[(3-Carboxy -1-oxopropyl) amino]-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester sodium salt;Thacubatra sodium;AHU-377 sodium salt;Sacubitril Sodium Salt;AHU-377 (Sacubitril free base);Saccubitril Valsartan Sodium Impurity A-1;Sodium,4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoate;sodium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate

CBNumber:: CB03069990

Molecular Formula:: C24H28NNaO5

Molecular Weight:: 433.47259

MDL Number:: MFCD32004488

MOL File:: 149690-05-1.mol

MSDS File:: SDS

Last updated:2026-07-27 17:00:41

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Sacubitril Sodium Properties

Melting point	163-165°C
storage temp.	-20°C, Hygroscopic
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
color	White to Off-White
Stability	Hygroscopic
InChIKey	RRTBVEJIZWGATF-OIRVNKSWNA-M
SMILES	[Na+].C([O-])(=O)CCC(N[C@@H](C[C@@H](C)C(OCC)=O)CC1=CC=C(C2=CC=CC=C2)C=C1)=O \|&1:8,10,r\|
FDA UNII	MOP72GEP8Z

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H319-H413
Precautionary statements	P264-P280-P305+P351+P338-P337+P313P

Sacubitril Sodium price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Biosynth	FS165528	Sacubitril sodium	149690-05-1	0.1g	$150	2026-06-04	Buy
Biosynth	FS165528	Sacubitril sodium	149690-05-1	0.05g	$150	2026-06-04	Buy
Biosynth	FS165528	Sacubitril sodium	149690-05-1	0.25g	$214.17	2026-06-04	Buy
Biosynth	FS165528	Sacubitril sodium	149690-05-1	0.5g	$356.95	2026-06-04	Buy
Biosynth	FS165528	Sacubitril sodium	149690-05-1	1g	$571.12	2026-06-04	Buy

Product number	Packaging	Price	Buy
FS165528	0.1g	$150	Buy
FS165528	0.05g	$150	Buy
FS165528	0.25g	$214.17	Buy
FS165528	0.5g	$356.95	Buy
FS165528	1g	$571.12	Buy

Sacubitril Sodium Chemical Properties,Uses,Production

Description

Sacubitril Sodium is a potent orally active NEP (enkephalinase) inhibitor with an IC50 of 5 nM. Sacubitril Sodium enhances the tone of the natriuretic peptide (NP) system and exerts significant antihypertensive effects. Sacubitril Sodium is a component of the heart failure drug LCZ696. Sacubitril Sodium is used in heart failure, hypertension and COVID-19 studies.

Uses

Sacubitril Sodium Salt is a salt of Sacubitril, an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.

in vivo

In normotensive rats, pretreatment with Sacubitril sodium (3, 10 and 30 mg/kg, PO.) augments ANP-evoked plasma cGMP levels by 2.4, 3.3 and 4.0 fold, respectively (4h AUC compared to vehicle)^[1].
Sacubitril sodium (30 and 100 mg/kg, PO) produces a dose-dependent antihypertensive effect in Dahl-SS rats^[1].

Sacubitril Sodium synthesis

Synthesis of Sacubitril Sodium from Succinic anhydride and (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride

Sacubitril Sodium Preparation Products And Raw materials

Raw materials

AHU-377 (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride Succinic anhydride

Preparation Products

Sacubitril Sodium Suppliers

Global( 132)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
CHANGZHOU PHARMACEUTICAL FACTORY	0519-88821493 18915891730	shm@czpharma.com	China	176	58
Hubei Chenxin Pharmaceutical Co., Ltd.	18696113233	like1076463918@163.com	China	3117	58
S.Z. PhyStandard Bio-Tech. Co., Ltd.	0755-4000505016 13380397412	3001272453@qq.com	China	5000	50
Shanghai Pansopharm Technology Co., Ltd.	021-20962833 15316628753	sales@pansopharm.com	China	863	60
INTERCHEMIE NANJING PHARMATECH CO., LTD	13656237714 13656237714;	xiaokunfu@kyyykj.com	China	297	55
Shanghai Haozhixiang Biotechnology Co., Ltd	526763801 13301653310	526763801@qq.com	China	7580	55
Shanghai QianYan Bio-technology Co., Ltd	02781293128	orders@biochemsafebuy.com	China	9904	55
Cangzhou Enke Pharma-tech Co., Ltd.	0317-5296180 15533709196	enkepharma@126.com	China	2495	55
ShangHai Biochempartner Co.,Ltd	177-54423994 17754423994	2853530910@QQ.com	China	8000	62
Hubei widely chemical technology Co., Ltd.	17771478861 13419635609	3525818213@qq.com	China	1887	55

Supplier	Advantage
CHANGZHOU PHARMACEUTICAL FACTORY	58
Hubei Chenxin Pharmaceutical Co., Ltd.	58
S.Z. PhyStandard Bio-Tech. Co., Ltd.	50
Shanghai Pansopharm Technology Co., Ltd.	60
INTERCHEMIE NANJING PHARMATECH CO., LTD	55
Shanghai Haozhixiang Biotechnology Co., Ltd	55
Shanghai QianYan Bio-technology Co., Ltd	55
Cangzhou Enke Pharma-tech Co., Ltd.	55
ShangHai Biochempartner Co.,Ltd	62
Hubei widely chemical technology Co., Ltd.	55

View Lastest Price from Sacubitril Sodium manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-25	Sacubitril sodium 149690-05-1	$2.00-5.00	1kg	99%	100kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2026-08-20	Sacubitril Sodium 149690-05-1	$1.10	1g	99.9%	100 Tons Min	Dideu Industries Group Limited
2026-08-08	Sacubitril sodium 149690-05-1	$87.00-191.00		99.97%	10g	TargetMol Chemicals Inc.

Sacubitril sodium
149690-05-1
$2.00-5.00
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Sacubitril Sodium
149690-05-1
$1.10
99.9%
Dideu Industries Group Limited

Sacubitril sodium
149690-05-1
$87.00-191.00
99.97%
TargetMol Chemicals Inc.

Sacubitril Sodium Spectrum

Sacubitril Sodium(149690-05-1)¹HNMR

149690-05-1(Sacubitril Sodium )Related Search:

LCZ696(valsartan + sacubitril) impurity 35 [1,1′-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-, 4-methyl ester, calcium salt (2:1), (αR,γS)- LCZ696(valsartan + sacubitril) impurity 31 [1,1'-Biphenyl]-4-pentanoic acid, γ-(acetylamino)-α-methyl-, (αR,γS)- LCZ696(valsartan + sacubitril) impurity 34

2S,4R-Sacubitril Sacubatrava valsartan sodium hydrate Sacubitril Impurity 43 Sacubitril Methyl esterQ: What is Sacubitril Methyl ester Q: What is the CAS Number of Sacubitril Methyl ester Sacubitrilat-d5

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Sacubitril Sodium Salt Sacubitril sodium sodium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate AHU-377 (Sacubitril free base) AHU-377 sodium salt Sodium,4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoate Thacubatra sodium Sacubitril Sodium: Sodium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate (αR,γS)- γ-[(3-Carboxy -1-oxopropyl) amino]-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester sodium salt (Intermediate of Sacubitril Valsartan Sodium) 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid, sodium salt Saccubitril Valsartan Sodium Impurity A-1 (αR,γS)- γ-[(3-Carboxy -1-oxopropyl) amino]-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester sodium salt Valsartan Sodium 149690-05-1