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ChemicalBook >> CAS DataBase List >>ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE

ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE

ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE Structure
ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE structure
CAS No.
4506-71-2
Chemical Name:
ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE
Synonyms
105461;EOS-62180;NSC 99005;AKOS 92528;AKOS B000472;AKOS BBB/012;AKOS MSC-0429;ASISCHEM N39354;AKOS BBS-00004584;CBI-BB ZERO/004885
CBNumber:
CB0312695
Molecular Formula:
C11H15NO2S
Molecular Weight:
225.31
MDL Number:
MFCD00005862
MOL File:
4506-71-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 17:36:26
Product description Number Pack Size Price
Ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 97% 159182 1g $39.1
Ethyl 2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate >98.0%(T) A1355 10g $91
Ethyl 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate FE59050 0.1kg $150
Ethyl 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate FE59050 0.025kg $150
Ethyl 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate 98% OR321020 1g $47
More product size
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ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE Properties

Melting point 114-116 °C(lit.)
Boiling point 407.5±45.0 °C(Predicted)
Density 1.235±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
pka 0.53±0.20(Predicted)
form Fine Crystalline Powder
color Yellow
InChI InChI=1S/C11H15NO2S/c1-2-14-11(13)9-7-5-3-4-6-8(7)15-10(9)12/h2-6,12H2,1H3
InChIKey CDYVTVLXEWMCHU-UHFFFAOYSA-N
SMILES C12CCCCC=1C(C(OCC)=O)=C(N)S2
CAS DataBase Reference 4506-71-2(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)Exclamation Mark (GHS07)
GHS06,GHS07
Signal word  Warning
Hazard statements  H301-H311-H332-H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P280-P302+P352-P322
Hazard Codes  Xn,Xi
Risk Statements  36/37/38-22
Safety Statements  36/37/39-26-22
WGK Germany  3
HazardClass  IRRITANT
HS Code  29339900
Storage Class 11 - Combustible Solids
NFPA 704
1
2 0

ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE price More Price(44)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 159182 Ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 97% 4506-71-2 1g $39.1 2023-06-20 Buy
TCI Chemical A1355 Ethyl 2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate >98.0%(T) 4506-71-2 10g $91 2026-04-30 Buy
Biosynth FE59050 Ethyl 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate 4506-71-2 0.1kg $150 2026-06-04 Buy
Biosynth FE59050 Ethyl 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate 4506-71-2 0.025kg $150 2026-06-04 Buy
Apolloscientific OR321020 Ethyl 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate 98% 4506-71-2 1g $47 2026-06-04 Buy
Product number Packaging Price Buy
159182 1g $39.1 Buy
A1355 10g $91 Buy
FE59050 0.1kg $150 Buy
FE59050 0.025kg $150 Buy
OR321020 1g $47 Buy

ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE Chemical Properties,Uses,Production

Chemical Properties

yellow fine crystalline powder

Uses

Ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate was used in the preparation of:

  • thienopyrimidine derivatives
  • azo dyes
  • N-(3-ethoxycarbonyl-4,5,6,7-tetrahydrobenzo[b]thien-2-yl)-2-aryl hydrazono-3-oxobutanamide derivatives
  • tetrahydrobenzo[b]thiophene dyes

Synthesis

Cyclohexanone

108-94-1

Ethyl cyanoacetate

105-56-6

ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE

4506-71-2

GENERAL METHOD: Cyclohexanone (1 mmol), ethyl cyanoacetate (1 eq.), morpholine (1 eq.), and elemental sulfur (1 eq.) were dissolved in 5 mL of ethanol at 0°C and the reaction was stirred overnight. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The crude product was extracted three times with ethyl acetate, the organic layers were combined and dried over anhydrous sodium sulfate. After drying, the solvent was again evaporated under reduced pressure. The final product was obtained as purified ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate by recrystallization from a mixed methanol/water solvent as a yellow crystalline solid. Yield: 98%, melting point 134-135 °C. 1H NMR (400 MHz, DMSO-d6) δ 1.20 (3H, t, J = 7.1 Hz, CH3), 1.60-1.65 (4H, m, CH2), 2.35-2.37 (2H, m, CH2), 2.55-2.56 (2H, m, CH2), 4.11 (2H , q, J = 7.3 Hz, OCH2CH3), 7.14 (2H, br s, NH2).13C NMR (100 MHz, DMSO-d6) δ 14.18 (CH3), 22.34 (CH2), 22.76 (CH2), 23.88 (CH2), 26.49 (CH2), 58.71 (OCH2), 103.16 (Cq), 115.96 (Cq), 131.50 (Cq), 163.19 (Cq), 165.32 (C=O).

References

[1] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 18, p. 4228 - 4240
[2] Synthetic Communications, 2010, vol. 40, # 14, p. 2067 - 2074
[3] European Journal of Medicinal Chemistry, 2016, vol. 122, p. 619 - 634
[4] Journal of Sulfur Chemistry, 2014, vol. 35, # 3, p. 261 - 269
[5] Tetrahedron Letters, 2007, vol. 48, # 18, p. 3171 - 3172

ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Sulfur Piperidine Cyclohexanone Ethyl cyanoacetate Ethanol
Morpholine

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Preparation Products

4-((3-(ethoxycarbonyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)amino)-4-oxobutanoic acid [1]Benzothieno[2,3-d]pyrimidin-4(1H)-one, 2,3,5,6,7,8-hexahydro-3-(3-methoxyphenyl)-2-thioxo- [1]Benzothieno[2,3-d]pyrimidin-4(1H)-one, 2,3,5,6,7,8-hexahydro-3-(2-methoxyphenyl)-2-thioxo-

ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE Suppliers

Global( 216)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21531 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32997 60
HaBo Hong Kong Co., Limited. 		+86-25-18512596065 info@habotech.com CHINA 931 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63645 58
Wuhan Chemwish Technology Co., Ltd 		027-67849912 sales@chemwish.com CHINA 10817 58
CONIER CHEM AND PHARMA LIMITED 		sales@conier.com China 49906 58
career henan chemical co 		+86-0371-86658258 factory@coreychem.com China 29780 58
Richest Group Ltd 		18017061086 oled@richest-group.com CHINA 5597 58
Fuxin Pharmaceutical 		+86-021-021-50872116 contact@fuxinpharm.com China 9976 58
Neostar United (Changzhou) Industrial Co., Ltd. 		+86-0519-85551759 marketing1@neostarunited.com China 8827 58
Supplier Advantage
Henan Tianfu Chemical Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
HaBo Hong Kong Co., Limited. 		58
Alchem Pharmtech,Inc. 		58
Wuhan Chemwish Technology Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
Richest Group Ltd 		58
Fuxin Pharmaceutical 		58
Neostar United (Changzhou) Industrial Co., Ltd. 		58

View Lastest Price from ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE pictures 2026-06-30 ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE
4506-71-2
 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd
ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE pictures 2025-11-18 ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE
4506-71-2
 $1.10 1g 99.00% 100 Tons Dideu Industries Group Limited
ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE pictures 2021-08-12 ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE
4506-71-2
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd

ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE Spectrum

ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE(4506-71-2)MSETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE(4506-71-2)1HNMRETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE(4506-71-2)13CNMRETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE(4506-71-2)IR1ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE(4506-71-2)IR2ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE(4506-71-2)Raman

4506-71-2(ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE)Related Search:

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TIMTEC-BB SBB000654 Ethyl-2-Amino-4,5,6,7-Tetrahydrobenzene(B)Thiophene-3-Carboxlate Ethyl 2-amino-4,5,6,7-tetrahydrobenzothiophene-3-carboxylate 2-Amino-3-carbethoxy-4,5-tetramethylenethiophene, GC 99% 2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid ethyl 4,5,6,7-Tetrahydro-2-aminobenzo[b]thiophene-3-carboxylic acid ethyl ester Ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate,97% Ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate,99% ethyl 2-aminotetrahydrobenzo[b]thiophene-3-carboxylate Ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 97% {Benzo[b]thiophene-3-carboxylic} acid, 2-amino-4,5,6,7-tetrahydro-, ethyl ester 2-Amino-3-carbethoxy-4,5-tetramethylenethiophene 2-Amino-3-ethoxycarbonyl-4,5-tetramethylenethiophene 2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic Acid Ethyl Ester 2-Amino-4,5,6,7-tetrahydro-benzothiophene-3-carboxylic acid ethyl ester Benzo[b]thiophene-3-carboxylic acid, 2-amino-4,5,6,7-tetrahydro-, ethyl ester Et2-N-4,5,6,7-4HBzthiophene carboxylate Ethyl 2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 105461 3-chloro-N-(3-thiophen-2-yl-5-isoxazolyl)propanamide 1-BENZOTHIOPHENE-3-CARBOXYLIC ACID, 2-AMINO-4,5,6,7-TETRAHYDRO-, ETHYL ESTER 2-AMINO-3-ETHOXYCARBONYL-4,5-TETRAMETHYLENETHIOPHENE 2-AMINO-3-ETHOXYCARBONYL-THIENOCYCLOHEXANE 2-AMINO-3-CARBETHOXY-4,5-TETRAMETHYLENETHIOPHENE 2-AMINO-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER ART-CHEM-BB B000472 ASISCHEM N39354 CBI-BB ZERO/004885 ETHYL 2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXYLATE ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE IFLAB-BB F1386-0048 AKOS BBS-00004584 AKOS MSC-0429 AKOS B000472 AKOS 92528 AKOS BBB/012 EOS-62180 NSC 99005 Ethyl 2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate > Ethyl 2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carb ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE ISO 9001：2015 REACH Ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxyl... 4506-71-2 ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE 4506-71-2 Heterocyclic Building Blocks Building Blocks Benzothiophenes Benzothiophenes Building Blocks Heterocyclic Building Blocks Sulphur Derivatives Thiophene