HAMNO
- CAS No.
- 138736-73-9
- Chemical Name:
- HAMNO
- Synonyms
- HAMNO;NSC111847;CID 6335338;MLS000737724;NSC111847,HAMNO;HAMNO (NSC111847);HAMNO >=98% (HPLC);HAMNO, 10 mM in DMSO;HAMNO,inhibit,NSC 111847,NSC-111847,Inhibitor;1-(((2-Hydroxyphenyl)amino)methylene)naphthalen-2(1H)-one
- CBNumber:
- CB03146301
- Molecular Formula:
- C17H13NO2
- Molecular Weight:
- 263.29
- MDL Number:
- MOL File:
- 138736-73-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| HAMNO ≥98% (HPLC) | SML1234 | 5 mg | $129 |
| HAMNO ≥98% (HPLC) | SML1234 | 25 mg | $509 |
| HAMNO ≥95% | 27631 | 1mg | $36 |
| HAMNO ≥95% | 27631 | 5mg | $120 |
| HAMNO ≥95% | 27631 | 10mg | $219 |
| More product size | |||
| Boiling point | 488.8±45.0 °C(Predicted) |
|---|---|
| Density | 1.392±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility |
DMF:30.0(Max Conc. mg/mL);113.94(Max Conc. mM) DMSO:30.0(Max Conc. mg/mL);113.94(Max Conc. mM) DMSO:PBS (pH 7.2) (1:30):0.25(Max Conc. mg/mL);0.95(Max Conc. mM) |
| form | A crystalline solid |
| pka | 9.98±0.35(Predicted) |
| color | Yellow to orange |
| InChIKey | NADCEWZYITXLKJ-KAMYIIQDSA-N |
| SMILES | N(c3c(cccc3)O)\C=C1\c2c(cccc2)C=CC\1=O |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
HAMNO price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1234 | HAMNO ≥98% (HPLC) | 138736-73-9 | 5 mg | $129 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML1234 | HAMNO ≥98% (HPLC) | 138736-73-9 | 25 mg | $509 | 2026-04-30 | Buy |
| Cayman Chemical | 27631 | HAMNO ≥95% | 138736-73-9 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 27631 | HAMNO ≥95% | 138736-73-9 | 5mg | $120 | 2026-04-30 | Buy |
| Cayman Chemical | 27631 | HAMNO ≥95% | 138736-73-9 | 10mg | $219 | 2026-04-30 | Buy |
HAMNO Chemical Properties,Uses,Production
Uses
HAMNO, is a novel protein interaction inhibitor of replication protein A (RPA). It has shown to significantly inhibits colony formation when combined with etoposide.
Biological Activity
HAMNO is a potent and selective inhibitor of replication protein A (RPA) interactions with proteins involved in the replication stress response. HAMNO binds the N-terminal domain of RPA70 and inhibits both ATR autophosphorylation and phosphorylation of RPA32 Ser33 by ATR. HAMNO enhances DNA replication stress in cancer cells and slow tumor growth in vivo.
in vivo
In mice, HAMNO slows the progression of UMSCC11B tumors. Ser33 of RPA32, an ATR substrate, is highly phosphorylated after two hours of treatment with 20 μM of etoposide, which is reduced with the addition of 2 μM HAMNO, and is nearly absent at higher concentrations, demonstrating an in vivo effect of HAMNO as an inhibitor of RPA32 phosphorylation by ATR[1].
HAMNO Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30225 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39039 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Bide Pharmatech Ltd. | 400-400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4843 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9804 | 58 |
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