Serlopitant
- CAS No.
- 931395-42-5
- Chemical Name:
- Serlopitant
- Synonyms
- SGX942;L-Alaninamide, L-arginyl-L-isoleucyl-L-valyl-L-prolyl-;(S)-N-((S)-1-amino-1-oxopropan-2-yl)-1-((S)-2-((2S,3S)-2-((S)-2-amino-5-guanidinopentanamido)-3-methylpentanamido)-3-methylbutanoyl)pyrrolidine-2-carboxamide
- CBNumber:
- CB03159976
- Molecular Formula:
- C25H47N9O5
- Molecular Weight:
- 553.7
- MDL Number:
- MFCD34568120
- MOL File:
- 931395-42-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Density | 1.36±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | H2O : 50 mg/mL (90.30 mM; Need ultrasonic) |
| form | Solid |
| pka | 13.52±0.20(Predicted) |
| color | White to off-white |
| InChIKey | ZUJBBVJXXYRPFS-DYKIIFRCSA-N |
| SMILES | C(N)(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CCCNC(N)=N)N |
| FDA UNII | IKX7W49NLN |
Serlopitant price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0107857 | Dusquetide 99.96% | 931395-42-5 | 1mg | $87 | 2026-06-04 | Buy |
| ChemScene | CS-0107857 | Dusquetide 99.96% | 931395-42-5 | 5mg | $217 | 2026-06-04 | Buy |
| ChemScene | CS-0107857 | Dusquetide 99.96% | 931395-42-5 | 10mg | $347 | 2026-06-04 | Buy |
| ApexBio Technology | BA1295 | Dusquetide | 931395-42-5 | 1mg | $72 | 2026-05-06 | Buy |
| ApexBio Technology | BA1295 | Dusquetide | 931395-42-5 | 5mg | $180 | 2026-05-06 | Buy |
Serlopitant Chemical Properties, Uses, Production
Uses
Dusquetide (SGX942) is a first-in-class innate defense regulator (IDR). Dusquetide modulates the innate immune response to both PAMPs and DAMPs by binding to p62. Dusquetide shows activity in both reducing inflammation and increasing clearance of bacterial infection[1]. DAMPs: damage-associated molecular patterns; PAMPs: pathogen-associated molecular patterns
in vivo
Dusquetide (SGX942) (25 mg/kg; i.v.; days 0, 4, 7, 10, and 14) shows no increase in tumor growth or worsening of survival and a trend towards decreased tumor growth and improvement in survival with radiation[1].
| Animal Model: | Female nude mice (MCF-7 tumor xenografts)[1] |
| Dosage: | 25 mg/kg |
| Administration: | I.v.; days 0, 4, 7, 10, and 14 |
| Result: | Showed no increase in tumor growth or worsening of survival and a trend towards decreased tumor growth and improvement in survival with radiation. |
References
[1] Kudrimoti M, et al. Dusquetide: A novel innate defense regulator demonstrating a significant and consistent reduction in the duration of oral mucositis in preclinical data and a randomized, placebo-controlled phase 2a clinical study. J Biotechnol. 2016 Dec 10;239:115-125. DOI:10.1016/j.jbiotec.2016.10.010
Serlopitant Preparation Products And Raw materials
Raw materials
Preparation Products
Serlopitant Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Combio (Suzhou) Ltd. | 17751201929; 17751201929 | jianyang_yu@combiosz.com | China | 2989 | 58 |
| Shanghai Biopharmaleader Co., Ltd. | +86 18721201413 | sales@biopharmaleader.com | China | 1711 | 58 |
| Chengdu Youngshe Chemical Co., Ltd. | +86-17380623303 | Caroline@youngshechem.com | China | 4726 | 58 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 15967184799 | Eric@peptidego.com | China | 7872 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Hangzhou Go Top Peptide Biotech | 0571-88211921 17357109671 | sales3@gotopbio.com | China | 2988 | 58 |
| Shaoxing Junyu Biotechnology Co., LTD | 0571-0571-88211921 19105816207 | sales4@gotopbio.com | China | 5135 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Hangzhou Baige Pharmaceutical Technology Co. , Ltd. | 0571-85350119 15888826472 | 15888826472@163.com | China | 2728 | 58 |
| Shanghai HongTide Biotechnology Co.,Ltd. | 15318089928 | alex@hanhonggroup.com | China | 4604 | 58 |
