1-(2-THIAZOLYLAZO)-2-NAPHTHOL
- CAS No.
- 1147-56-4
- Chemical Name:
- 1-(2-THIAZOLYLAZO)-2-NAPHTHOL
- Synonyms
- TAN;ERGi-USU;NSC139021;Nitrilotantalum(III);NSC139021 (ERGi-USU);ERGi-USU (NSC139021);ERGi-USU, 10 mM in DMSO;1-(2’-Thiazolylazo)-β-naphtho;1-(2-THIAZOLYLAZO)-2-NAPHTHOL;1-(thiazol-2-ylazo)-2-naphthol
- CBNumber:
- CB0321974
- Molecular Formula:
- C13H9N3OS
- Molecular Weight:
- 255.3
- MDL Number:
- MFCD00021611
- MOL File:
- 1147-56-4.mol
- MSDS File:
- SDS
| Melting point | 138-139 °C |
|---|---|
| Boiling point | 464.8±47.0 °C(Predicted) |
| Density | 1.40 |
| storage temp. | 2-8°C |
| solubility | methanol: 10 mg/mL, clear |
| form | solid |
| pka | 8.71±0.50(Predicted) |
| color | Red or orange |
| BRN | 223783 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| CAS DataBase Reference | 1147-56-4(CAS DataBase Reference) |
| EPA Substance Registry System | 2-Naphthalenol, 1-(2-thiazolylazo)- (1147-56-4) |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 2927.00.5000 | |||||||||
| NFPA 704 |
|
1-(2-THIAZOLYLAZO)-2-NAPHTHOL price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2906 | ERGi-USU ≥98% (HPLC) | 1147-56-4 | 10 mg | $78.18 | 2025-07-31 | Buy |
| Sigma-Aldrich | SML2906 | ERGi-USU ≥98% (HPLC) | 1147-56-4 | 50 mg | $333 | 2025-07-31 | Buy |
| TCI Chemical | A5003 | TAN [=1-(2-Thiazolylazo)-2-naphthol][Spectrophotometric reagent for transition metals] >99.0%(T) | 1147-56-4 | 1g | $72 | 2025-07-31 | Buy |
| TCI Chemical | A5003 | TAN [=1-(2-Thiazolylazo)-2-naphthol][Spectrophotometric reagent for transition metals] >99.0%(T) | 1147-56-4 | 5g | $246 | 2025-07-31 | Buy |
| Tocris | 6632 | ERGi-USU ≥99%(HPLC) | 1147-56-4 | 50 | $50 | 2021-12-16 | Buy |
1-(2-THIAZOLYLAZO)-2-NAPHTHOL Chemical Properties,Uses,Production
Description
ERGi-USU (1147-56-4) selectively inhibits the growth of ERG-positive VCaP prostate cancer cells, COLO320 colon cancer cells, KG-1 and MOLT-4 leukemia cells with minimal effect on ERG-negative cells or normal prostate or endothelial cells (IC50 = 169 nM for cell growth and 315 nM for ERG protein in VCaP cells). It selectively inhibits the kinase RIOK2 (Kd = 200 nM) causing disruption of ribosomal biogenesis and ribosomal stress.
Uses
1-(2-Thiazolylazo)-2-naphthol is a high affinity Rio Kinase 2 (RIOK2) inhibitor (Kd = 200 nM). Exhibits >6-fold selectivity for RIOK2 over a panel of 456 kinases. Inhibits ERG protein and potently inhibits growth of ERG-positive VCaP prostate cancer cells in vitro (IC50 = 169 nM) but not ERG-negative cell lines. Also inhibits growth of VCaP xenografts in mice.
in vivo
NSC139021 treatment inhibits growth of ERG-positive VCaP tumor xenografts with no apparent toxicity. Significant (P<0.05, P<0.005) inhibition of tumor growth is noted at day 26 in treatment groups indicating 44% (100 mg/kg) and 65% (150 mg/kg) reduction of tumor burden. At 100 mg/kg and 150 mg/kg, no apparent toxicity including weight loss, lethargy, diarrhea, loss of appetite, respiratory distress, or overall drug related toxicity is observed. [1].
storage
Store at +4°C
References
[1] AHMED A MOHAMED. Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth.[J]. Cancer research, 2018: 3659-3671. DOI:10.1158/0008-5472.can-17-2949
1-(2-THIAZOLYLAZO)-2-NAPHTHOL Preparation Products And Raw materials
Raw materials
Preparation Products
1-(2-THIAZOLYLAZO)-2-NAPHTHOL Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 | 1022@dideu.com | China | 3889 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49730 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29804 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32376 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38838 | 58 |
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com | China | 12272 | 58 |
View Lastest Price from 1-(2-THIAZOLYLAZO)-2-NAPHTHOL manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-07-16 | ERGi-USU
1147-56-4
|
US $41.00 / mg | 98% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-05-14 | 1-(2-Thiazolylazo)-2-naphthol
1147-56-4
|
US $0.00 / kg | 20kg | 99% | 20 tons | Qingdao RENAS Polymer Material Co., Ltd. | |
 |
2024-08-17 | 1-(2-THIAZOLYLAZO)-2-NAPHTHOL
1147-56-4
|
US $0.00-0.00 / KG | 1KG | 99.0% | 1000 tons | Shaanxi Dideu Medichem Co. Ltd |
-
- ERGi-USU
1147-56-4
- US $41.00 / mg
- 98%
- TargetMol Chemicals Inc.
-
- 1-(2-Thiazolylazo)-2-naphthol
1147-56-4
- US $0.00 / kg
- 99%
- Qingdao RENAS Polymer Material Co., Ltd.
-
- 1-(2-THIAZOLYLAZO)-2-NAPHTHOL
1147-56-4
- US $0.00-0.00 / KG
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
