5-BROMO-7-INDAZOLECARBOXYLIC ACID METHYL ESTER
- CAS No.
- 898747-24-5
- Chemical Name:
- 5-BROMO-7-INDAZOLECARBOXYLIC ACID METHYL ESTER
- Synonyms
- Methyl 5-bromo-1H-indazole-7-carboxylate;5-Bromo-1H-indazole-7-carboxylic;ethyl 5-broMo-1H-indazole-7-carboxylate;5-Bromo-7-(methoxycarbonyl)-1H-indazole;5-BROMO-7-INDAZOLECARBOXYLIC ACID METHYL ESTER;5-Bromo-1H-indazole-7-carboxylic acid methyl ester;1H-Indazole-7-carboxylic acid, 5-broMo-, Methyl ester
- CBNumber:
- CB0328968
- Molecular Formula:
- C9H7BrN2O2
- Molecular Weight:
- 255.07
- MDL Number:
- MFCD08458991
- MOL File:
- Mol file
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Methyl5-bromo-1H-indazole-7-carboxylate | Y5649 | 250mg | $127 |
| Methyl 5-bromo-1H-indazole-7-carboxylate | 088267 | 1g | $448 |
| 5-BROMO-7-INDAZOLECARBOXYLIC ACID METHYL ESTER 95.00% | HCH0044814 | 5MG | $500.36 |
| methyl5-bromo-1H-indazole-7-carboxylate 98+% | 61-6132 | 0.25g | $600 |
| Methyl5-bromo-1H-indazole-7-carboxylate 98% | A130469 | 25g | $1025 |
| More product size | |||
| Boiling point | 395.9±22.0 °C(Predicted) |
|---|---|
| Density | 1.709±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 10.67±0.40(Predicted) |
| Appearance | Off-white to yellow Solid |
| InChI | InChI=1S/C9H7BrN2O2/c1-14-9(13)7-3-6(10)2-5-4-11-12-8(5)7/h2-4H,1H3,(H,11,12) |
| InChIKey | QQXHHJBRURQNLO-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=C(Br)C=C2C(OC)=O)C=N1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332 |
| Precautionary statements | P260-P280-P312 |
| RIDADR | 2811 |
| HazardClass | 6.1 |
| PackingGroup | Ⅲ |
| HS Code | 2933998090 |
5-BROMO-7-INDAZOLECARBOXYLIC ACID METHYL ESTER price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AK Scientific | Y5649 | Methyl5-bromo-1H-indazole-7-carboxylate | 898747-24-5 | 250mg | $127 | 2021-12-16 | Buy |
| Matrix Scientific | 088267 | Methyl 5-bromo-1H-indazole-7-carboxylate | 898747-24-5 | 1g | $448 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0044814 | 5-BROMO-7-INDAZOLECARBOXYLIC ACID METHYL ESTER 95.00% | 898747-24-5 | 5MG | $500.36 | 2021-12-16 | Buy |
| Abosyn | 61-6132 | methyl5-bromo-1H-indazole-7-carboxylate 98+% | 898747-24-5 | 0.25g | $600 | 2021-12-16 | Buy |
| Ambeed | A130469 | Methyl5-bromo-1H-indazole-7-carboxylate 98% | 898747-24-5 | 25g | $1025 | 2021-12-16 | Buy |
5-BROMO-7-INDAZOLECARBOXYLIC ACID METHYL ESTER Chemical Properties,Uses,Production
Synthesis
206548-14-3
898747-24-5
Methyl 2-amino-5-bromo-3-methylbenzoate (19-S3, 10.9 g, 44.7 mmol) and potassium acetate (AcOK, 1.32 g, 13.41 mmol) were dissolved in dichloromethane (CH2Cl2, 50 mL) under nitrogen protection and cooled to 0 °C. Acetic anhydride (Ac2O, 10.6 g, 103 mmol) was added slowly and the reaction mixture was stirred at room temperature for 1 hour. Subsequently, the mixture was heated to 60 °C and tert-butyl nitrite (t-BuONO, 10.2 g, 98.3 mmol) was added. The resulting mixture was continued to be stirred at 60 °C for 4 hours. After completion of the reaction, it was cooled to room temperature, the reaction was quenched with saturated aqueous sodium bicarbonate (NaHCO3) and extracted with ethyl acetate (EtOAc). The organic layer was separated, dried over anhydrous sodium sulfate and concentrated to give the crude product. The crude product was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate=100:0 to 10:1) to afford methyl 5-bromo-1H-indazole-7-carboxylate (19-S4, 8.0 g, 70.5% yield) as a yellow solid. lc-MS (ESI) m/z: 255 (M+H).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 11, p. 2578 - 2581
[2] Patent: WO2018/160889, 2018, A1. Location in patent: Page/Page column 474; 475
[3] Patent: WO2015/157093, 2015, A1. Location in patent: Paragraph 0394
[4] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 3, p. 1156 - 1162
[5] Patent: WO2008/65508, 2008, A1
5-BROMO-7-INDAZOLECARBOXYLIC ACID METHYL ESTER Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29798 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Shanxi Xuanran Import and Export Trade Co., Ltd. | +8617735180244 | mike_yan@xuanranglobal.com | CHINA | 4017 | 58 |
| CR Corporation Limited | +8613062833949 | fred.wen@crcorporation.cn | China | 8645 | 58 |
| Nanjing Hengbei Chemicals Co., Ltd. | +86-25-58393656 | sales@hengbeichem.cn | China | 6854 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 24727 | 58 |
View Lastest Price from 5-BROMO-7-INDAZOLECARBOXYLIC ACID METHYL ESTER manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2020-01-13 | 5-BROMO-7-INDAZOLECARBOXYLIC ACID METHYL ESTER
898747-24-5
|
US $6.68 / KG | 1KG | 97%-99% | 1kg-1000kg | Career Henan Chemical Co |
-
- 5-BROMO-7-INDAZOLECARBOXYLIC ACID METHYL ESTER
898747-24-5
- US $6.68 / KG
- 97%-99%
- Career Henan Chemical Co
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