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L-Phenylalanine benzyl ester hydrochloride

L-Phenylalanine benzyl ester hydrochloride structure

CAS No.: 2462-32-0

Chemical Name:: L-Phenylalanine benzyl ester hydrochloride

Synonyms: L-Phenylalanine Benzyl Ester HCl;PHE-OBZL HCL;H-PHE-OBZL HCL;H-PHE-OBZL.HCI;Nsc522226;anine BenzyL;H-PHE-OBZL·HCL;H-L-Phe-OBzl*HCl;PHENYLALANINE-OBZL HCL;H-Phe-OBzl hydrochloride

CBNumber:: CB0330248

Molecular Formula:: C16H18ClNO2

Molecular Weight:: 291.77

MDL Number:: MFCD00043249

MOL File:: 2462-32-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 22:38:04

Product description	Number	Pack Size	Price
L-Phenylalanine benzyl ester hydrochloride ≥99.0% (AT)	78060	5g	$104
L-Phenylalanine Benzyl Ester Hydrochloride >98.0%(HPLC)(N)	P1718	5g	$31
L-Phenylalanine Benzyl Ester Hydrochloride >98.0%(HPLC)(N)	P1718	25g	$125
L-Phenylalanine benzyl ester hydrochloride Asreported	287765	10g	$333
L-Phenylalanine benzyl ester hydrochloride Asreported	287765	25g	$502
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L-Phenylalanine benzyl ester hydrochloride Properties

Melting point	197-200 °C
alpha	-13 º (c=1% in 80% acetic acid)
refractive index	-12 ° (C=1, 80% acetic acid)
storage temp.	Inert atmosphere,Room Temperature
Water Solubility	Soluble in water
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form	Crystalline Powder
color	White to off-white
optical activity	[α]20/D 13±1°, c = 1% in acetic acid: water (4:1)
BRN	3919200
Major Application	peptide synthesis
InChI	InChI=1/C16H17NO2.ClH/c17-15(11-13-7-3-1-4-8-13)16(18)19-12-14-9-5-2-6-10-14;/h1-10,15H,11-12,17H2;1H/t15-;/s3
InChIKey	CEXFHIYDTRNBJD-AVAJOTNLNA-N
SMILES	C1(=CC=CC=C1)C[C@H](N)C(=O)OCC1C=CC=CC=1.Cl \|&1:7,r\|
CAS DataBase Reference	2462-32-0(CAS DataBase Reference)
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P301+P312-P302+P352-P304+P340-P305+P351+P338

PPE

Eyeshields, Gloves, type N95 (US)

Safety Statements

22-24/25

WGK Germany

HS Code

29224999

Storage Class

11 - Combustible Solids

NFPA 704

	1
1		1

L-Phenylalanine benzyl ester hydrochloride price More Price(70)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	78060	L-Phenylalanine benzyl ester hydrochloride ≥99.0% (AT)	2462-32-0	5g	$104	2026-04-30	Buy
TCI Chemical	P1718	L-Phenylalanine Benzyl Ester Hydrochloride >98.0%(HPLC)(N)	2462-32-0	5g	$31	2026-04-30	Buy
TCI Chemical	P1718	L-Phenylalanine Benzyl Ester Hydrochloride >98.0%(HPLC)(N)	2462-32-0	25g	$125	2026-04-30	Buy
Usbiological	287765	L-Phenylalanine benzyl ester hydrochloride Asreported	2462-32-0	10g	$333	2026-06-03	Buy
Usbiological	287765	L-Phenylalanine benzyl ester hydrochloride Asreported	2462-32-0	25g	$502	2026-06-03	Buy

Product number	Packaging	Price	Buy
78060	5g	$104	Buy
P1718	5g	$31	Buy
P1718	25g	$125	Buy
287765	10g	$333	Buy
287765	25g	$502	Buy

L-Phenylalanine benzyl ester hydrochloride Chemical Properties,Uses,Production

Chemical Properties

White crystal

Uses

L-Phenylalanine Benzyl Ester Hydrochloride is a commonly used reactant for the synthesis of L-isoserine derivatives as aminopeptidase N inhibitors and PF-04449913 as a potent and orally bioavailable inhibitor of smoothened.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

66617-58-1

2462-32-0

The general procedure for the synthesis of L-phenylalanine benzyl ester hydrochloride from (S)-benzyl 2-((tert-butoxycarbonyl)amino)-3-phenylpropionate was as follows: benzyl (2S)-2-(tert-butoxycarbonylamino)-3-phenylpropionate (12.8 g, 36 mmol) was dissolved in an ether solution of 2 M HCl (90 mL) and a dioxane solution of 4 M HCl (18 mL). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the mixture was diluted with hexane (100 mL) and subsequently filtered to afford L-phenylalanine benzyl ester hydrochloride (7.98 g, 76% yield) as a white fine powder. The product was characterized by 1H NMR (CD3OD, 400 MHz): δ (ppm) 7.40-7.15 (m, 10H), 5.23 (s, 2H), 4.36-4.31 (m, 1H), 3.26-3.12 (m, 2H).

References

[1] Journal of Organic Chemistry, 2015, vol. 80, # 9, p. 4235 - 4243
[2] Patent: US9441012, 2016, B2. Location in patent: Page/Page column 67
[3] Bioorganic and Medicinal Chemistry Letters, 2000, vol. 10, # 14, p. 1497 - 1499
[4] Journal of Enzyme Inhibition and Medicinal Chemistry, 2012, vol. 27, # 2, p. 302 - 310
[5] Chemistry - A European Journal, 2012, vol. 18, # 21, p. 6528 - 6541

L-Phenylalanine benzyl ester hydrochloride Preparation Products And Raw materials

Raw materials

BOC-PHE-OBZL Diethyl ether Hydrochloric acid 1,4-Dioxane

Preparation Products

L-Phenylalanine benzyl ester hydrochloride Suppliers

Global( 280)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
Sichuan HongRi Pharma-Tech Co.,Ltd	+8618382028708	ni@enlaibio.com	China	1103	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	sales@amoychem.com	China	6366	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9636	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-0519-85551759 +8613506123987	marketing1@neostarunited.com	China	8828	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Sichuan HongRi Pharma-Tech Co.,Ltd	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Xiamen AmoyChem Co., Ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Antai Fine Chemical Technology Co.,Limited	58
Neostar United (Changzhou) Industrial Co., Ltd.	58

View Lastest Price from L-Phenylalanine benzyl ester hydrochloride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-06-12	H-L-Phe-OBzl.HCl 2462-32-0		1kg	98%	1T+	Sichuan HongRi Pharma-Tech Co.,Ltd
2025-06-27	L-Phenylalanine benzyl ester hydrochloride 2462-32-0	$10.00-30.00	50KG	99%	500000kg	Hebei Chuanghai Biotechnology Co., Ltd
2021-08-12	L-Phenylalanine benzyl ester hydrochloride 2462-32-0	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd

H-L-Phe-OBzl.HCl
2462-32-0
98%
Sichuan HongRi Pharma-Tech Co.,Ltd

L-Phenylalanine benzyl ester hydrochloride
2462-32-0
$10.00-30.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

L-Phenylalanine benzyl ester hydrochloride
2462-32-0
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

L-Phenylalanine benzyl ester hydrochloride Spectrum

L-Phenylalanine benzyl ester hydrochloride(2462-32-0)MS L-Phenylalanine benzyl ester hydrochloride(2462-32-0)¹HNMR L-Phenylalanine benzyl ester hydrochloride(2462-32-0)IR1 L-Phenylalanine benzyl ester hydrochloride(2462-32-0)IR2

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benzyl 3-phenyl-L-alaninate hydrochloride H-PHE-OBZL·HCL L-Phenylalanine benzyl ester hydrochloride≥ 99% (HPLC) PHENYLALANINE-OBZL HCL L-PHENYLALANINE BENZYL ESTER HYDROCHLORIDE L-PHENYLALANINE BENZYL ESTER HYDROCHLORIDE SALT H-L-Phe-OBzl*HCl Nsc522226 l-phenylalanine benzyl ester hydrovhloride H-Phe-OBzl hydrochloride benzyl (2S)-2-aMino-3-phenylpropanoate hydrochloride (S)-benzyl 2-aMino-3-phenylpropanoate hydrochloride Phenylalanine, benzyl ester hydrochloride L-PhenylalanineBenzylEsterHydrochloride> anine BenzyL L-Phenylalanine, phenylmethyl ester, hydrochloride (1:1) L-Phenylalanine benzyl ester hydrochloride USP/EP/BP L-Phenylalanine Benzyl Ester Hydrochloride extrapure, 99% L-Phenylalanine benzyl ester hydrochloride L-Phenylalanine benzyl ester hydrochloride 99% H-PHE-OBZL HCL H-PHE-OBZL.HCI L-Phenylalanine Benzyl Ester HCl PHE-OBZL HCL 2462-32-0 462-32-0 2462-30-0 C16H17NO2ClH C6H5CH2CHNH2COOCH2C6H5HCl C16H17NO2HCl C6H17NO2HCl Amino Acid Derivatives Phenylalanine Peptide Synthesis Specialty Synthesis Phenylalanine [Phe, F] Amino Acids and Derivatives Amino Acid Benzyl Esters Amino Acids (C-Protected) Biochemistry Amino hydrochloride Amino Acid Derivatives Peptide Synthesis Phenylalanine Amino Acid Derivatives Amino Acids