L-Phenylalanine benzyl ester hydrochloride
- CAS No.
- 2462-32-0
- Chemical Name:
- L-Phenylalanine benzyl ester hydrochloride
- Synonyms
- L-Phenylalanine Benzyl Ester HCl;Nsc522226;PHE-OBZL HCL;anine BenzyL;H-PHE-OBZL HCL;H-PHE-OBZL.HCI;H-PHE-OBZL·HCL;H-L-Phe-OBzl*HCl;PHENYLALANINE-OBZL HCL;H-Phe-OBzl hydrochloride
- CBNumber:
- CB0330248
- Molecular Formula:
- C16H18ClNO2
- Molecular Weight:
- 291.77
- MDL Number:
- MFCD00043249
- MOL File:
- 2462-32-0.mol
- MSDS File:
- SDS
| Melting point | 197-200 °C |
|---|---|
| alpha | -13 º (c=1% in 80% acetic acid) |
| refractive index | -12 ° (C=1, 80% acetic acid) |
| storage temp. | Inert atmosphere,Room Temperature |
| Water Solubility | Soluble in water |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| form | Crystalline Powder |
| color | White to off-white |
| optical activity | [α]20/D 13±1°, c = 1% in acetic acid: water (4:1) |
| BRN | 3919200 |
| InChI | InChI=1/C16H17NO2.ClH/c17-15(11-13-7-3-1-4-8-13)16(18)19-12-14-9-5-2-6-10-14;/h1-10,15H,11-12,17H2;1H/t15-;/s3 |
| InChIKey | CEXFHIYDTRNBJD-AVAJOTNLNA-N |
| SMILES | C1(=CC=CC=C1)C[C@H](N)C(=O)OCC1C=CC=CC=1.Cl |&1:7,r| |
| CAS DataBase Reference | 2462-32-0(CAS DataBase Reference) |
| UNSPSC Code | 12352209 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Safety Statements | 22-24/25 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| WGK Germany | 3 | |||||||||
| HS Code | 29224999 | |||||||||
| NFPA 704 |
|
L-Phenylalanine benzyl ester hydrochloride price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 78060 | L-Phenylalanine benzyl ester hydrochloride ≥99.0% (AT) | 2462-32-0 | 5g | $68.67 | 2025-07-31 | Buy |
| TCI Chemical | P1718 | L-Phenylalanine Benzyl Ester Hydrochloride >98.0%(HPLC)(N) | 2462-32-0 | 5g | $31 | 2025-07-31 | Buy |
| TCI Chemical | P1718 | L-Phenylalanine Benzyl Ester Hydrochloride >98.0%(HPLC)(N) | 2462-32-0 | 25g | $125 | 2025-07-31 | Buy |
| Usbiological | 239373 | L-Phenylalanine benzyl ester hydrochloride | 2462-32-0 | 5g | $170 | 2021-12-16 | Buy |
| TRC | P319445 | L-Phenylalanine Benzyl Ester Hydrochloride | 2462-32-0 | 5g | $70 | 2021-12-16 | Buy |
L-Phenylalanine benzyl ester hydrochloride Chemical Properties,Uses,Production
Chemical Properties
White crystal
Uses
L-Phenylalanine Benzyl Ester Hydrochloride is a commonly used reactant for the synthesis of L-isoserine derivatives as aminopeptidase N inhibitors and PF-04449913 as a potent and orally bioavailable inhibitor of smoothened.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
66617-58-1
2462-32-0
The general procedure for the synthesis of L-phenylalanine benzyl ester hydrochloride from (S)-benzyl 2-((tert-butoxycarbonyl)amino)-3-phenylpropionate was as follows: benzyl (2S)-2-(tert-butoxycarbonylamino)-3-phenylpropionate (12.8 g, 36 mmol) was dissolved in an ether solution of 2 M HCl (90 mL) and a dioxane solution of 4 M HCl (18 mL). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the mixture was diluted with hexane (100 mL) and subsequently filtered to afford L-phenylalanine benzyl ester hydrochloride (7.98 g, 76% yield) as a white fine powder. The product was characterized by 1H NMR (CD3OD, 400 MHz): δ (ppm) 7.40-7.15 (m, 10H), 5.23 (s, 2H), 4.36-4.31 (m, 1H), 3.26-3.12 (m, 2H).
References
[1] Journal of Organic Chemistry, 2015, vol. 80, # 9, p. 4235 - 4243
[2] Patent: US9441012, 2016, B2. Location in patent: Page/Page column 67
[3] Bioorganic and Medicinal Chemistry Letters, 2000, vol. 10, # 14, p. 1497 - 1499
[4] Journal of Enzyme Inhibition and Medicinal Chemistry, 2012, vol. 27, # 2, p. 302 - 310
[5] Chemistry - A European Journal, 2012, vol. 18, # 21, p. 6528 - 6541
L-Phenylalanine benzyl ester hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mujin Biotechnology Co.,Ltd | +8613288715578 | sales@hbmojin.com | China | 12300 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Sichuan HongRi Pharma-Tech Co.,Ltd | +8617390183901 | cynthia@enlaibio.com | China | 1100 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29734 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6369 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
View Lastest Price from L-Phenylalanine benzyl ester hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-22 | H-L-Phe-OBzl.HCl
2462-32-0
|
US $0.00-0.00 / kg | 1kg | 98% | 1T+ | Sichuan HongRi Pharma-Tech Co.,Ltd | |
 |
2025-08-08 | L-Phenylalanine benzyl ester hydrochloride
2462-32-0
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mujin Biotechnology Co.,Ltd | |
 |
2025-06-27 | L-Phenylalanine benzyl ester hydrochloride
2462-32-0
|
US $30.00-10.00 / KG | 50KG | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd |
-
- H-L-Phe-OBzl.HCl
2462-32-0
- US $0.00-0.00 / kg
- 98%
- Sichuan HongRi Pharma-Tech Co.,Ltd
-
- L-Phenylalanine benzyl ester hydrochloride
2462-32-0
- US $0.00 / KG
- 99%
- Hebei Mujin Biotechnology Co.,Ltd
-
- L-Phenylalanine benzyl ester hydrochloride
2462-32-0
- US $30.00-10.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
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