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Methyltetrazine-NHS Ester

CAS No.
1644644-96-1
Chemical Name:
Methyltetrazine-NHS Ester
Synonyms
Methyltetrazine-Ph-NHS ester;2,5-dioxopyrrolidin-1-yl 2-(4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl)acetate;Methyltetrazine-NHS Ester;Methyltetrazine-PAA-NHS Ester;Methyltetrazine-NHS ester >=95%;Methyltetrazine-NHS Ester (CCT-1128);2,5-Dioxo-1-pyrrolidinyl 2-[4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenyl]acetate;2,5-dioxypyrolidine-1-yl2-(4-(6-methyl-1,2,4,5-tetrazine-3-yl)phenyl)acetic acidester;Benzeneacetic acid, 4-(6-methyl-1,2,4,5-tetrazin-3-yl)-, 2,5-dioxo-1-pyrrolidinyl ester
CBNumber:
CB03345049
Molecular Formula:
C15H13N5O4
Molecular Weight:
327.29
MDL Number:
MFCD28334557
MOL File:
1644644-96-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-16 07:06:08

Methyltetrazine-NHS Ester Properties

Boiling point 563.1±60.0 °C(Predicted)
Density 1.48±0.1 g/cm3(Predicted)
storage temp. -20°C
pka 1.37±0.10(Predicted)
form Solid
color Purple to purplish red
InChI 1S/C15H13N5O4/c1-9-16-18-15(19-17-9)11-4-2-10(3-5-11)8-14(23)24-20-12(21)6-7-13(20)22/h2-5H,6-8H2,1H3
InChIKey BIHJLZOOHNOUCG-UHFFFAOYSA-N
SMILES O=C(ON1C(CCC1=O)=O)CC(C=C2)=CC=C2C3=NN=C(C)N=N3
UNSPSC Code 12352108
NACRES NA.22

SAFETY

Risk and Safety Statements

WGK Germany  WGK 3
Storage Class 11 - Combustible Solids

Methyltetrazine-NHS Ester price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 900914 Methyltetrazine-NHS ester ≥95% 1644644-96-1 100MG $289 2026-04-30 Buy
TCI Chemical M3494 Methyltetrazine-NHS Ester 1644644-96-1 25MG $110 2026-04-30 Buy
Biosynth UQC64496 Methyltetrazine-NHS ester 1644644-96-1 0.5g $649 2026-06-05 Buy
Biosynth UQC64496 Methyltetrazine-NHS ester 1644644-96-1 1g $1038.4 2026-06-05 Buy
Biosynth UQC64496 Methyltetrazine-NHS ester 1644644-96-1 2g $1687.4 2026-06-05 Buy
Product number Packaging Price Buy
900914 100MG $289 Buy
M3494 25MG $110 Buy
UQC64496 0.5g $649 Buy
UQC64496 1g $1038.4 Buy
UQC64496 2g $1687.4 Buy

Methyltetrazine-NHS Ester Chemical Properties,Uses,Production

Description

Methyltetrazine-NHS Ester is a NHS actived building block containing a methyltetrazine group. It can react with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic pH to form covalent bonds. Methyltetrazine enable fast click reaction with TCO (trans-cycloctene).

Uses

Methyltetrazine-NHS ester has an N-hydroxysuccinimide (NHS) ester that can be reacted with primary amines and a methyltetrazine, which is reactive to trans-cyclooctenes. The NHS ester reacts with primary amines (e.g. side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic pH to form covalent bonds. The short spacer arm adds minimal mass to modified molecules (230.2 daltons). It is generally used in click chemistry applications in bioconjugate chemistry.

reaction suitability

reaction type: click chemistry
reagent type: cross-linking reagent

IC 50

Alkyl/ether

Methyltetrazine-NHS Ester Preparation Products And Raw materials

Raw materials

Preparation Products

Methyltetrazine-NHS Ester Suppliers

Global( 69)Suppliers
Supplier Tel Email Country ProdList Advantage
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51389 80
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd 0431-80534353 19917294565 et@chemextension.com China 3904 55
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8000 62
Jinan elephant international trading co., LTD 13006575422@163.com China 6347 58
Zhengzhou Huiju Chemical Co., Ltd. 0371-55900031 18137872243 3927209986@qq.com China 9997 55
Aikon International Limited 025-58859352 13913916777 dt3@aikonchem.com China 15490 58
Xi'an Confluore Biological Technology Co., Ltd. +86-156-80926068 +86-15680926068 1924344760@qq.com China 4229 58
Henan's chemical products co., LTD 0371-60919097 15378766539; 794449696@qq.com China 4990 58

View Lastest Price from Methyltetrazine-NHS Ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Methyltetrazine-Ph-NHS ester pictures 2026-07-15 Methyltetrazine-Ph-NHS ester
1644644-96-1
10g TargetMol Chemicals Inc.
Methyltetrazine-NHS ester pictures 2025-06-07 Methyltetrazine-NHS ester
1644644-96-1
100mg >99.00% 1g Xian confluore Biological Technology Co., Ltd.

Methyltetrazine-NHS Ester Spectrum

Methyltetrazine-NHS Ester Methyltetrazine-NHS ester >=95% Benzeneacetic acid, 4-(6-methyl-1,2,4,5-tetrazin-3-yl)-, 2,5-dioxo-1-pyrrolidinyl ester Methyltetrazine-NHS Ester (CCT-1128) 2,5-Dioxo-1-pyrrolidinyl 2-[4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenyl]acetate 2,5-dioxypyrolidine-1-yl2-(4-(6-methyl-1,2,4,5-tetrazine-3-yl)phenyl)acetic acidester Methyltetrazine-PAA-NHS Ester 2,5-dioxopyrrolidin-1-yl 2-(4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl)acetate Methyltetrazine-Ph-NHS ester 1644644-96-1