sodium:(5Z)-5-[(4-pyridin-4-ylquinolin-6-yl)methylidene]-1,3-thiazolidin-3-ide-2,4-dione:hydrate
![sodium:(5Z)-5-[(4-pyridin-4-ylquinolin-6-yl)methylidene]-1,3-thiazolidin-3-ide-2,4-dione:hydrate Structure](CAS/20180527/GIF/1356195-42-0.gif)
- CAS No.
- 1356195-42-0
- Chemical Name:
- sodium:(5Z)-5-[(4-pyridin-4-ylquinolin-6-yl)methylidene]-1,3-thiazolidin-3-ide-2,4-dione:hydrate
- Synonyms
- sodium:(5Z)-5-[(4-pyridin-4-ylquinolin-6-yl)methylidene]-1,3-thiazolidin-3-ide-2,4-dione:hydrate
- CBNumber:
- CB03400809
- Molecular Formula:
- C18H10N3O2S.H2O.Na
- Molecular Weight:
- 373.36
- MDL Number:
- MOL File:
- 1356195-42-0.mol
- MSDS File:
- SDS
sodium:(5Z)-5-[(4-pyridin-4-ylquinolin-6-yl)methylidene]-1,3-thiazolidin-3-ide-2,4-dione:hydrate Properties
| storage temp. | 2-8°C |
|---|---|
| solubility | soluble in DMSO, Methanol |
| form | Solid |
| color | Pale Yellow |
| Water Solubility | H2O: ≥8mg/mL |
| InChI | 1S/C18H11N3O2S.Na.H2O/c22-17-16(24-18(23)21-17)10-11-1-2-15-14(9-11)13(5-8-20-15)12-3-6-19-7-4-12;;/h1-10H,(H,21,22,23);;1H2/q;+1;/p-1/b16-10-;; |
| InChIKey | KKSRFFGUIONCPS-FLPKAINGSA-M |
| SMILES | O.[Na+].O=C1[N-]C(=O)C(\S1)=C\c2ccc3nccc(-c4ccncc4)c3c2 |
| UNSPSC Code | 12352203 |
| NACRES | NA.44 |
sodium:(5Z)-5-[(4-pyridin-4-ylquinolin-6-yl)methylidene]-1,3-thiazolidin-3-ide-2,4-dione:hydrate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0083 | GSK 1059615 sodium salt hydrate | 1356195-42-0 | 10 mg | $131 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML0083 | GSK 1059615 sodium salt hydrate | 1356195-42-0 | 50 mg | $539 | 2026-04-30 | Buy |
| Usbiological | 012980 | GSK 1059615 | 1356195-42-0 | 10mg | $446 | 2026-06-03 | Buy |
| TRC | G797450 | GSK 1059615 sodium salt hydrate | 1356195-42-0 | 100mg | $1110 | 2021-12-16 | Buy |
sodium:(5Z)-5-[(4-pyridin-4-ylquinolin-6-yl)methylidene]-1,3-thiazolidin-3-ide-2,4-dione:hydrate Chemical Properties,Uses,Production
Uses
GSK 1059615 is a potent inhibitor of PI 3-kinase α (PI3Kα). GSK 1059615 inhibits proliferation in BT474 cells and attenuates MAPK signaling.
Biological Activity
GSK 1059615 is a phosphatidylinositol-3-kinases (PI3K) inhibitor. GSK 1059615 inhibits proliferation of breast cancer BT474 cells via four different mechanisms th at include retinoblastoma 1 (RB1)-mediated cell cycle arrest, elevated forkhead box protein O1 (FOXO) signaling, deduced MYC and transferrin receptor (TFRC) signaling and decreased cellular metabolism. Additionally, GSK 1059615 can suppress cell proliferation by decreasing mitogen-activated protein kinase (MAPK) signaling and imparts sensitivity to phosphoinositide 3-kinase (PI3K) inhibitor in cells resistant to the protein kinase B or AKT inhibitor. GSK 1059615 functions as a druggable target to reduce radiation-induced apoptosis in NCCIT cells. GSK 1059615 has entered clinical trial in patients with solid tumors or lymphoma and refractory malignancies.', 'GSK 1059615 is a potent inhibitor of PI3 Kinase. (IC50 = 2 nM)
sodium:(5Z)-5-[(4-pyridin-4-ylquinolin-6-yl)methylidene]-1,3-thiazolidin-3-ide-2,4-dione:hydrate Preparation Products And Raw materials
Raw materials
Preparation Products
sodium:(5Z)-5-[(4-pyridin-4-ylquinolin-6-yl)methylidene]-1,3-thiazolidin-3-ide-2,4-dione:hydrate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1246 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| Supplier | Advantage |
|---|---|
| Beijing Biocreative Technology Co., Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
View Lastest Price from sodium:(5Z)-5-[(4-pyridin-4-ylquinolin-6-yl)methylidene]-1,3-thiazolidin-3-ide-2,4-dione:hydrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | GSK-1059615 sodium salt hydrate
1356195-42-0
|
$1520.00-2500.00 | 10g | TargetMol Chemicals Inc. |
-
- GSK-1059615 sodium salt hydrate
1356195-42-0
- $1520.00-2500.00
- TargetMol Chemicals Inc.
