5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE
- CAS No.
- 39974-94-2
- Chemical Name:
- 5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE
- Synonyms
- 5-METHOXY-1-METHYL-1H-INDOLE-3-CARBALDEHYDE;AKOS JY2082772;3-Formyl-5-methoxy-1-methylindole;3-Formyl-5-methoxy-1-methyl-1H-indole;5-methoxy-1-methylindole-3-carbaldehyde;5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE;5-METHOXY-1-METHYL-1H-INDOLE-3-CARBALDEHYD;5-Methoxy-1-methyl-1H-indole-3-carboxaldehyde;1H-Indole-3-carboxaldehyde, 5-methoxy-1-methyl-
- CBNumber:
- CB0343873
- Molecular Formula:
- C11H11NO2
- Molecular Weight:
- 189.21
- MDL Number:
- MFCD01578324
- MOL File:
- 39974-94-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 5-Methoxy-1-methyl-1H-indole-3-carbaldehyde | FM117680 | 100mg | $150 |
| 5-Methoxy-1-methyl-1H-indole-3-carbaldehyde | FM117680 | 250mg | $227.5 |
| 5-Methoxy-1-methyl-1H-indole-3-carbaldehyde | FM117680 | 500mg | $360 |
| 5-Methoxy-1-methyl-1H-indole-3-carbaldehyde | FM117680 | 1000mg | $540 |
| 5-Methoxy-1-methyl-1H-indole-3-carbaldehyde | FM117680 | 2000mg | $900 |
| More product size | |||
| Melting point | 133-136°C |
|---|---|
| Boiling point | 357.9±22.0 °C(Predicted) |
| Density | 1.14±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | solid |
| color | Brown |
| Water Solubility | It is insoluble in water. |
| Sensitive | Air Sensitive |
| BRN | 1528827 |
| CAS DataBase Reference | 39974-94-2 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 36/37/38-22 | |||||||||
| Safety Statements | 26-36 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2933998090 | |||||||||
| NFPA 704 |
|
5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FM117680 | 5-Methoxy-1-methyl-1H-indole-3-carbaldehyde | 39974-94-2 | 100mg | $150 | 2026-06-04 | Buy |
| Biosynth | FM117680 | 5-Methoxy-1-methyl-1H-indole-3-carbaldehyde | 39974-94-2 | 250mg | $227.5 | 2026-06-04 | Buy |
| Biosynth | FM117680 | 5-Methoxy-1-methyl-1H-indole-3-carbaldehyde | 39974-94-2 | 500mg | $360 | 2026-06-04 | Buy |
| Biosynth | FM117680 | 5-Methoxy-1-methyl-1H-indole-3-carbaldehyde | 39974-94-2 | 1000mg | $540 | 2026-06-04 | Buy |
| Biosynth | FM117680 | 5-Methoxy-1-methyl-1H-indole-3-carbaldehyde | 39974-94-2 | 2000mg | $900 | 2026-06-04 | Buy |
5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE Chemical Properties,Uses,Production
Uses
5-Methoxy-1-methylindole-3-carboxaldehyde is used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.
Synthesis
10601-19-1
74-88-4
39974-94-2
1. 5-methoxyindole-3-carboxaldehyde (300 mg, 1.71 mmol) was added to a stirring solution of sodium hydride suspension (82 mg, 2.05 mmol, 60% dispersed in mineral oil) in DMF (8 mL) in batches under argon protection, a process which needed to be completed within 5 minutes. 2. The reaction mixture was continued to be stirred for 30 minutes, followed by the addition of iodomethane (0.13 mL, 2.05 mmol) and continued stirring for 1 hour. 3. Upon completion of the reaction, 10% sodium bicarbonate solution (40 mL) was added and the mixture was extracted with ethyl acetate (4×). 4. The organic layers were combined, washed sequentially with 10% sodium bicarbonate solution (2×) and saturated sodium chloride solution, dried over anhydrous magnesium sulfate, filtered and concentrated. 5. The crude product was purified by column chromatography (eluent: 50:50 ethyl acetate/hexane) to afford 5-methoxy-1-methylindole-3-carbaldehyde (320 mg, 99%) as a light yellow solid. Rf = 0.35 (50:50 ethyl acetate/hexane); melting point = 130-132°C (literature value: 132-133°C). 1H NMR (CDCl3): δ 9.95 (s, 1H), 7.79 (d, 1H, J = 2.4 Hz), 7.62 (s, 1H), 7.25 (d, 1H, J = 8.8 Hz), 6.96 (dd, 1H, J = 2.4 and 8.9 Hz), 3.90 (s, 3H), 3.85 (s, 3H).
References
[1] Tetrahedron, 2005, vol. 61, # 7, p. 1793 - 1801
[2] Organic Letters, 2013, vol. 15, # 11, p. 2636 - 2639
[3] Patent: US2003/8850, 2003, A1
[4] Journal of Medicinal Chemistry, 2018, vol. 61, # 14, p. 6261 - 6276
[5] Chemical Biology and Drug Design, 2015, vol. 86, # 4, p. 731 - 745
5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52704 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49923 | 58 |
| XIAMEN AMITY INDUSTRY AND TRADE CO., LTD. | +8618950047208 | ellena@amitychem.com | China | 43414 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131956 | 58 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30123 | 84 |
View Lastest Price from 5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2020-01-15 | 5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE
39974-94-2
|
$1.00 | 1KG | 99% | 100JKG | Career Henan Chemical Co |
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- 5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE
39974-94-2
- $1.00
- 99%
- Career Henan Chemical Co
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