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2-(Cyanomethyl)benzimidazole

2-(Cyanomethyl)benzimidazole structure

CAS No.: 4414-88-4

Chemical Name:: 2-(Cyanomethyl)benzimidazole

Synonyms: 2-(1H-benzo[d]imidazol-2-yl)acetonitrile;1h-benzimidazole-2-acetonitrile;AKOS BC-1506;96.0%(GC&AURORA KA-5429;IFLAB-BB F0266-2601;LABOTEST-BB LT00159463;2-kyanmethylbenzimidazol;CYANOMETHYLBENZIMIDAZOLE;2-cyanomethyl-benzimidazol

CBNumber:: CB0351933

Molecular Formula:: C9H7N3

Molecular Weight:: 157.17

MDL Number:: MFCD00005601

MOL File:: 4414-88-4.mol

MSDS File:: SDS

Last updated:2026-01-13 11:13:02

Product description	Number	Pack Size	Price
(2-Benzimidazolyl)acetonitrile 97%	B5291	10g	$97.2
(2-Benzimidazolyl)acetonitrile >96.0%(GC)(T)	B2821	5g	$44
(2-Benzimidazolyl)acetonitrile >96.0%(GC)(T)	B2821	25g	$151
2-(Cyanomethyl)benzimidazole	C990120	100mg	$45
2-(Cyanomethyl)benzimidazole	C990120	500mg	$65
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2-(Cyanomethyl)benzimidazole Properties

Melting point	200-205 °C (dec.)(lit.)
Boiling point	271.83°C (rough estimate)
Density	1.2279 (rough estimate)
refractive index	1.5330 (estimate)
storage temp.	Sealed in dry,Room Temperature
pka	11.01±0.10(Predicted)
form	powder to crystal
color	White to Brown
Water Solubility	Insoluble in water.
BRN	128461
Cosmetics Ingredients Functions	HAIR DYEING
InChI	1S/C9H7N3/c10-6-5-9-11-7-3-1-2-4-8(7)12-9/h1-4H,5H2,(H,11,12)
InChIKey	BWOVACANEIVHST-UHFFFAOYSA-N
SMILES	N#CCc1nc2ccccc2[nH]1
CAS DataBase Reference	4414-88-4(CAS DataBase Reference)
FDA UNII	0AN9A7OY6F
EPA Substance Registry System	1H-Benzimidazole-2-acetonitrile (4414-88-4)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302+H312+H332-H315-H319-H335

Precautionary statements

P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

20/21/22-36/37/38

Safety Statements

26-37/39-24/25

RIDADR

3276

WGK Germany

RTECS

DD5650000

TSCA

TSCA listed

HazardClass

6.1

PackingGroup

III

HS Code

29332900

Storage Class

13 - Non Combustible Solids

Hazard Classifications

Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

Toxicity

LD50 ivn-mus: 56 mg/kg CSLNX* NX#04148

NFPA 704

	1
0		0

2-(Cyanomethyl)benzimidazole price More Price(36)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	B5291	(2-Benzimidazolyl)acetonitrile 97%	4414-88-4	10g	$97.2	2025-07-31	Buy
TCI Chemical	B2821	(2-Benzimidazolyl)acetonitrile >96.0%(GC)(T)	4414-88-4	5g	$44	2025-07-31	Buy
TCI Chemical	B2821	(2-Benzimidazolyl)acetonitrile >96.0%(GC)(T)	4414-88-4	25g	$151	2025-07-31	Buy
TRC	C990120	2-(Cyanomethyl)benzimidazole	4414-88-4	100mg	$45	2021-12-16	Buy
TRC	C990120	2-(Cyanomethyl)benzimidazole	4414-88-4	500mg	$65	2021-12-16	Buy

Product number	Packaging	Price	Buy
B5291	10g	$97.2	Buy
B2821	5g	$44	Buy
B2821	25g	$151	Buy
C990120	100mg	$45	Buy
C990120	500mg	$65	Buy

2-(Cyanomethyl)benzimidazole Chemical Properties,Uses,Production

Chemical Properties

LIGHT BEIGE FINE CRYSTALLINE POWDER

Uses

2-Benzimidazoleacetonitrile, is used as a pharmaceutical intermediate. It is also used as an intermediate in organic synthesis.

Safety Profile

Poison by intravenous route. Seealso NITRILES. When heated to decomposition it emitstoxic fumes of NOx.

Synthesis

105-56-6

95-54-5

4414-88-4

To the dry solid of o-phenylenediamine (1.08 g, 10 mmol) was added ethyl cyanoacetate (1.13 g, 10 mmol). The reaction mixture was placed in an oil bath and heated at 120 °C for 30 min, followed by cooling to room temperature. Upon completion of the reaction, the product was collected by filtration and ground with diethyl ether for purification. Finally, recrystallization was carried out from ethanol to give 2-cyanomethylbenzimidazole.

References

[1] Chemical and Pharmaceutical Bulletin, 2018, vol. 66, # 3, p. 309 - 318
[2] ChemMedChem, 2016, vol. 11, # 5, p. 539 - 548
[3] European Journal of Medicinal Chemistry, 2017, vol. 126, p. 853 - 869
[4] European Journal of Medicinal Chemistry, 2017, vol. 136, p. 270 - 282
[5] Chinese Chemical Letters, 2010, vol. 21, # 5, p. 519 - 523

2-(Cyanomethyl)benzimidazole Preparation Products And Raw materials

Raw materials

Ethyl cyanoacetate o-Phenylenediamine 2-(4-Diethylamino-2-hydroxybenzoyl)benzoic acid

Preparation Products

COUMARIN 7 Solvent Red 196 Coumarin 30 Solvent Red 197 1H-Benzimidazole-2-aceticacid,methylester(9CI)

COUMARIN 7 DISPERSE RED 277 3-(1H-benzoimidazol-2-yl)-N,N-diethyl-2-imino-chromen-7-amine 11-oxo-5,7,8,9,10,11-hexahydrobenzo[4,5]imidazo[1,2-b]isoquinoline-6-carbonitrile 1H-Benzimidazole-2-acetonitrile,alpha-(1-methylethylidene)-(9CI)

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2-(Cyanomethyl)benzimidazole Suppliers

Global( 263)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	+86-13017695106 +86-13676922317	jiuyitime@fdachem.com	China	16513	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29833	58
Xiamen Shindano Biotechnology Co.,ltd	0592-6266840 15750707980	sales@chemsdano.com	China	291	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Shenzhen Excellent Biotech Co., Ltd.	13480692018	ramyan@ex-biotech.com	CHINA	954	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9636	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Alfa Chemistry		info@alfa-chemistry.com	United States	2344	58

Supplier	Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	58
Capot Chemical Co.,Ltd.	60
career henan chemical co	58
Xiamen Shindano Biotechnology Co.,ltd	58
Alchem Pharmtech,Inc.	58
Shenzhen Excellent Biotech Co., Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
Antai Fine Chemical Technology Co.,Limited	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Alfa Chemistry	58

View Lastest Price from 2-(Cyanomethyl)benzimidazole manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-10-13	(2-Benzimidazolyl)acetonitrile 4414-88-4	US $1.60-6.60 / kg	1kg	99%	100kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2021-08-12	2-(Cyanomethyl)benzimidazole 4414-88-4	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2021-07-02	2-(Cyanomethyl)benzimidazole 4414-88-4	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

(2-Benzimidazolyl)acetonitrile
4414-88-4
US $1.60-6.60 / kg
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

2-(Cyanomethyl)benzimidazole
4414-88-4
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

2-(Cyanomethyl)benzimidazole
4414-88-4
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

2-(Cyanomethyl)benzimidazole Spectrum

2-(Cyanomethyl)benzimidazole(4414-88-4)¹HNMR 2-(Cyanomethyl)benzimidazole(4414-88-4)IR 2-(Cyanomethyl)benzimidazole(4414-88-4)FT-IR

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2-Benzimidazoleacetonitrile,99% 2-Kyanmethylbenzimidazol [Czech] 2-Kyanmethylbenzimidazol [Czech] 2-(1H-benzimidazol-2-yl)ethanenitrile 1h-benzimidazole-2-acetonitrile 2-nitrile methylbenzimidazole 5-(CYANOMETHYL)BENZIMIDAZOLE,99% 1H-Benzimidazole-2-acetonitrile(9CI) 1H-benzimidazol-2-ylacetonitrile (1H-Benzimidazole-2-yl)acetonitrile 2-(Cyanomethyl)-1H-benzoimidazole 2-(Cyanomethyl)benzimidazole,99% BenziMidazole-2-acetonitrile 2-(Cyanomethyl)-1H-benzimidazole (Benzimidazol-2-yl)acetonitrile 2-(1H-1,3-benzodiazol-2-yl)acetonitrile 2-BENZIMIDAZOLYACETONITRILE (2-BenziMidazolyl)acetonitrile, 96.0%(GC&T 2-benzimidazolyl-acetonitril 2-cyanomethyl-benzimidazol 2-kyanmethylbenzimidazol AURORA KA-5429 IFLAB-BB F0266-2601 LABOTEST-BB LT00159463 2-BENZIMIDAZOLE-ACETONITRILE 2-BENZIMIDAZOLYLACETONITRILE 2-(CYANOMETHYL)BENZIMIDAZOLE (1H-BENZOIMIDAZOL-2-YL)-ACETONITRILE 1H-1,3-BENZIMIDAZOL-2-YLMETHYL CYANIDE Benzimidazolylacetonitrile AKOS BC-1506 (benzimidazol-2-yl)ethanenitrile 2-(1H-benzo[d]imidazol-2-yl)acetonitrile 2-CYANOMETHYLBENZIMIDAZOLE (2-BENZIMIDAZOLYLACETONITRILE) CYANOMETHYLBENZIMIDAZOLE (2-Benzimidazolyl)acetonitrile > 96.0%(GC& 4414-88-4 C9H7N3 Building Blocks Benzimidazoles Heterocyclic Building Blocks Oxidation Synthetic Reagents Imidazol&Benzimidazole Electronic Chemicals Benzimidazoles Building Blocks Chemical Synthesis Heterocyclic Building Blocks BENZIMIDAZOLE Intermediates of Dyes and Pigments