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ChemicalBook >> CAS DataBase List >>2,3-DIFLUORO-6-METHOXYBENZALDEHYDE

2,3-DIFLUORO-6-METHOXYBENZALDEHYDE

2,3-DIFLUORO-6-METHOXYBENZALDEHYDE Structure
2,3-DIFLUORO-6-METHOXYBENZALDEHYDE structure
CAS No.
187543-87-9
Chemical Name:
2,3-DIFLUORO-6-METHOXYBENZALDEHYDE
Synonyms
Zavegepant Impurity 56;5,6-Difluoro-o-anisaldehyde;5,6-Difluoro-o-anisaldehyde>2,3-Difluoro-6-methoxybezaldehyde;2,3-DIFLUORO-6-METHOXYBENZALDEHYDE;Benzaldehyde, 2,3-difluoro-6-methoxy-;2,3-Difluoro-6-methoxybenzaldehyde98%;2,3-Difluoro-6-methoxybenzaldehyde 98%;2,3-DIFLUORO-6-METHOXY-BENZALDEHYD, 98+%;3,4-Difluoro-2-formylanisole, 5,6-Difluoro-o-anisaldehyde
CBNumber:
CB0357506
Molecular Formula:
C8H6F2O2
Molecular Weight:
172.13
MDL Number:
MFCD02093968
MOL File:
187543-87-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 22:59:47
Product description Number Pack Size Price
5,6-Difluoro-o-anisaldehyde >97.0%(GC) D3885 1g $113
5,6-Difluoro-o-anisaldehyde >97.0%(GC) D3885 5g $420
2,3-Difluoro-6-methoxybenzaldehyde 98% PC4118 1g $25
2,3-Difluoro-6-methoxybenzaldehyde 98% PC4118 5g $88
2,3-Difluoro-6-methoxybenzaldehyde 98% PC4118 25g $262
More product size
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2,3-DIFLUORO-6-METHOXYBENZALDEHYDE Properties

Melting point 55-57
Boiling point 233.0±35.0 °C(Predicted)
Density 1.289±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
form powder to crystal
color White to Light yellow to Light orange
Sensitive Air Sensitive
InChI InChI=1S/C8H6F2O2/c1-12-7-3-2-6(9)8(10)5(7)4-11/h2-4H,1H3
InChIKey AKOJAYHBKACKNJ-UHFFFAOYSA-N
SMILES C(=O)C1=C(OC)C=CC(F)=C1F
CAS DataBase Reference 187543-87-9(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-37
Hazard Note  Irritant/Air Sensitive
HS Code  29130000
NFPA 704
1
2 0

2,3-DIFLUORO-6-METHOXYBENZALDEHYDE price More Price(58)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical D3885 5,6-Difluoro-o-anisaldehyde >97.0%(GC) 187543-87-9 1g $113 2026-04-30 Buy
TCI Chemical D3885 5,6-Difluoro-o-anisaldehyde >97.0%(GC) 187543-87-9 5g $420 2026-04-30 Buy
Apolloscientific PC4118 2,3-Difluoro-6-methoxybenzaldehyde 98% 187543-87-9 1g $25 2026-06-04 Buy
Apolloscientific PC4118 2,3-Difluoro-6-methoxybenzaldehyde 98% 187543-87-9 5g $88 2026-06-04 Buy
Apolloscientific PC4118 2,3-Difluoro-6-methoxybenzaldehyde 98% 187543-87-9 25g $262 2026-06-04 Buy
Product number Packaging Price Buy
D3885 1g $113 Buy
D3885 5g $420 Buy
PC4118 1g $25 Buy
PC4118 5g $88 Buy
PC4118 25g $262 Buy

2,3-DIFLUORO-6-METHOXYBENZALDEHYDE Chemical Properties,Uses,Production

Synthesis

N,N-Dimethylformamide

68-12-2

3,4-Difluoroanisole

115144-40-6

2,3-DIFLUORO-6-METHOXYBENZALDEHYDE

187543-87-9

a) General procedure for the synthesis of 2,3-difluoro-6-methoxybenzaldehyde: A 2 M solution of diisopropylaminolithium THF/n-heptane (171 mL, 341 mmol) was diluted with dry THF (250 mL) under nitrogen protection and cooled to -75°C. A solution of 3,4-difluoroanisole (46.8 g, 325 mmol) in anhydrous THF (100 mL) was added slowly dropwise and stirred for 1 hour keeping the temperature at -75 °C. Subsequently, dry N,N-dimethylformamide (27.6 mL, 358 mmol) was added slowly and stirring was continued at -70 °C for 10 min. After the reaction was completed, acetic acid (30 mL) and water (400 mL) were added and warmed to 10 °C. The reaction mixture was extracted with ether (2 x 300 mL). The organic phases were combined and washed sequentially with water (250 mL), 0.2N aqueous hydrochloric acid (400 mL) and brine (2 x 250 mL), dried with anhydrous magnesium sulfate, and the solvent was concentrated under reduced pressure to give a red to orange oil, which was allowed to stand and crystallized. Purification by recrystallization from ether/petroleum ether (40-60 °C) afforded the target product 2,3-difluoro-6-methoxybenzaldehyde (53.0 g, 95% yield).1H NMR (300 MHz, CDCl3) δ: 10.40 (1H, s, CHO), 7.37 (1H, q, ArH), 6.71 (1H, m, ArH), 3.93 ( 3H, s, OCH3).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 21, p. 5395 - 5399
[2] Patent: US2009/118546, 2009, A1. Location in patent: Page/Page column 5-6
[3] Patent: WO2004/43904, 2004, A1. Location in patent: Page 39 - 40
[4] Patent: US2011/124686, 2011, A1. Location in patent: Page/Page column 45
[5] Patent: WO2017/221092, 2017, A1. Location in patent: Paragraph 00142

2,3-DIFLUORO-6-METHOXYBENZALDEHYDE synthesis

758-16-7
115144-40-6
187543-87-9
Synthesis of 2,3-DIFLUORO-6-METHOXYBENZALDEHYDE from N,N-DIMETHYLTHIOFORMAMIDE and 3,4-Difluoroanisole

2,3-DIFLUORO-6-METHOXYBENZALDEHYDE Preparation Products And Raw materials

Raw materials

N,N-Dimethylformamide N,N-DIMETHYLTHIOFORMAMIDE 3,4-Difluoroanisole Heptane Lithium diisopropylamide
Tetrahydrofuran

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Preparation Products

Linzagolix

2,3-DIFLUORO-6-METHOXYBENZALDEHYDE Suppliers

Global( 179)Suppliers
Supplier Tel Email Country ProdList Advantage
SHAANXI LIGHTE OPTOELECTRONICS MATERIAL CO., LTD 		+86-17691239725 +86-15529797525 lijiasheng@ltom.com China 185 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
Fluoropharm Co., Ltd. 		+86-0571-85586753 +86-13336034509 sales@fluoropharm.com China 1445 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29815 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Wuhan Chemwish Technology Co., Ltd 		027-67849912 sales@chemwish.com CHINA 10821 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49979 58
Fuxin Pharmaceutical 		+86-021-021-50872116 +8613122107989 contact@fuxinpharm.com China 10000 58
ENBRIDGE PHARMTECH CO., LTD. 		+8613812269233 tinayang@enbridgepharm.com China 306 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
Supplier Advantage
SHAANXI LIGHTE OPTOELECTRONICS MATERIAL CO., LTD 		58
Capot Chemical Co.,Ltd. 		60
Fluoropharm Co., Ltd. 		60
career henan chemical co 		58
Alchem Pharmtech,Inc. 		58
Wuhan Chemwish Technology Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
Fuxin Pharmaceutical 		58
ENBRIDGE PHARMTECH CO., LTD. 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58

View Lastest Price from 2,3-DIFLUORO-6-METHOXYBENZALDEHYDE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,3-DIFLUORO-6-METHOXYBENZALDEHYDE pictures 2025-12-01 2,3-DIFLUORO-6-METHOXYBENZALDEHYDE
187543-87-9
 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd
2,3-DIFLUORO-6-METHOXYBENZALDEHYDE pictures 2022-11-10 2,3-DIFLUORO-6-METHOXYBENZALDEHYDE
187543-87-9
 1Kg 99%HPLC 20 tons SHAANXI LIGHTE OPTOELECTRONICS MATERIAL CO., LTD
5,6-Difluoro-o-anisaldehyde pictures 2022-04-22 5,6-Difluoro-o-anisaldehyde
187543-87-9
 98%min 100kgs/month Shanghai Rlavie Technology Co ltd

2,3-DIFLUORO-6-METHOXYBENZALDEHYDE Spectrum

2,3-DIFLUORO-6-METHOXYBENZALDEHYDE(187543-87-9)1HNMR2,3-DIFLUORO-6-METHOXYBENZALDEHYDE(187543-87-9)FT-IR

187543-87-9(2,3-DIFLUORO-6-METHOXYBENZALDEHYDE)Related Search:

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5,6-Difluoro-o-anisaldehyde 2,3-Difluoro-6-methoxybezaldehyde 3,4-Difluoro-2-formylanisole, 5,6-Difluoro-o-anisaldehyde 2,3-DIFLUORO-6-METHOXYBENZALDEHYDE 2,3-Difluoro-6-methoxybenzaldehyde 98% 2,3-Difluoro-6-methoxybenzaldehyde98% 2,3-DIFLUORO-6-METHOXY-BENZALDEHYD, 98+% 5,6-Difluoro-o-anisaldehyde> Benzaldehyde, 2,3-difluoro-6-methoxy- Zavegepant Impurity 56 187543-87-9 Fluorine series Benzaldehyde Aromatic Aldehydes & Derivatives (substituted)