ChemicalBook >> CAS DataBase List >>3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one structure

CAS No.: 63234-80-0

Chemical Name:: 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

Synonyms: 3-(2-Chloroethyl)-6;Risperidone Impurity L;Paliperidone Impurity 26;Risperidone EP IMpurity L;Risperidone Chloro IMpurity;Risperidone Intermediate III;3-(2-Chloro-ethyl)-2-methyl-6,7,8,9-tetrahydro-;Risperidone Impurity 12(Risperidone EP Impurity L);-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one;Risperidone EP Impurity L (Risperidone Chloroethyl Impurity)

CBNumber:: CB0359227

Molecular Formula:: C11H15ClN2O

Molecular Weight:: 226.7

MDL Number:: MFCD06200813

MOL File:: 63234-80-0.mol

MSDS File:: SDS

Last updated:2025-09-25 17:15:13

Product description	Number	Pack Size	Price
3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one >98.0%(GC)(T)	C2433	5g	$112
3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one >98.0%(GC)(T)	C2433	25g	$337
3-(2-Chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one	C366155	5g	$245
3-(2-Chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one	FC20229	250g	$625
3-(2-CHLOROETHYL)-6,7,8,9-TETRAHYDRO-2-METHYL-4H-PYRIDO [1,2-A] PYRIMIDINE-4-ONE 95.00%	HCH0020290	1G	$739.2
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3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one Properties

Melting point	68.5-69.5 °C
Boiling point	337 °C
Density	1.30
Flash point	157 °C
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	3.58±0.70(Predicted)
form	Solid
color	White to Off-White
InChI	InChI=1S/C11H15ClN2O/c1-8-9(5-6-12)11(15)14-7-3-2-4-10(14)13-8/h2-7H2,1H3
InChIKey	CMWCQQUYLPYOMY-UHFFFAOYSA-N
SMILES	C12CCCCN1C(=O)C(CCCl)=C(C)N=2
CAS DataBase Reference	63234-80-0(CAS DataBase Reference)
FDA UNII	2089CR1AQN

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

Hazard Codes

Risk Statements

Safety Statements

RIDADR

UN3261

HS Code

2933.99.9701

HazardClass

IRRITANT

Limited Quantities

1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)

NFPA 704

	0
2		0

3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one price More Price(31)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	C2433	3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one >98.0%(GC)(T)	63234-80-0	5g	$112	2025-07-31	Buy
TCI Chemical	C2433	3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one >98.0%(GC)(T)	63234-80-0	25g	$337	2025-07-31	Buy
TRC	C366155	3-(2-Chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one	63234-80-0	5g	$245	2021-12-16	Buy
Biosynth Carbosynth	FC20229	3-(2-Chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one	63234-80-0	250g	$625	2021-12-16	Buy
American Custom Chemicals Corporation	HCH0020290	3-(2-CHLOROETHYL)-6,7,8,9-TETRAHYDRO-2-METHYL-4H-PYRIDO [1,2-A] PYRIMIDINE-4-ONE 95.00%	63234-80-0	1G	$739.2	2021-12-16	Buy

Product number	Packaging	Price	Buy
C2433	5g	$112	Buy
C2433	25g	$337	Buy
C366155	5g	$245	Buy
FC20229	250g	$625	Buy
HCH0020290	1G	$739.2	Buy

3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

3-(2-Chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one (Risperidone EP Impurity L) is an intermediate in the synthesis of Risperidone (R525000), which is a combined serotonin (5-HT2) and dopamine (D2) receptor antagonist.

Synthesis

3-(2-Chloroethyl)-2-methylpyrido[1,2-a]pyrimidin-4-one

41078-70-0

3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

63234-80-0

The general procedure for the synthesis of 3-(2-chloroethyl)-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one from 3-(2-chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one is as follows: 28 g of 3-(2-chloroethyl)-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one obtained in step A) was dissolved in 90 mL 6N hydrochloric acid. -a]pyrimidin-4-one was dissolved in 90 mL of 6N hydrochloric acid, followed by the addition of 2.8 g of 10% palladium carbon catalyst to the solution. The reaction mixture was subjected to 35 psi hydrogen pressure and hydrogenated at room temperature with stirring for 8 hours. Upon completion of the reaction, the mixture was filtered through diatomaceous earth (Cellite) to remove the catalyst. The filtrate was concentrated under reduced pressure to give a residue. To the residue was added 200 mL of isopropanol and the mixture was stirred. The precipitated solid was collected by filtration and dried to give 25.1 g of the target product 3-(2-chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one as white crystals in 90% yield.

References

[1] Patent: WO2004/35573, 2004, A1. Location in patent: Page 9
[2] Journal of the American Chemical Society, 2017, vol. 139, # 24, p. 8267 - 8276
[3] Letters in Drug Design and Discovery, 2011, vol. 8, # 10, p. 988 - 995
[4] Medicinal Chemistry, 2013, vol. 9, # 2, p. 240 - 248

3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one synthesis

Synthesis of 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one from 3-(2-Chloroethyl)-2-methylpyrido[1,2-a]pyrimidin-4-one

3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one Preparation Products And Raw materials

Raw materials

Ammonium hydroxide Palladium hydroxide Toluene Phosphorus oxitrichloride Ethyl acetate

Hydrochloric acid Hydrogen Dichloromethane 2-Acetylbutyrolactone 2-Aminopyridine

Isopropyl alcohol PETROLEUM ETHER 3-(2-Chloroethyl)-2-methylpyrido[1,2-a]pyrimidin-4-one

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Preparation Products

3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one Suppliers

Global( 330)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Haibo Biotechnology Co., Ltd	+undefined18602966907	qinhe02@xaltbio.com	China	997	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21597	55
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418679 +8618949832763	info@tnjchem.com	China	2988	55
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3619	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29831	58
Jinan Shengqi pharmaceutical Co,Ltd	86+18663751872	christine@shengqipharm.com	CHINA	491	58
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2950	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	sales@amoychem.com	China	6369	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58

Supplier	Advantage
Shaanxi Haibo Biotechnology Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Hefei TNJ Chemical Industry Co.,Ltd.	55
Shanghai Zheyan Biotech Co., Ltd.	58
career henan chemical co	58
Jinan Shengqi pharmaceutical Co,Ltd	58
Jinan Finer Chemical Co., Ltd	58
Xiamen AmoyChem Co., Ltd	58
Hubei xin bonus chemical co. LTD	58

View Lastest Price from 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-07-11	3-2-(chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pirido[1,2-a]pirimidin-4-one 63234-80-0	US $300.00-155.00 / kg	1kg	98%	500kgs/month	Sach biotech Co.,Ltd
2024-04-12	3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one 63234-80-0	US $0.00 / kg	1kg	99%	2000ton	Shaanxi Haibo Biotechnology Co., Ltd
2019-07-06	3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4h-pyrido-(1,2-a) pyrimidin-4-one 63234-80-0	US $1.00 / KG	1KG	98%	100KG	Career Henan Chemical Co

3-2-(chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pirido[1,2-a]pirimidin-4-one
63234-80-0
US $300.00-155.00 / kg
98%
Sach biotech Co.,Ltd

3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
63234-80-0
US $0.00 / kg
99%
Shaanxi Haibo Biotechnology Co., Ltd

3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4h-pyrido-(1,2-a) pyrimidin-4-one
63234-80-0
US $1.00 / KG
98%
Career Henan Chemical Co

63234-80-0(3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one)Related Search:

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Pirimiphos-methyl Methylparaben Thiophanate-methyl Methyl 2,4-Difluorobenzoyl Risperidone IMpurity

Desfluoro Risperidone Risperidone Pyrimidinone-N-oxide 6-Fluoro-3-[1-bis-[2-(methyl-6,7,8,9-tetrahydropyridol[1,2,a]pyrimidin-4-one-3-yl)ethyl]piperidinium]benzisoxazole Iodide

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3-(2-Chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]-pyrididine-4-one (intermediate of Risperidone) 3-(2-CHLOROETHYL)-2-METHYL-6,7,8,9-TETRAHYDRO-4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE 3-(2-CHLORO-ETHYL)-2-METHYL-6,7,8,9-TETRAHYDRO-PYRIDO[1,2-A]PYRIMIDIN-4-ONE 3-(2-CHLOROETHYL)-6,7,8,9-TETRAHYDRO-2-METHYL-4H-PYRIDINO[1,2-A]PYRIMIDINE-4-ONE 3-(2-CHLOROETHYL)-6,7,8,9-TETRAHYDRO-2-METHYL-4H-PYRIDO(1,2A)PYRIMIDINE-4-ONE 3-(2-CHLOROETHYL)-6,7,8,9-TETRAHYDRO-2-METHYL-4H-PYRLDO[1,2-A]PYRIMDIN-4-ONE 3-2(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-alpha]pyrimnidin-4-one 3-2(2-CHLOROETHYL)-6,7,8,9-TETRAHYDRO-2-METHYL-4H-PYRIDO[1,2-A]PYRIMDIN-4-ONE 8-(CHLOROETHYL)-9-METHYL-6,10-DIAZABICYCLO[4.4.0]DECA-8,10-DIEN-7-ONE 3-(2-CHLOROETHYL)-2-METHYL-6,7,8,9-TETRAHYDRO-4H-PYRIDO[1,2-ALPHA]PYRIMIDIN-4-ONE 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2
-a]pyrimidin-4-one 3-(2-Chloroethyl)-2-Methyl-6,7,8,9-tetrahydro-4H-pyrimidine-4-one 3-(2-CHLOROETHYL)-2-METHYL-6,7,8,9-TETRAHYDRO-4H-PYRIDO[1, 2-A]-PYRIMIDIN-4-ONE ( RISPERIDONE INTERMEDIATE ). 3-(2-CHLOROETHYL)-6,7,8,9-TETRAHYDRO-2-METHYL-4H-PYRIDO[1,2-A]-PYRIMIDIN-4-ONE(RISPERIDONEINTERMEDIATE) 3-(2-CHLOROETHYL)-2-METHYL-6,7,8,9-TETRAHYDRO-4H-PYRIDO[1,2-A]-PYRIDIDINE-4-ONE 3-(2-chloroethyl)-2-methyl-4H,6H,7H,8H,9H-pyrido[1,2-a]pyrimidin-4-one Risperidone Intermediate III 3-(2-Chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-α]pyrimidin-4-one 3-(2-Chloro-ethyl)-2-methyl-6,7,8,9-tetrahydro- 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one 4H-Pyrido[1,2-a]pyrimidin-4-one, 3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl- 3-(2-Chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]-pyrimidin-4-one ,98% 3-(2-Chloroethyl)-6 3-(2-chloroethyl)-2-Methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]py Phenyl(4-piperidyl)Methanone3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-Methyl-4H-pyrido[1,2-a]pyriMidin-4-one Risperidone Chloro IMpurity Risperidone EP IMpurity L 3-(2-chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4Hpyrido[1,2-a]pyrimidin-4-one (piperidopyrimidinone intermediate) Paliperidone Impurity 26 Risperidone Impurity 12(Risperidone EP Impurity L) 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one > -6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one Risperidone Impurity L 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one ISO 9001：2015 REACH Risperidone EP Impurity L (Risperidone Chloroethyl Impurity) 3-(2-Chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-... TIANFU-CHEM - 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one, ≥ 98.0% 3-2-(chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pirido[1,2-a]pirimidin-4-one 3-(2-Chloro)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one 3-(2-Chloroethyl)-6,7,8,9-TH-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one 3-(2-Chloroethyl)-2-Methyl-6,7,8,9-Tetrohydro-4H-Pyridol[1,2-a]-Pyrimidin-4-One 63234-80-0 63274-80-0 62234-80-0 63274-80-0 C11H15ClN2O Bases & Related Reagents Intermediates & Fine Chemicals Nucleotides Pharmaceuticals Intermediates Nucleotides and Nucleosides (intermediate of Risperidone)