(S)-ropivacaine hydrochloride hydrate
- CAS No.
- 132112-35-7
- Chemical Name:
- (S)-ropivacaine hydrochloride hydrate
- Synonyms
- ROPIVACAINE HCL;ROPIVACAINE HYDROCHLORIDE MONOHYDRATE;Ropivacaine hydrochloride hydrate;LEA-103;LEA-103 HCl;Ropivacaine HCI;S-ROPIVACAINE HCL;Ropivacaine HCl.H2O;Ropivacaine HCl (mono);Ropivacaine HCl hydrate
- CBNumber:
- CB0369811
- Molecular Formula:
- C17H26N2O.ClH.H2O
- Molecular Weight:
- 328.88
- MDL Number:
- MFCD02102164
- MOL File:
- 132112-35-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Ropivacaine hydrochloride monohydrate ≥98% (HPLC) | R0283 | 10mg | $86.5 |
| Ropivacaine hydrochloride monohydrate European Pharmacopoeia (EP) Reference Standard | Y0000742 | 10 mg | $118 |
| Ropivacaine hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material | PHR2303 | 500 mg | $273 |
| Ropivacaine hydrochloride United States Pharmacopeia (USP) Reference Standard | 1605500 | 200mg | $467 |
| Ropivacaine hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material | PHR2303 | 500MG | $253 |
| More product size | |||
| Melting point | 267-269°C |
|---|---|
| alpha | D20 -7.28° (c = 2 in water) |
| storage temp. | 2-8°C |
| solubility | H2O: soluble5mg/mL, clear |
| form | powder |
| color | white to off-white |
| optical activity | [α]/D -9 to -12, c = 1 in methanol |
| Water Solubility | H2O: 5mg/mL, clear |
| InChI | InChI=1/C17H26N2O.ClH.H2O/c1-4-11-19-12-6-5-10-15(19)17(20)18-16-13(2)8-7-9-14(16)3;;/h7-9,15H,4-6,10-12H2,1-3H3,(H,18,20);1H;1H2/t15-;;/s3 |
| InChIKey | VSHFRHVKMYGBJL-CKUXDGONSA-N |
| SMILES | [C@H]1(CCCCN1CCC)C(=O)NC1=C(C)C=CC=C1C.O.Cl |&1:0,r| |
| CAS DataBase Reference | 132112-35-7(CAS DataBase Reference) |
| NCI Dictionary of Cancer Terms | ropivacaine hydrochloride |
| FDA UNII | V910P86109 |
| NCI Drug Dictionary | ropivacaine hydrochloride |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|---|---|
| Signal word | Danger |
| Hazard statements | H318 |
| Precautionary statements | P280-P305+P351+P338 |
| Hazard Codes | T,Xi |
| Risk Statements | 26/27/28-41 |
| Safety Statements | 22-36/37/39-45-39-26 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
| HS Code | 2933399090 |
(S)-ropivacaine hydrochloride hydrate price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | R0283 | Ropivacaine hydrochloride monohydrate ≥98% (HPLC) | 132112-35-7 | 10mg | $86.5 | 2025-07-31 | Buy |
| Sigma-Aldrich | Y0000742 | Ropivacaine hydrochloride monohydrate European Pharmacopoeia (EP) Reference Standard | 132112-35-7 | 10 mg | $118 | 2025-07-31 | Buy |
| Sigma-Aldrich | PHR2303 | Ropivacaine hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material | 500 mg | $273 | 2025-07-31 | Buy | |
| Sigma-Aldrich | 1605500 | Ropivacaine hydrochloride United States Pharmacopeia (USP) Reference Standard | 132112-35-7 | 200mg | $467 | 2025-07-31 | Buy |
| Sigma-Aldrich | PHR2303 | Ropivacaine hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material | 132112-35-7 | 500MG | $253 | 2024-03-01 | Buy |
(S)-ropivacaine hydrochloride hydrate Chemical Properties,Uses,Production
Description
(–)-Ropivacaine is a potent and reversible blocker of sodium channels in nerve fibers. In vivo, (–)-ropivacaine induces complete impairment of proprioception, motor function, and nociception in the hindleg of rats when 100 μL of an 8 mM solution is injected percutaneously into the sciatic nerve. (–)-Ropivacaine depresses myocardial contractile force in isolated rat hearts less potently than (±)-ropivacaine, as well as (–)- and (±)-bupivacaine . Formulations containing (–)-ropivacaine have been used as local anesthetics during surgery and childbirth.
Chemical Properties
White Solid
Uses
Anesthetic (local).
Uses
Ropivacaine hydrochloride monohydrate has been used as an analyte in tandem mass spectrometry and as an amide-based local anaesthetic to test its effect on breast cancer cell methylation.
Definition
ChEBI: The monohydrate form of (S)-ropivacaine hydrochloride.
General Description
Ropivacaine has lidocaine-related structure with tertiary amine side chains.?It is a pure S(-)enantiomer with a propyl group on the piperidine nitrogen atom.
Biochem/physiol Actions
Local anaesthetic with less cardiotoxicity than bupivacaine; causes reversible blockade of impulse propagation along nerve fibres by preventing the inward movement of sodium ions through the cell membrane of the nerve fibers.
Synthesis
84057-95-4
132112-35-7
The general procedure for the synthesis of (S)-N-(2,6-dimethylphenyl)-1-propyl-2-piperidine carboxamide hydrochloride hydrate using (S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide as raw material was as follows: about 3 g of (S)-N-(2,6-dimethylphenyl)-1 -propyl-2-piperidine carboxamide was dissolved in 10 mL of deionized water and to this solution, 50 mL of acetone preheated to 60°C was slowly added. Under stirring conditions, concentrated hydrochloric acid was added dropwise to adjust the pH to 2.0. Subsequently, the reaction mixture was heated to reflux until a clarified solution was formed. 20 mL of acetone was added to the reaction system and the precipitated solid product was filtered after cooling to room temperature. The solid was washed three times with cold acetone and dried in a vacuum drying oven at 40°C for 12 h. 2.9 g of white crystalline (S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride hydrate was obtained in 82% yield. The water content of the product was 5.6% as determined by Karl Fischer's method.
References
[1] Patent: US2006/276654, 2006, A1. Location in patent: Page/Page column 5
[2] Patent: US2006/276654, 2006, A1. Location in patent: Page/Page column 5
(S)-ropivacaine hydrochloride hydrate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanxi Naipu Import and Export Co.,Ltd | +86-13734021967 +8613734021967 | kaia@neputrading.com | China | 1001 | 58 |
| Sichuan Zhuoyu Yantang Technology Co., Ltd. | +8613288715578 | sales@sichuanzyyt.com | China | 12247 | 58 |
| Firsky International Trade (Wuhan) Co., Ltd | +8615387054039 | admin@firsky-cn.com | China | 427 | 58 |
| shandong perfect biotechnology co.ltd | +86-53169958659 +86-13153181156 | sales@sdperfect.com | China | 294 | 58 |
| Hebei Xinsheng New Material Technology Co., LTD. | +86-16632316109 | xinshengkeji@xsmaterial.com | China | 1085 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 973 | 58 |
| Wuhan Ruichi Technology Co., Ltd | +8613545065237 | admin@whrchem.com | China | 153 | 58 |
| Shaanxi Franta Biotechnology Co., Ltd | +86-13082019107 | admin@flanderff.com | China | 244 | 58 |
| Apeloa production Co.,Limited | +8619933239880 | admin@apcl.com.cn | China | 861 | 58 |
| Shaanxi Xianhe Biotech Co., Ltd | +86-17709210191; +8617709210191 | Jerry@xhobio.com | China | 883 | 58 |
View Lastest Price from (S)-ropivacaine hydrochloride hydrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-10-22 | Ropivacaine hydrochloride
132112-35-7
|
US $0.00-0.00 / kg | 1kg | 0.99 | 800kg | Wuhan Biocar Pharmacy CO.,Ltd. | |
 |
2025-10-22 | Ropivacaine hydrochloride
132112-35-7
|
US $0.00 / KG | 1KG | 0.99 | 1000KG | Shaanxi Xianhe Biotech Co., Ltd | |
 |
2025-10-20 | Ropivacaine hydrochloride monohydrate
132112-35-7
|
US $48.00-98.00 / mg | 99.95% | 10g | TargetMol Chemicals Inc. |
-
- Ropivacaine hydrochloride
132112-35-7
- US $0.00-0.00 / kg
- 0.99
- Wuhan Biocar Pharmacy CO.,Ltd.
-
- Ropivacaine hydrochloride
132112-35-7
- US $0.00 / KG
- 0.99
- Shaanxi Xianhe Biotech Co., Ltd
-
- Ropivacaine hydrochloride monohydrate
132112-35-7
- US $48.00-98.00 / mg
- 99.95%
- TargetMol Chemicals Inc.
