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(S)-ropivacaine hydrochloride hydrate

CAS No.
132112-35-7
Chemical Name:
(S)-ropivacaine hydrochloride hydrate
Synonyms
ROPIVACAINE HCL;ROPIVACAINE HYDROCHLORIDE MONOHYDRATE;Ropivacaine hydrochloride hydrate;LEA-103;LEA-103 HCl;Ropivacaine HCI;S-ROPIVACAINE HCL;Ropivacaine HCl.H2O;Ropivacaine HCl (mono);Ropivacaine HCl hydrate
CBNumber:
CB0369811
Molecular Formula:
C17H26N2O.ClH.H2O
Molecular Weight:
328.88
MDL Number:
MFCD02102164
MOL File:
132112-35-7.mol
MSDS File:
SDS
Last updated:2025-10-21 14:56:34
Product description Number Pack Size Price
Ropivacaine hydrochloride monohydrate ≥98% (HPLC) R0283 10mg $86.5
Ropivacaine hydrochloride monohydrate European Pharmacopoeia (EP) Reference Standard Y0000742 10 mg $118
Ropivacaine hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material PHR2303 500 mg $273
Ropivacaine hydrochloride United States Pharmacopeia (USP) Reference Standard 1605500 200mg $467
Ropivacaine hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material PHR2303 500MG $253
More product size

(S)-ropivacaine hydrochloride hydrate Properties

Melting point 267-269°C
alpha D20 -7.28° (c = 2 in water)
storage temp. 2-8°C
solubility H2O: soluble5mg/mL, clear
form powder
color white to off-white
optical activity [α]/D -9 to -12, c = 1 in methanol
Water Solubility H2O: 5mg/mL, clear
InChI InChI=1/C17H26N2O.ClH.H2O/c1-4-11-19-12-6-5-10-15(19)17(20)18-16-13(2)8-7-9-14(16)3;;/h7-9,15H,4-6,10-12H2,1-3H3,(H,18,20);1H;1H2/t15-;;/s3
InChIKey VSHFRHVKMYGBJL-CKUXDGONSA-N
SMILES [C@H]1(CCCCN1CCC)C(=O)NC1=C(C)C=CC=C1C.O.Cl |&1:0,r|
CAS DataBase Reference 132112-35-7(CAS DataBase Reference)
NCI Dictionary of Cancer Terms ropivacaine hydrochloride
FDA UNII V910P86109
NCI Drug Dictionary ropivacaine hydrochloride
UNSPSC Code 41116107
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS05
Signal word  Danger
Hazard statements  H318
Precautionary statements  P280-P305+P351+P338
Hazard Codes  T,Xi
Risk Statements  26/27/28-41
Safety Statements  22-36/37/39-45-39-26
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
HS Code  2933399090

(S)-ropivacaine hydrochloride hydrate price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich R0283 Ropivacaine hydrochloride monohydrate ≥98% (HPLC) 132112-35-7 10mg $86.5 2025-07-31 Buy
Sigma-Aldrich Y0000742 Ropivacaine hydrochloride monohydrate European Pharmacopoeia (EP) Reference Standard 132112-35-7 10 mg $118 2025-07-31 Buy
Sigma-Aldrich PHR2303 Ropivacaine hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material 500 mg $273 2025-07-31 Buy
Sigma-Aldrich 1605500 Ropivacaine hydrochloride United States Pharmacopeia (USP) Reference Standard 132112-35-7 200mg $467 2025-07-31 Buy
Sigma-Aldrich PHR2303 Ropivacaine hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material 132112-35-7 500MG $253 2024-03-01 Buy
Product number Packaging Price Buy
R0283 10mg $86.5 Buy
Y0000742 10 mg $118 Buy
PHR2303 500 mg $273 Buy
1605500 200mg $467 Buy
PHR2303 500MG $253 Buy

(S)-ropivacaine hydrochloride hydrate Chemical Properties,Uses,Production

Description

(–)-Ropivacaine is a potent and reversible blocker of sodium channels in nerve fibers. In vivo, (–)-ropivacaine induces complete impairment of proprioception, motor function, and nociception in the hindleg of rats when 100 μL of an 8 mM solution is injected percutaneously into the sciatic nerve. (–)-Ropivacaine depresses myocardial contractile force in isolated rat hearts less potently than (±)-ropivacaine, as well as (–)- and (±)-bupivacaine . Formulations containing (–)-ropivacaine have been used as local anesthetics during surgery and childbirth.

Chemical Properties

White Solid

Uses

Anesthetic (local).

Uses

Ropivacaine hydrochloride monohydrate has been used as an analyte in tandem mass spectrometry and as an amide-based local anaesthetic to test its effect on breast cancer cell methylation.

Definition

ChEBI: The monohydrate form of (S)-ropivacaine hydrochloride.

General Description

Ropivacaine has lidocaine-related structure with tertiary amine side chains.?It is a pure S(-)enantiomer with a propyl group on the piperidine nitrogen atom.

Biochem/physiol Actions

Local anaesthetic with less cardiotoxicity than bupivacaine; causes reversible blockade of impulse propagation along nerve fibres by preventing the inward movement of sodium ions through the cell membrane of the nerve fibers.

Synthesis

Ropivacaine

84057-95-4

(S)-ropivacaine hydrochloride hydrate

132112-35-7

The general procedure for the synthesis of (S)-N-(2,6-dimethylphenyl)-1-propyl-2-piperidine carboxamide hydrochloride hydrate using (S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide as raw material was as follows: about 3 g of (S)-N-(2,6-dimethylphenyl)-1 -propyl-2-piperidine carboxamide was dissolved in 10 mL of deionized water and to this solution, 50 mL of acetone preheated to 60°C was slowly added. Under stirring conditions, concentrated hydrochloric acid was added dropwise to adjust the pH to 2.0. Subsequently, the reaction mixture was heated to reflux until a clarified solution was formed. 20 mL of acetone was added to the reaction system and the precipitated solid product was filtered after cooling to room temperature. The solid was washed three times with cold acetone and dried in a vacuum drying oven at 40°C for 12 h. 2.9 g of white crystalline (S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride hydrate was obtained in 82% yield. The water content of the product was 5.6% as determined by Karl Fischer's method.

References

[1] Patent: US2006/276654, 2006, A1. Location in patent: Page/Page column 5
[2] Patent: US2006/276654, 2006, A1. Location in patent: Page/Page column 5

84057-95-4
132112-35-7
Synthesis of (S)-ropivacaine hydrochloride hydrate from Ropivacaine

(S)-ropivacaine hydrochloride hydrate Preparation Products And Raw materials

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Shanxi Naipu Import and Export Co.,Ltd
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View Lastest Price from (S)-ropivacaine hydrochloride hydrate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ropivacaine hydrochloride pictures 2025-10-21 Ropivacaine hydrochloride
132112-35-7
US $0.00 / KG 1KG 0.99 1000KG Shaanxi Xianhe Biotech Co., Ltd
Ropivacaine hydrochloride pictures 2025-10-21 Ropivacaine hydrochloride
132112-35-7
US $0.00-0.00 / kg 1kg 0.99 800kg Wuhan Biocar Pharmacy CO.,Ltd.
Ropivacaine hydrochloride monohydrate pictures 2025-10-20 Ropivacaine hydrochloride monohydrate
132112-35-7
US $48.00-98.00 / mg 99.95% 10g TargetMol Chemicals Inc.

(S)-ropivacaine hydrochloride hydrate Spectrum

(S)-1-propyl-2',6'-dimethylanilinoformoxylpiperidine monohydrochloride monohydrate (S)-1-propyl-2',6'-dimethylanilinoformoxylpiperidine,monohydrochloride,monohydrate (S)-Ropivaxaine hydrochloride (S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride (2S)-N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecarboxamide Hydrochloride Hydrate LEA-103 (S)-ropivacaine hydrochloride hydrate Ropivacaine Hydrochloride (200 mg) 1-methy1-1h-tetrazol-5-ylthiol Ropivacaine Hcl monohydrate (S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride monohydrate Ropivacaine Hydrochloride, USP Ropivacaine-(S) Hydrochloride Ropivacaine HCl.H2O Ropivacaine hydrochloride hydrate LEA-103 HCl 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-propyl-, hydrochloride (1:1), (2S)- Ropivacaine hydrochloride (S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride (2S)-N-(2,6-dimethylphenyl)-1-propyl-2-piperidinecarboxamide hydrochloride monohydrate Naropin hydrochloride monohydrate S-ROPIVACAINE HCL (S)-ROPIVACAINE HYDROCHLORIDE ROPIVACAINE HYDROCHLORIDE MONOHYDRATE ROPIVCACAINE HYDROCHLORIDE ROPIVACAINE HCL (S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride hydrate Ropivacaine hydrochloride USP/EP/BP Ropivacaine hydrochloride Naropin Ropivacaine Hydrochloride (1605500) Ropivacaine HCl hydrate Ropivacaine HCI 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-propyl-, hydrochloride, hydrate (1:1:1), (2S)- Ropivacaini Hydrochloridum Monohydricum (2S)-N-(2,6-dimethylphenyl)-1-propyl-2-Piperidinecarboxamide hydrochloride hydrate (1:1:1) Ropivacaine HCl (mono) Ropivacaine HCl H2O IP/USP/BP/EP Ropivacaine hydrochloride monohydrate, 10 mM in DMSO 132112-35-7 13112-35-7 CAS NO.98717-15 132115-35-7 C17H26N2OxHCL C17H26N2OHCl C17H26N2OHCLH2O C17H28N2O2HCl C17H26N2O2HClH2O C17H26N2OClHH2O Inhibitors Chiral Reagents Intermediates & Fine Chemicals Pharmaceuticals API 132112-35-7