1,3,5-Trimethoxybenzene
- CAS No.
- 621-23-8
- Chemical Name:
- 1,3,5-Trimethoxybenzene
- Synonyms
- 1,3,5-Trimethyoxybenzene;Benzene, 1,3,5-trimethoxy-;PHLOROGLUCINOL TRIMETHYL ETHER;2,4,6-Trimethoxybenzene;1,3,5-Methoxybenzene;1,3,5-Trimethoxybenzene Vetec(TM) reagent grade, 98%;Phloroglucinol trimethyl ether, 3,5-Dimethoxyanisole;1,3,5-TriMetho;TRISMETHOXYBENZENE;5-TriMethoxybenzene
- CBNumber:
- CB0371005
- Molecular Formula:
- C9H12O3
- Molecular Weight:
- 168.19
- MDL Number:
- MFCD00008385
- MOL File:
- 621-23-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 1,3,5-Trimethoxybenzene ReagentPlus , ≥99% | 138827 | 10g | $39.6 |
| 1,3,5-Trimethoxybenzene ReagentPlus , ≥99% | 138827 | 50g | $121 |
| 1,3,5-Trimethoxybenzene >98.0%(GC) | P0250 | 25g | $38 |
| 1,3,5-Trimethoxybenzene >98.0%(GC) | P0250 | 100g | $113 |
| 1,3,5-Trimethoxybenzene Standard for quantitative NMR, TraceCERT | 74599 | 1g | $194 |
| More product size | |||
| Melting point | 50-53 °C (lit.) |
|---|---|
| Boiling point | 255 °C (lit.) |
| Density | 1,126g/cm |
| refractive index | 1,533 |
| Flash point | 186 °F |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | methanol: 0.1 g/mL, clear, colorless |
| form | Crystalline Powder |
| color | White to cream |
| Water Solubility | insoluble |
| BRN | 1307993 |
| Cosmetics Ingredients Functions | SKIN CONDITIONING |
| InChI | 1S/C9H12O3/c1-10-7-4-8(11-2)6-9(5-7)12-3/h4-6H,1-3H3 |
| InChIKey | LKUDPHPHKOZXCD-UHFFFAOYSA-N |
| SMILES | COc1cc(OC)cc(OC)c1 |
| LogP | 1.605 (est) |
| CAS DataBase Reference | 621-23-8(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 00VJI3VG3D |
| NIST Chemistry Reference | 1,3,5-Trimethoxybenzene(621-23-8) |
| EPA Substance Registry System | 1,3,5-Trimethoxybenzene (621-23-8) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
| Hazard Codes | Xn,F | |||||||||
| Risk Statements | 22-20/21/22 | |||||||||
| Safety Statements | 24/25-36-26 | |||||||||
| RIDADR | 1325 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DC2810000 | |||||||||
| Hazard Note | Flammable Solid/Harmful | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 4.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29093090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| NFPA 704 |
|
1,3,5-Trimethoxybenzene price More Price(53)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 138827 | 1,3,5-Trimethoxybenzene ReagentPlus , ≥99% | 621-23-8 | 10g | $39.6 | 2026-03-19 | Buy |
| Sigma-Aldrich | 138827 | 1,3,5-Trimethoxybenzene ReagentPlus , ≥99% | 621-23-8 | 50g | $121 | 2026-03-19 | Buy |
| TCI Chemical | P0250 | 1,3,5-Trimethoxybenzene >98.0%(GC) | 621-23-8 | 25g | $38 | 2026-03-19 | Buy |
| TCI Chemical | P0250 | 1,3,5-Trimethoxybenzene >98.0%(GC) | 621-23-8 | 100g | $113 | 2026-03-19 | Buy |
| Sigma-Aldrich | 74599 | 1,3,5-Trimethoxybenzene Standard for quantitative NMR, TraceCERT | 621-23-8 | 1g | $194 | 2026-03-19 | Buy |
1,3,5-Trimethoxybenzene Chemical Properties,Uses,Production
Chemical Properties
white to cream crystalline powder. Insoluble in water.
Uses
1,3,5-Trimethoxybenzene is a major scent component of the Chinese rose odour. 1,3,5-Trimethoxybenzene is also a useful synthetic intermediate and is used to synthesize triaryl- and triheteroarylmethanes.
Definition
ChEBI: 1,3,5-trimethoxybenzene is a methoxybenzene carrying methoxy groups at positions 1, 3 and 5. It has been found to be a biomarker of flavonoid consumption in humans. It has a role as a biomarker and a human xenobiotic metabolite.
Reactions
1,3,5-Trimethoxybenzene is the main component of the Leaf Oil of Eugenia confusa and is also a commonly used chemical reagent in organic synthesis. It can be used in the following reactions:
(1) Friedel–Crafts reaction: In this reaction, 4,5-dichlorocyclopent-4-ene-1,3-dione reacts with 1,3,5-trimethoxybenzene to synthesize 5-(2,4,6-trimethoxyphenyl)-4-chlorocyclopent-4-ene-1,3-dione, and also generates the disubstituted product 3,4-bis-(2,4,6-trimethoxyphenyl)-2-chlorocyclopent-2-ene-1-one[1].
(2) Addition reaction: Using trifluoromethanesulfonic acid as a catalyst, 1,3,5-trimethoxybenzene can react with maleimide to undergo a 1,4-addition reaction to synthesize 3-(2,4,6-trimethoxyphenyl) succinimide. It can also undergo a 1,4-addition reaction with acrylates[2].
(3) Nitration reaction: 1,3,5-Trimethoxybenzene can be nitrated with N2O5 in an organic solvent to prepare 1,3,5-trimethoxy-2,4,6-trinitrobenzene. However, this method is not very practical due to the side reactions of oxidation and coupling[3].
General Description
1,3,5-Trimethoxybenzene effectively cleaves p-methoxybenzyl protecting group on various alcohols and acids. It is the major scent compound present in Chinese rose species.
Synthesis
A solution of anhydrous phloroglucinol (6.3 g，0.05 mole) in dryacetone (100 ml) is refluxed for 6 hr under anhydrous conditions withdimethyl sulphate (15. 6 ml，20.8 g, 0.165 mole) in presence of ignitedpotassium carbonate (40 g).The mixture is filtered, and the inorganic saltswashed with hot acetone (2 × 20 ml). The combined acetone solution isdistilled and the residue macerated with crushed ice. It is extracted withether, the ether extracts washed with sodium hydroxide solution (5%),water，dried (sodium sulphate) and distilled. Yield 1,3,5-Trimethoxybenzene 6 g (71.4 %).M.p 52-3° (lit. m.p.52-53°).
Solubility in organics
Soluble in Methanol, Ether, Ethanol, Benzene.
Solubility in water
Insoluble
Purification Methods
Sublime it under vacuum. [Beilstein 6 III 635, 6 IV 7362.]
References
[1] V. A. EGOROV. Double Acylation Product in the SnCl4-promoted Reaction of 4,5-Dichlorocyclopent-4-en-1,3-dione with 1,3,5-Trimethoxybenzene[J]. Russian Journal of Organic Chemistry, 2023, 59 8: 1449-1452. DOI:10.1134/S1070428023080201.
[2] SEANGHAI HOR . Brnsted acid-catalyzed 1,4-addition of 1,3,5-trimethoxybenzene to maleimides and acrylates[J]. Tetrahedron Letters, 2021, 74: Article 153100. DOI:10.1016/j.tetlet.2021.153100.
[3] A. J. BELLAMY. Nitration of 1,3,5-Trimethoxybenzene[J]. Journal of Chemical Research-s, 2002, 109 3 1: 412-413. DOI:10.3184/030823402103172662.
1,3,5-Trimethoxybenzene Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhejiang Kinso Technology Co., LTD. | +86-571-56950601; +8619857958369 | sales@kinsopharma.com | China | 51 | 58 |
| Chengdu Yuanda Chemical Co., Ltd | 28-85356300 +8618980937689 | sales@ydachem.com | CHINA | 94 | 58 |
| Zhejiang Karry Pharmachem Co., Ltd. | +8613567161161 | info@karrypharma.com | China | 34 | 58 |
| Beijing Wisdom Chemicals Co., Ltd. | +8613701363759 | market@wisdomchem.com | China | 254 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5235 | 58 |
| Hebei Dangtong Import and export Co LTD | +86-86-4001020630 +8619831957301 | admin@hbdangtong.com | China | 1000 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 973 | 58 |
Related articles
- 1,3,5-Trimethoxybenzene: Role in Oxidation Reactions and its Biosynthesis Method
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- Sep 6，2024
View Lastest Price from 1,3,5-Trimethoxybenzene manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-17 | 1,3,5-Trimethoxybenzene
621-23-8
|
US $29.00 / mL | 99.95% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-03-20 | 1,3,5-Trimethoxybenzene
621-23-8
|
US $10.00 / kg | 1kg | 99% | 100 TON | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2026-02-25 | 1,3,5-Trimethoxybenzene
621-23-8
|
US $89.00-80.00 / kg | 1kg | 99% | 5000kg | Hebei Dangtong Import and export Co LTD |
-
- 1,3,5-Trimethoxybenzene
621-23-8
- US $29.00 / mL
- 99.95%
- TargetMol Chemicals Inc.
-
- 1,3,5-Trimethoxybenzene
621-23-8
- US $10.00 / kg
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 1,3,5-Trimethoxybenzene
621-23-8
- US $89.00-80.00 / kg
- 99%
- Hebei Dangtong Import and export Co LTD
