4H-PYRAN-4-ONE
- CAS No.
- 108-97-4
- Chemical Name:
- 4H-PYRAN-4-ONE
- Synonyms
- 4-Pyrone;Pyrocoman;PYRAN-4-ONE;GAMMA-PYRONE;4H-PYRAN-4-ONE;4H-Pyran, 4-oxo-;4H-Pyran-4-one>4H-PYRAN-4-ONE, 98+%;4H-Pyran-4-one;GAMMA-PYRONE, 4-PYRONE
- CBNumber:
- CB0376459
- Molecular Formula:
- C5H4O2
- Molecular Weight:
- 96.08
- MDL Number:
- MFCD00006576
- MOL File:
- 108-97-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 32-34 °C(lit.) |
|---|---|
| Boiling point | 210-215 °C(lit.) |
| Density | 1.20 |
| refractive index | 1.5238 |
| Flash point | 214 °F |
| storage temp. | 2-8°C |
| solubility | Slightly soluble in water, soluble in alcohol and oils. |
| form | clear liquid |
| color | Light yellow to Brown |
| Odor | Warm, slight ly pungent, hay-like herbaceous odor of moderate to poor tenacity. |
| BRN | 105293 |
| Stability | Polymerizes under exposure to air (oxygen) and alkali. Turns darker brown, and its odor fades. |
| InChI | 1S/C5H4O2/c6-5-1-3-7-4-2-5/h1-4H |
| InChIKey | CVQUWLDCFXOXEN-UHFFFAOYSA-N |
| SMILES | O=C1C=COC=C1 |
| LogP | -0.628 (est) |
| CAS DataBase Reference | 108-97-4 |
| FDA UNII | UJ7X07IM7Z |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 3-8-10 | |||||||||
| HS Code | 2932.99.9090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
4H-PYRAN-4-ONE price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 177229 | 4H-Pyran-4-one ≥98% | 108-97-4 | 1g | $136 | 2026-04-30 | Buy |
| Sigma-Aldrich | 177229 | 4H-Pyran-4-one ≥98% | 108-97-4 | 5g | $554 | 2026-04-30 | Buy |
| TCI Chemical | P1450 | 4H-Pyran-4-one >98.0%(GC) | 108-97-4 | 1g | $183 | 2026-04-30 | Buy |
| TCI Chemical | P1450 | 4H-Pyran-4-one >98.0%(GC) | 108-97-4 | 5g | $576 | 2026-04-30 | Buy |
| Activate Scientific | AS47510 | 4H-Pyran-4-one 95% | 108-97-4 | 1g | $86 | 2026-06-04 | Buy |
4H-PYRAN-4-ONE Chemical Properties,Uses,Production
Uses
4H-Pyran-4-one was used in the synthesis of probes grafted on the lipid headgroups.
Preparation
1) from Diethylacetone dioxalate by cyclization to Chelidonic acid (gamma-Pyrone-
2,6-dicarboxylic acid). The acid yields 4H-Pyran-4-one by decarboxylation.
2) by heating of I-Methoxypent-l -en-3-yn-5-
al diethylacetal with Methanol and water,
using Mercuric sulfate or Sulfuric acid
catalyst.
Definition
ChEBI: A pyranone that is 4H-pyran substituted by an oxo group at position 4.
Synthesis
159015-78-8
108-97-4
Example 1 (Synthesis of pyran-4-one): In a 10 mL glass reaction flask fitted with a stirring device and a dropping funnel, 1.0 g (4.8 mmol) of 1,1,5,5-tetramethoxypentan-3-one (CAS: 159015-78-8) was added. Under cooling in an ice bath, 1.2 mL (14.1 mmol) of 12 mol/L hydrochloric acid solution was slowly added dropwise to the reaction flask. After the dropwise addition, the reaction mixture was stirred at room temperature for 4 hours. Upon completion of the reaction, the reaction solution was analyzed by gas chromatography (internal standard method) to confirm the formation of 0.45 g (yield: 97%) of pyran-4-one.
Purification Methods
Purify -pyrone by vacuum distillation; the distillate crystallises and is hygroscopic. It is non-steam vola
References
[1] Patent: EP1700853, 2006, A1. Location in patent: Page/Page column 12
4H-PYRAN-4-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Changzhou Wanyao Biotechnology Co., Ltd. | 0519-89185693 15312551983 | 2410037592@qq.com | China | 278 | 55 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
View Lastest Price from 4H-PYRAN-4-ONE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 4H-PYRAN-4-ONE
108-97-4
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2025-04-04 | 4H-PYRAN-4-ONE
108-97-4
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2019-12-20 | 4H-PYRAN-4-ONE
108-97-4
|
$1.00 | 1KG | 99% | Career Henan Chemical Co |
-
- 4H-PYRAN-4-ONE
108-97-4
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 4H-PYRAN-4-ONE
108-97-4
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 4H-PYRAN-4-ONE
108-97-4
- $1.00
- 99%
- Career Henan Chemical Co
