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4-(2-THIENYL)BUTYRIC ACID

4-(2-THIENYL)BUTYRIC ACID structure

CAS No.: 4653-11-6

Chemical Name:: 4-(2-THIENYL)BUTYRIC ACID

Synonyms: 2-THIOPHENEBUTYRIC ACID;4-(2-thienyl)butyricaci;2-Thiophenebutanoic acid;4-(2-THIENYL)BUTYRIC ACID;Thiophene-2-butanoic acid;2-(2-THIENYL)BUTYRIC ACID;4-(2-Thienyl)butanoic acid;4-Thiophen-2-yl-butyric acid;4-(2-Thienyl)butyricacid,98+%;4-(2-Thienyl)butyric acid, GC 97%

CBNumber:: CB0401962

Molecular Formula:: C8H10O2S

Molecular Weight:: 170.23

MDL Number:: MFCD00005463

MOL File:: 4653-11-6.mol

Last updated:2026-01-13 11:13:14

Product description	Number	Pack Size	Price
4-(2-Thienyl)butyric acid 98%	T27804	10g	$192
4-(2-Thienyl)butyric acid 98%	T27804	2.5g	$74.3
4-(Thiophen-2-yl)butanoic Acid min. 95.0 %	T4178	1G	$45
4-(Thiophen-2-yl)butanoic Acid min. 95.0 %	T4178	5G	$135
2-ThiophenebutanoicAcid	T344130	25g	$265
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4-(2-THIENYL)BUTYRIC ACID Properties

Melting point	13.5-15 °C
Boiling point	122°C 0,3mm
Density	1.169 g/mL at 25 °C(lit.)
refractive index	n20/D 1.532(lit.)
Flash point	>230 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	4.71±0.10(Predicted)
form	Liquid
color	Clear slightly brown
Specific Gravity	1.1690
BRN	127982
InChI	1S/C8H10O2S/c9-8(10)5-1-3-7-4-2-6-11-7/h2,4,6H,1,3,5H2,(H,9,10)
InChIKey	VYTXLSQVYGNWLV-UHFFFAOYSA-N
SMILES	OC(=O)CCCc1cccs1
CAS DataBase Reference	4653-11-6(CAS DataBase Reference)
FDA UNII	VLB4C9G6WY
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-37/39

WGK Germany

HazardClass

IRRITANT

HS Code

29309099

Storage Class

10 - Combustible liquids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
3		0

4-(2-THIENYL)BUTYRIC ACID price More Price(31)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	T27804	4-(2-Thienyl)butyric acid 98%	4653-11-6	10g	$192	2025-07-31	Buy
Sigma-Aldrich	T27804	4-(2-Thienyl)butyric acid 98%	4653-11-6	2.5g	$74.3	2023-06-20	Buy
TCI Chemical	T4178	4-(Thiophen-2-yl)butanoic Acid min. 95.0 %	4653-11-6	1G	$45	2025-07-31	Buy
TCI Chemical	T4178	4-(Thiophen-2-yl)butanoic Acid min. 95.0 %	4653-11-6	5G	$135	2025-07-31	Buy
TRC	T344130	2-ThiophenebutanoicAcid	4653-11-6	25g	$265	2021-12-16	Buy

Product number	Packaging	Price	Buy
T27804	10g	$192	Buy
T27804	2.5g	$74.3	Buy
T4178	1G	$45	Buy
T4178	5G	$135	Buy
T344130	25g	$265	Buy

4-(2-THIENYL)BUTYRIC ACID Chemical Properties,Uses,Production

Chemical Properties

CLEAR SLIGHTLY BROWNISH LIQUID

Uses

2-Thiophenebutanoic Acid is used to prepare cell-penetrating peptide α-keto-amide calpain inhibitors as potential treatment for muscular dystrophy. it is also used to prepare isochroman carboxylic acid derivatives as potential anti-diabetic agents.

Definition

ChEBI: A monocarboxylic acid that is butyric acid bearing a 2-thienyl group at position 4.

Synthesis

4653-08-1

4653-11-6

The general procedure for the synthesis of 4-(2-thienyl)butyric acid from 3-(2-thiophenecarbonyl)propionic acid was as follows: 4-oxo-4-(thiophen-2-yl)butyric acid (2.3 g, 12.48 mmol) was dissolved in ethylene glycol (30 mL), and hydrazine hydrate (99%, 2.2 mL, 45.9 mmol) and potassium hydroxide pellets (2.37 g, 42.4 mmol). The reaction mixture was heated to 180 °C and maintained for 10 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was diluted with water. The aqueous layer was washed with ether, acidified with 6N hydrochloric acid and extracted with ether. The organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by column chromatography (silica gel 60-120 mesh, eluent 2% dichloromethane solution in methanol) to give 4-(thiophen-2-yl)butanoic acid (1.8 g, 85% yield). The product was confirmed by 1H NMR (300 MHz, DMSO-d6) and mass spectrometry (ESI): 1H NMR δ 12.06 (s, 1H), 7.31-7.29 (m, 1H), 6.94-6.91 (m, 1H), 6.84-6.82 (m, 1H), 2.82-2.77 (t, J=7.7 Hz, 2H), 2.27- 2.22 (t, J=7.3Hz, 2H), 1.86-1.76 (m, 2H); MS (ESI) m/z: [M+H]+ Calculated value 170.04, measured value 170.8.

References

[1] European Journal of Medicinal Chemistry, 1998, vol. 33, # 11, p. 867 - 877
[2] Patent: WO2011/88187, 2011, A1. Location in patent: Page/Page column 60-61
[3] Patent: WO2010/76188, 2010, A1. Location in patent: Page/Page column 17-19
[4] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980, p. 1185 - 1193
[5] Archiv der Pharmazie, 1988, vol. 321, # 10, p. 735 - 738

4-(2-THIENYL)BUTYRIC ACID Preparation Products And Raw materials

Raw materials

Diethylene glycol Hydrazinium hydroxide solution Potassium hydroxide Calcium chloride Succinic anhydride

Thiophene Aluminum chloride Diethyl ether Hydrochloric acid Nitrobenzene

Sodium carbonate

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Preparation Products

4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE

4-(2-THIENYL)BUTYRIC ACID Suppliers

Global( 127)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Dideu Medichem Co. Ltd	+86-29-81139210 +86-18192627656	1059@dideu.com	China	3589	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30229	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58
Finetech Industry Limited	+86-27-8746-5837 +8619945049750	info@finetechnology-ind.com	China	9629	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52846	58
Alfa Chemistry	+1-5166625404;	Info@alfa-chemistry.com	United States	20405	58

Supplier	Advantage
Shaanxi Dideu Medichem Co. Ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Hebei Yanxi Chemical Co., Ltd.	58
Career Henan Chemica Co	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
ANHUI WITOP BIOTECH CO., LTD	58
Finetech Industry Limited	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Alfa Chemistry	58

View Lastest Price from 4-(2-THIENYL)BUTYRIC ACID manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-12-12	4-(2-Thienyl)butyric acid 4653-11-6	US $1.00-1.50 / KG	1KG	99%	100000KG	Shaanxi Dideu Medichem Co. Ltd
	2021-08-12	4-(2-THIENYL)BUTYRIC ACID 4653-11-6	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

4-(2-Thienyl)butyric acid
4653-11-6
US $1.00-1.50 / KG
99%
Shaanxi Dideu Medichem Co. Ltd

4-(2-THIENYL)BUTYRIC ACID
4653-11-6
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

4-(2-THIENYL)BUTYRIC ACID Spectrum

4-(2-THIENYL)BUTYRIC ACID(4653-11-6)MS 4-(2-THIENYL)BUTYRIC ACID(4653-11-6)¹HNMR 4-(2-THIENYL)BUTYRIC ACID(4653-11-6)¹³CNMR 4-(2-THIENYL)BUTYRIC ACID(4653-11-6)IR1

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4-(2-THIENYL)BUTYRIC ACID 2-Thiophenebutanoic acid 4-(2-Thienyl)butanoic acid gamma-(alpha-Thienyl)butyric acid 2-THIOPHENEBUTYRIC ACID 4-(2-Thienyl)butyricacid,98+% 2-(2-THIENYL)BUTYRIC ACID 4-(2-Thienyl)butyric acid, GC 97% Thiophene-2-butanoic acid 4-Thiophen-2-yl-butyric acid 4-(2-Thienyl)butyric acid, 98% 1GR 4-(2-thienyl)butyricaci 4653-11-6 653-11-6 Heterocyclic Building Blocks Thiophenes Building Blocks Heterocycles