tert-Butylhydroquinone
- CAS No.
- 1948-33-0
- Chemical Name:
- tert-Butylhydroquinone
- Synonyms
- TBHQ;TERTIARY BUTYL HYDROQUINONE;T-BUTYLHYDROQUINONE;2-tert-butylhydroquinone;MTBHQ;Butylhydroquinone;MONO-TERT-BUTYLHYDROQUINONE;Sustane;Antioxidant TBHQ;TERT-BUTYLHYDROCHINONE
- CBNumber:
- CB0415105
- Molecular Formula:
- C10H14O2
- Molecular Weight:
- 166.22
- MDL Number:
- MFCD00002344
- MOL File:
- 1948-33-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 127-129 °C(lit.) |
|---|---|
| Boiling point | 295 °C |
| Density | 295 |
| vapor pressure | 0.004Pa at 25℃ |
| refractive index | 1.4859 (estimate) |
| Flash point | 171 °C |
| storage temp. | Store below +30°C. |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 10.80±0.18(Predicted) |
| form | Crystalline Powder |
| color | White to light tan, may contain black specs |
| Water Solubility | Slightly soluble in water(10g/L). |
| BRN | 637923 |
| Stability | Stable. Incompatible with strong bases, strong oxidizing agents. |
| Cosmetics Ingredients Functions |
FRAGRANCE PERFUMING ANTIOXIDANT |
| InChI | 1S/C10H14O2/c1-10(2,3)8-6-7(11)4-5-9(8)12/h4-6,11-12H,1-3H3 |
| InChIKey | BGNXCDMCOKJUMV-UHFFFAOYSA-N |
| SMILES | CC(C)(C)c1cc(O)ccc1O |
| LogP | 1.521 at 25℃ |
| Toxicology and Carcinogenesis | Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CASRN 1948-33-0) in F344 Rats and B6C3F1 Mice (Feed Studies) |
| Substances Added to Food (formerly EAFUS) | TERT-BUTYLHYDROQUINONE |
| FDA 21 CFR | 177.2420 |
| CAS DataBase Reference | 1948-33-0(CAS DataBase Reference) |
| FDA UNII | C12674942B |
| NIST Chemistry Reference | 1,4-Benzenediol, 2-(1,1-dimethylethyl)-(1948-33-0) |
| EPA Substance Registry System | tert-Butylhydroquinone (1948-33-0) |
| UNSPSC Code | 12352104 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312-H315-H317-H319-H410 | |||||||||
| Precautionary statements | P273-P280-P301+P312+P330-P302+P352+P312-P305+P351+P338 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36-28A | |||||||||
| RIDADR | UN3077 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | MX4375000 | |||||||||
| Autoignition Temperature | 855 °F | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 9 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29072900 | |||||||||
| Storage Class | 13 - Non Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Oral Aquatic Acute 1 Aquatic Chronic 1 Eye Irrit. 2 Skin Irrit. 2 Skin Sens. 1 |
|||||||||
| Hazardous Substances Data | 1948-33-0(Hazardous Substances Data) | |||||||||
| Toxicity | guinea pig,LD50,oral,790mg/kg (790mg/kg),WHO Food Additives Series. Vol. 8, Pg. 26, 1975. | |||||||||
| REACH Registrations | Active | |||||||||
| Limited Quantities | 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
tert-Butylhydroquinone price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.41424 | tert-Butylhydroquinone for synthesis | 1948-33-0 | 100g | $51 | 2026-04-30 | Buy |
| Sigma-Aldrich | PHR3512 | tert-Butylhydroquinone certified reference material, pharmaceutical secondary standard | 1948-33-0 | 500 mg | $211 | 2026-04-30 | Buy |
| Sigma-Aldrich | 112941 | tert-Butylhydroquinone 97% | 1948-33-0 | 5g | $41.7 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.41424 | tert-Butylhydroquinone for synthesis | 1948-33-0 | 500g | $164 | 2026-04-30 | Buy |
| Sigma-Aldrich | 07293 | tert-Butylhydroquinone analytical standard | 1948-33-0 | 100mg | $93.2 | 2026-04-30 | Buy |
tert-Butylhydroquinone Chemical Properties, Uses, Production
Chemical Properties
White, crystalline solid having a characteristic odour.
tert-Butylhydroquinone (TBHQ) is an antioxidant used to preserve oils, fats and food items. It is found in vegetable oils and animal fats, varnishes, lacquers, resins, oils field additives, and perfumes.In low concentrations it shows cytoprotective qualities while at higher concentrations it exhibits cytotoxic behavior.
TBHQ was used to study the inactivation of barotolerant strains of Listeria monocytogenes and Escherichia coli.Environment friendly electrode materials for supercapacitors were attained by decorating the surface of graphene nanosheets with TBHQ.
Uses
tert-Butylhydroquinone (TBHQ) is an antioxidant that exhibits an excellent stabilizing effect in unsaturated fats and oils. It has good solubility in fats and oils, with a maximum usage level of 0.02% based on the weight of the fat or oil or the fat content of the food product. It shows no discoloration in the presence of iron and produces no discernible flavor or odor. It can be combined with BHA and BHT. It is used in edible fats and vegetable oils to retard rancidity. It is used in potato chips and dry cereal. It is also termed butylhydroquinone and mono-tertiary-butylhydroquinone.
Uses
antioxidant in cosmetic products like lipsticks.
Uses
TBHQ was used to study the inactivation of barotolerant strains of Listeria monocytogenes and Escherichia coli. Environment friendly electrode materials for supercapacitors were attained by decorating the surface of graphene nanosheets with TBHQ. TBHQ is frequently used as a food preservative. Inhibition of oxidative rancidity in frozen cooked fish flakes by tert-butylhydroquinone. Nuclear factor E2-related factor 2-dependent antioxidant response element activation is by tert-butylhydroquinoneoccurring preferentially in Astrocytes conditions.
Definition
ChEBI: A member of the class of hydroquinones in which one of the ring hydrogens of hydroquinone is replaced by a tert-butyl group.
General Description
White to light tan crystalline powder or a fine beige powder. Very slight aromatic odor.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Phenols, such as tert-Butylhydroquinone, do not behave as organic alcohols, as one might guess from the presence of a hydroxyl (-OH) group in their structure. Instead, they react as weak organic acids. Phenols and cresols are much weaker as acids than common carboxylic acids (phenol has Ka = 1.3 x 10^[-10]). These materials are incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction between phenols and bases. Such heating may initiate polymerization of the organic compound. Phenols are sulfonated very readily (for example, by concentrated sulfuric acid at room temperature). The reactions generate heat. Phenols are also nitrated very rapidly, even by dilute nitric acid. Nitrated phenols often explode when heated. Many of them form metal salts that tend toward detonation by rather mild shock. tert-Butylhydroquinone is incompatible with oxidizers.
Fire Hazard
tert-Butylhydroquinone is combustible.
Flammability and Explosibility
Non flammable
Contact allergens
This antioxidant has seldom been reported as a sensitizer, mainly in cosmetics (lipsticks, lip-gloss, hair dyes) or in cutting oils. Simultaneous/cross-reactions have been described to butylhydroxyanisole (BHA) and less frequently to butylhydroxytoluene (BHT), but not to hydroquinone
Synthesis
123-31-9
75-65-0
1948-33-0
1) add 3 wt. parts of phosphoric acid and 0.1 wt. parts of water into a stirring cylinder, followed by adding 6 wt. parts of hydroquinone, and start the stirrer for mixing; 2) transfer the mixed solution into a reactor, and add tertiary butanol slowly after heating up to 59°C; 3) continue to heat up to 81°C, and maintain the reaction at this temperature for 2 hrs; 4) after completion of the reaction, centrifuge the product, and then wash and dehydrate it to obtain TBHQ crude oil; 5) mix 1 wt. part of acid with 95 wt. part of water, heat to 81°C, then add 6.5 wt. part of TBHQ crude oil, and heat to 95°C with stirring; 6) carry out a first centrifugation of the solution of step 5) to isolate DTBHQ insoluble in water, and then subsequently cool down the solution to below 45°C, carry out a second centrifugation, and the TBHQ crystals obtained are washed, dehydration and then dried; during the drying process, the wet TBHQ crystals were uniformly spread on a vibrating screen, sieved and then flatly spread on a drying disk with the thickness controlled at 5 cm, and dried for 8 hours, and ultimately obtained a TBHQ boutique product with a TBHQ content of 99.9% and a DTBHQ content of 0.1%.
Purification Methods
Recrystallise the hydroquinone from H2O or MeOH and dry it in a vacuum at 70o. Store it in a dark container. [Stroh et al. Angew Chem 69 699 1957, Beilstein 6 IV 6013.]
References
[1] Patent: CN103864580, 2016, B. Location in patent: Paragraph 0095-0104
[2] Patent: US2511193, 1947,
[3] Patent: US2722556, 1952,
[4] Patent: CN105541560, 2016, A. Location in patent: Paragraph 0011
[5] Patent: WO2018/214039, 2018, A1. Location in patent: Page/Page column 12-15
tert-Butylhydroquinone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shandong Pepsi Food Technology Co. , Ltd. | 0538-6386018 17753887766 | sdbaishiyi@163.com | China | 3 | 58 |
| Tianjin Zhongxin Chemtech Co., Ltd. | 022-66880623 | sales@tjzxchem.com | China | 612 | 60 |
| Nanjing Lanbai Chemical Co., Ltd. | 025-85499326 15366059326;13813836665 | 1911566570@qq.com | China | 110 | 57 |
| Wuxi QianFeng Chemical Technology Co., Ltd. | 0510-82860650 | qfhg@qianfengchem.com | China | 25 | 55 |
| Cheng Du Micxy Chemical Co.,Ltd | 028-85632863 18108198598 | 3829395549@qq.com | China | 10469 | 58 |
| Shandong Xinxiong Biotechnology Co., Ltd | 15666663101 | 3786416211@qq.com | China | 2440 | 58 |
| Chengdu Yuanda chemical co.,ltd | 028-85356300 18980937689 | chenquanxing@126.com | China | 161 | 55 |
| 0 | 18769832557 18769832557 | 3948893484@QQ.com | China | 2976 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd. | 13131120796 13131120796 | kelly@chuanghaibio.com | China | 985 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
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Related Questions
Ask a questionView Latest Price from tert-Butylhydroquinone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-10-08 | tert-Butylhydroquinone
1948-33-0
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-10-08 | tert-Butylhydroquinone
1948-33-0
|
1kg | 98% | 100 T/Month | Hebei Qujie Technology Co., Ltd. | ||
 |
2026-10-02 | tert-Butylhydroquinone
1948-33-0
|
$700.00-900.00 | 1ton | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD |
-
- tert-Butylhydroquinone
1948-33-0
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- tert-Butylhydroquinone
1948-33-0
- 98%
- Hebei Qujie Technology Co., Ltd.
-
- tert-Butylhydroquinone
1948-33-0
- $700.00-900.00
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
