Sancycline
- CAS No.
- 808-26-4
- Chemical Name:
- Sancycline
- Synonyms
- Sancycline Hydrochloride;(4S,4aS,5aR,12aS)-4-(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide;CS-676;GS 2147;Bonomycin;NSC-51812;Norcycline;SANCYCLINE;Sancyclinum;808-26-4 Sancycline
- CBNumber:
- CB0420370
- Molecular Formula:
- C21H22N2O7
- Molecular Weight:
- 414.41
- MDL Number:
- MFCD00864992
- MOL File:
- 808-26-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Sancycline ≥95% (H-NMR), powder | SBR00097 | 100 mg | $362 |
| Sancycline ≥95% (H-NMR), powder | SBR00097 | 1 unit | $340 |
| (4S,4AS,5AR,12AS)-4-(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDRO-2-NAPHTHACENECARBOXAMIDE AldrichCPR | PH000287 | 1MG | $172 |
| Sancycline ≥98% | 23100 | 5mg | $32 |
| Sancycline ≥98% | 23100 | 25mg | $122 |
| More product size | |||
| Melting point | 224-2280C (dec) |
|---|---|
| Boiling point | 750.9±60.0 °C(Predicted) |
| Density | 1.61±0.1 g/cm3(Predicted) |
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | Aqueous Acid (Slightly), Chloroform (Slightly), Methanol (Slightly) |
| pka | 4.50±1.00(Predicted) |
| form | Solid |
| color | Beige to Dark Beige |
| Stability | Hygroscopic |
| InChIKey | XDVCLKFLRAWGIT-ADOAZJKMSA-N |
| SMILES | C1(=O)[C@]2(O)[C@@]([H])(C[C@@]3([H])C(=C2O)C(=O)C2=C(C=CC=C2O)C3)[C@H](N(C)C)C(O)=C1C(N)=O |
| CAS DataBase Reference | 808-26-4 |
| FDA UNII | ODN00F2SJG |
| UNSPSC Code | 51101500 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H362 | |||||||||
| Precautionary statements | P201-P260-P263-P264-P270-P308+P313 | |||||||||
| NFPA 704 |
|
Sancycline price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SBR00097 | Sancycline ≥95% (H-NMR), powder | 808-26-4 | 100 mg | $362 | 2026-03-19 | Buy |
| Sigma-Aldrich | SBR00097 | Sancycline ≥95% (H-NMR), powder | 808-26-4 | 1 unit | $340 | 2025-07-31 | Buy |
| Sigma-Aldrich | PH000287 | (4S,4AS,5AR,12AS)-4-(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDRO-2-NAPHTHACENECARBOXAMIDE AldrichCPR | 808-26-4 | 1MG | $172 | 2023-06-20 | Buy |
| Cayman Chemical | 23100 | Sancycline ≥98% | 808-26-4 | 5mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 23100 | Sancycline ≥98% | 808-26-4 | 25mg | $122 | 2024-03-01 | Buy |
Sancycline Chemical Properties,Uses,Production
Description
Sancycline is a semisynthetic tetracycline antibiotic that is more active than tetracycline against 339 strains of anaerobic bacteria (average MIC90s = 1 and 32 μg/ml, respectively). Sancycline is active against tetracycline-resistant E. coli, S. aureus, and E. faecalis strains with MICs ranging from 0.06 to 1 μg/ml. In vivo, sancycline is active against S. aureus in mice with ED50 values of 0.46 and 0.6 mg/kg for intravenous and subcutaneous administration, respectively.
Chemical Properties
Yellow Solid
Uses
A semi-synthetic antibiotic related to tetracycline
Uses
Sancycline is a rare semi-synthetic tetracycline prepared by hydrogenolysis of the chloro and benzylic hydroxy moieties of declomycin, first reported in 1962. As the simplest of the early tetracyclines, sancycline was the first to be totally synthesised by Conover and co-workers. Like other tetracyclines, sancycline acts by reversibly binding to the 30S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome A site.
Uses
Sancycline is a tetracycline bacteriostatic antibiotic which also binds to the Tet repressor protein (TetR).
Definition
ChEBI: Sancycline is a member of tetracyclines.
brand name
Bonomycin (Pfizer).
References
[1] J. R. D. MCCORMICK. The 6-Deoxytetracyclines.1 Further Studies on the Relationship between Structure and Antibacterial Activity in the Tetracycline Series[J]. Journal of the American Chemical Society, 1960, 82 13: 3381-3386. DOI: 10.1021/ja01498a037
[2] H M WEXLER S M F E Molitoris. In vitro activities of two new glycylcyclines, N,N-dimethylglycylamido derivatives of minocycline and 6-demethyl-6-deoxytetracycline, against 339 strains of anaerobic bacteria.[J]. Antimicrobial Agents and Chemotherapy, 1994, 38 10: 2513-2515. DOI: 10.1128/aac.38.10.2513
[3] R T TESTA. In vitro and in vivo antibacterial activities of the glycylcyclines, a new class of semisynthetic tetracyclines.[J]. Antimicrobial Agents and Chemotherapy, 1993, 37 11: 2270-2277. DOI: 10.1128/aac.37.11.2270
Sancycline Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Allsino Pharmaceutical Co.,Ltd | +86-571-88180350 +86-13588846430 | sales@allsino.com | China | 101 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21592 | 55 |
| Guangzhou PI PI BIOTECH INC | +86-86-020-81716320 +8613602409664 | Sales@pipitech.com | China | 973 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29821 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2994 | 58 |
| TianYuan Pharmaceutical CO.,LTD | +86-755-23284190 13684996853 | sales@tianpharm.com | CHINA | 304 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| HubeiwidelychemicaltechnologyCo.,Ltd | 18627774460 | faith@widelychemical.com | CHINA | 742 | 58 |
View Lastest Price from Sancycline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-22 | Sancycline
808-26-4
|
US $38.00-128.00 / mg | 98.41% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-03-12 | Minocycline EP Impurity B
808-26-4
|
US $0.00-0.00 / mg | 10mg | 0.98 | 5g | ShenZhen H&D Pharmaceutical Technology Co., LTD | |
 |
2025-12-19 | Minocycline EP Impurity B
808-26-4
|
US $0.00-0.00 / mg | 10mg | 90%+ | 10g | Guangzhou PI PI BIOTECH INC |
-
- Sancycline
808-26-4
- US $38.00-128.00 / mg
- 98.41%
- TargetMol Chemicals Inc.
-
- Minocycline EP Impurity B
808-26-4
- US $0.00-0.00 / mg
- 0.98
- ShenZhen H&D Pharmaceutical Technology Co., LTD
-
- Minocycline EP Impurity B
808-26-4
- US $0.00-0.00 / mg
- 90%+
- Guangzhou PI PI BIOTECH INC
