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Sancycline

Sancycline Structure
Sancycline structure
CAS No.
808-26-4
Chemical Name:
Sancycline
Synonyms
6-Demethyl-6-deoxytetracycline;Sancycline Hydrochloride;(4S,4aS,5aR,12aS)-4-(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide;(4S,4aS,5aR,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1-11-dioxo-2-naphthacenecarboxamide;CS-676;GS 2147;NSC-51812;Bonomycin;SANCYCLINE;Norcycline
CBNumber:
CB0420370
Molecular Formula:
C21H22N2O7
Molecular Weight:
414.41
MDL Number:
MFCD00864992
MOL File:
808-26-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-05 16:06:58
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Sancycline Properties

Melting point 224-2280C (dec)
Boiling point 750.9±60.0 °C(Predicted)
Density 1.61±0.1 g/cm3(Predicted)
storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility Aqueous Acid (Slightly), Chloroform (Slightly), Methanol (Slightly)
form Solid
pka 4.50±1.00(Predicted)
color Beige to Dark Beige
Stability Hygroscopic
InChIKey XDVCLKFLRAWGIT-ADOAZJKMSA-N
SMILES C1(=O)[C@]2(O)[C@@]([H])(C[C@@]3([H])C(=C2O)C(=O)C2=C(C=CC=C2O)C3)[C@H](N(C)C)C(O)=C1C(N)=O
CAS DataBase Reference 808-26-4
FDA UNII ODN00F2SJG
UNSPSC Code 51101500

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H362
Precautionary statements  P201-P260-P263-P264-P270-P308+P313
REACH Registrations Active
NFPA 704
0
2 0

Sancycline price More Price(50)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SBR00097 Sancycline ≥95% (H-NMR), powder 808-26-4 100 mg $362 2026-04-30 Buy
Sigma-Aldrich SBR00097 Sancycline ≥95% (H-NMR), powder 808-26-4 1 unit $340 2025-07-31 Buy
Sigma-Aldrich PH000287 (4S,4AS,5AR,12AS)-4-(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDRO-2-NAPHTHACENECARBOXAMIDE AldrichCPR 808-26-4 1MG $172 2023-06-20 Buy
Cayman Chemical 23100 Sancycline ≥98% 808-26-4 5mg $36 2026-04-30 Buy
Cayman Chemical 23100 Sancycline ≥98% 808-26-4 25mg $135 2026-04-30 Buy
Product number Packaging Price Buy
SBR00097 100 mg $362 Buy
SBR00097 1 unit $340 Buy
PH000287 1MG $172 Buy
23100 5mg $36 Buy
23100 25mg $135 Buy

Sancycline Chemical Properties, Uses, Production

Description

Sancycline is a semisynthetic tetracycline antibiotic that is more active than tetracycline against 339 strains of anaerobic bacteria (average MIC90s = 1 and 32 μg/ml, respectively). Sancycline is active against tetracycline-resistant E. coli, S. aureus, and E. faecalis strains with MICs ranging from 0.06 to 1 μg/ml. In vivo, sancycline is active against S. aureus in mice with ED50 values of 0.46 and 0.6 mg/kg for intravenous and subcutaneous administration, respectively.

Chemical Properties

Yellow Solid

Uses

A semi-synthetic antibiotic related to tetracycline

Uses

Sancycline is a rare semi-synthetic tetracycline prepared by hydrogenolysis of the chloro and benzylic hydroxy moieties of declomycin, first reported in 1962. As the simplest of the early tetracyclines, sancycline was the first to be totally synthesised by Conover and co-workers. Like other tetracyclines, sancycline acts by reversibly binding to the 30S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome A site.

Uses

Sancycline is a tetracycline bacteriostatic antibiotic which also binds to the Tet repressor protein (TetR).

Definition

ChEBI: Sancycline is a member of tetracyclines.

brand name

Bonomycin (Pfizer).

References

[1] J. R. D. MCCORMICK. The 6-Deoxytetracyclines.1 Further Studies on the Relationship between Structure and Antibacterial Activity in the Tetracycline Series[J]. Journal of the American Chemical Society, 1960, 82 13: 3381-3386. DOI: 10.1021/ja01498a037
[2] H M WEXLER  S M F  E Molitoris. In vitro activities of two new glycylcyclines, N,N-dimethylglycylamido derivatives of minocycline and 6-demethyl-6-deoxytetracycline, against 339 strains of anaerobic bacteria.[J]. Antimicrobial Agents and Chemotherapy, 1994, 38 10: 2513-2515. DOI: 10.1128/aac.38.10.2513
[3] R T TESTA. In vitro and in vivo antibacterial activities of the glycylcyclines, a new class of semisynthetic tetracyclines.[J]. Antimicrobial Agents and Chemotherapy, 1993, 37 11: 2270-2277. DOI: 10.1128/aac.37.11.2270

Sancycline Preparation Products And Raw materials

Raw materials

Preparation Products

Sancycline Suppliers

Global Suppliers ( 227)
Supplier Tel Email Country ProdList Advantage
Jiangxi ravel Biotechnology Co.,Ltd 18502728206 hj@ruiweier.cn China 2436 58
Shanghai Zhen Li Biological Technology Co., Ltd 021-16621358918; 18516310516;16621358918;13045646768 zhenlipharma888@163.com China 19060 58
Cdreamlab (Hubei) Technology Co., LTD 18062399888; 18062399888 service@cdreamlab.com China 129 58
Nanjing Vcare PharmaTech Co., Ltd 025-58741518 13327700685 sales@vcarepharmatech.com China 483 58
Taizhou Huaxi Technology Co. LTD 0576-89164227 13105618688 18323010@qq.com China 39 58
Zhuhai Yourun Co., Ltd. 0756-6811852 15876689832 zhyrpharm_sales03@126.com China 290 55
Hunan ravel Biotechnology Co.,Ltd 18086085632 435918333@qq.com China 1926 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2915 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Supplier Advantage
Jiangxi ravel Biotechnology Co.,Ltd 58
Shanghai Zhen Li Biological Technology Co., Ltd 58
Cdreamlab (Hubei) Technology Co., LTD 58
Nanjing Vcare PharmaTech Co., Ltd 58
Taizhou Huaxi Technology Co. LTD 58
Zhuhai Yourun Co., Ltd. 55
Hunan ravel Biotechnology Co.,Ltd 58
Shanghai Boyle Chemical Co., Ltd. 55
J & K SCIENTIFIC LTD. 76
Chembest Research Laboratories Limited 61

View Latest Price from Sancycline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Sancycline pictures 2026-07-04 Sancycline
808-26-4
 $38.00-128.00 99.37% 10g TargetMol Chemicals Inc.
Sancycline pictures 2026-06-30 Sancycline
808-26-4
 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd
Minocycline EP Impurity B pictures 2026-03-12 Minocycline EP Impurity B
808-26-4
 10mg 0.98 5g ShenZhen H&D Pharmaceutical Technology Co., LTD
  • Sancycline pictures
  • Sancycline
    808-26-4
  • $38.00-128.00
  • 99.37%
  • TargetMol Chemicals Inc.
  • Sancycline pictures
  • Sancycline
    808-26-4
  • $0.00
  • 99%
  • Shaanxi Dideu New Materials Co. Ltd

Sancycline Spectrum

Sancycline(808-26-4)1HNMR

808-26-4 (Sancycline) Related Search:

Oxytetracycline hydrochloride Minocycline Metacycline hydrochloride Minocycline hydrochloride 3-Dimethylaminopropylamine
Cyclosporin A Salicylanilide Salinomycin Nortropinone hydrochloride Deslanoside
Tetracycline hydrochloride Doxycycline 9-Amino minocycline hydrochloride pipacycline meclocycline
Chlortetracycline Doxycycline hydrochloride Methacycline hydrochloride

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SANCYCLINE Bonomycin GS 2147 Norcycline (4S,4aS,5aR,12aS)-4-(Dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-2-naphthacenecarboxamide NSC-51812 Minocycline IMpurity B 2-NaphthacenecarboxaMide,4-(diMethylaMino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-,(4S,4aS,5aR,12aS)- (4S,4aS,5aR,12aS)-4-(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide 6-DeMethyl-6-deoxytetracycline, BonoMycin, Norcycline BONOMYCIN; NORCYCLINE;6-DEMETHYL-6-DEOXYTETRACYCLINE Minocycline EP Impurity B/Sancycline/(4S,5aS,8Z,10E,14aS)-4-(dimethylamino)-3,11,14,14a-tetrahydroxy-1,13-dioxo-1,4,4a,5,5a,6,7,12,13,14a-decahydrocyclodeca[b]naphthalene-2-carboxamide CS-676 Sancycline in stock Factory Sancycline (Bonomycin Sancyclinum Minocycline EP Impurity B (Sancycline) SancyclineQ: What is Sancycline Q: What is the CAS Number of Sancycline Q: What is the storage condition of Sancycline Q: What are the applications of Sancycline 808-26-4 Sancycline (4S,4aS,5aR,12aR)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide Sancycline, 10 mM in DMSO Minocycline E Impurity B Sarecycline Impurity 25 (4S,4aS,5aR,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1-11-dioxo-2-naphthacenecarboxamide 6-Demethyl-6-deoxytetracycline Sancycline Hydrochloride 808-26-4 208538-73-6 C21H22N2O7 C21H23ClN2O7 Intermediates & Fine Chemicals Pharmaceuticals